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Re-Shaping the Pancreatic Cancer Tumor Microenvironment: A New Role for the Metastasis Suppressor NDRG1

SIMPLE SUMMARY: Pancreatic cancer remains the leading cause of cancer death globally. With no reliable early detection strategy and limited treatment options, up to 90% of patients will lose their lives to this disease. In this review, we bring together recent advances in understanding the pancreati...

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Autores principales: Chang, Jiawei, Lo, Zoe H. Y., Alenizi, Shafi, Kovacevic, Zaklina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10216318/
https://www.ncbi.nlm.nih.gov/pubmed/37345116
http://dx.doi.org/10.3390/cancers15102779
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author Chang, Jiawei
Lo, Zoe H. Y.
Alenizi, Shafi
Kovacevic, Zaklina
author_facet Chang, Jiawei
Lo, Zoe H. Y.
Alenizi, Shafi
Kovacevic, Zaklina
author_sort Chang, Jiawei
collection PubMed
description SIMPLE SUMMARY: Pancreatic cancer remains the leading cause of cancer death globally. With no reliable early detection strategy and limited treatment options, up to 90% of patients will lose their lives to this disease. In this review, we bring together recent advances in understanding the pancreatic cancer tumor microenvironment, highlighting a protein that was recently discovered to potently attenuate pancreatic cancer progression by influencing its cross-talk with the microenvironment. ABSTRACT: Pancreatic cancer (PaC) is a highly aggressive disease, with poor response to current treatments and 5-year survival rates of 10–15%. PaC progression is facilitated by its interaction with the complex and multifaceted tumor microenvironment (TME). In the TME, cancer cells and surrounding stromal cells constantly communicate with each other via the secretion and uptake of factors including cytokines, chemokines, growth factors, metabolites, and extracellular vesicles (EVs), reshaping the landscape of PaC. Recent studies demonstrated that the metastasis suppressor N-myc downstream regulated 1 (NDRG1) not only inhibits oncogenic signaling pathways in PaC cells but also alters the communication between PaC cells and the surrounding stroma. In fact, NDRG1 was found to influence the secretome of PaC cells, alter cancer cell metabolism, and interfere with intracellular trafficking and intercellular communication between PaC cells and surrounding fibroblasts. This review will present recent advancements in understanding the role of NDRG1 in PaC progression, with a focus on how this molecule influences PaC-stroma communication and its potential for re-shaping the PaC TME.
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spelling pubmed-102163182023-05-27 Re-Shaping the Pancreatic Cancer Tumor Microenvironment: A New Role for the Metastasis Suppressor NDRG1 Chang, Jiawei Lo, Zoe H. Y. Alenizi, Shafi Kovacevic, Zaklina Cancers (Basel) Review SIMPLE SUMMARY: Pancreatic cancer remains the leading cause of cancer death globally. With no reliable early detection strategy and limited treatment options, up to 90% of patients will lose their lives to this disease. In this review, we bring together recent advances in understanding the pancreatic cancer tumor microenvironment, highlighting a protein that was recently discovered to potently attenuate pancreatic cancer progression by influencing its cross-talk with the microenvironment. ABSTRACT: Pancreatic cancer (PaC) is a highly aggressive disease, with poor response to current treatments and 5-year survival rates of 10–15%. PaC progression is facilitated by its interaction with the complex and multifaceted tumor microenvironment (TME). In the TME, cancer cells and surrounding stromal cells constantly communicate with each other via the secretion and uptake of factors including cytokines, chemokines, growth factors, metabolites, and extracellular vesicles (EVs), reshaping the landscape of PaC. Recent studies demonstrated that the metastasis suppressor N-myc downstream regulated 1 (NDRG1) not only inhibits oncogenic signaling pathways in PaC cells but also alters the communication between PaC cells and the surrounding stroma. In fact, NDRG1 was found to influence the secretome of PaC cells, alter cancer cell metabolism, and interfere with intracellular trafficking and intercellular communication between PaC cells and surrounding fibroblasts. This review will present recent advancements in understanding the role of NDRG1 in PaC progression, with a focus on how this molecule influences PaC-stroma communication and its potential for re-shaping the PaC TME. MDPI 2023-05-16 /pmc/articles/PMC10216318/ /pubmed/37345116 http://dx.doi.org/10.3390/cancers15102779 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Chang, Jiawei
Lo, Zoe H. Y.
Alenizi, Shafi
Kovacevic, Zaklina
Re-Shaping the Pancreatic Cancer Tumor Microenvironment: A New Role for the Metastasis Suppressor NDRG1
title Re-Shaping the Pancreatic Cancer Tumor Microenvironment: A New Role for the Metastasis Suppressor NDRG1
title_full Re-Shaping the Pancreatic Cancer Tumor Microenvironment: A New Role for the Metastasis Suppressor NDRG1
title_fullStr Re-Shaping the Pancreatic Cancer Tumor Microenvironment: A New Role for the Metastasis Suppressor NDRG1
title_full_unstemmed Re-Shaping the Pancreatic Cancer Tumor Microenvironment: A New Role for the Metastasis Suppressor NDRG1
title_short Re-Shaping the Pancreatic Cancer Tumor Microenvironment: A New Role for the Metastasis Suppressor NDRG1
title_sort re-shaping the pancreatic cancer tumor microenvironment: a new role for the metastasis suppressor ndrg1
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10216318/
https://www.ncbi.nlm.nih.gov/pubmed/37345116
http://dx.doi.org/10.3390/cancers15102779
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