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Effect of Spontaneous Subarachnoid Hemorrhage on Cerebrospinal Fluid Indicators

The cerebrospinal fluid (CSF) analysis in ruptured aneurysms can be greatly affected by subarachnoid hemorrhage (SAH), making the diagnosis of intracranial infection more difficult after surgery. This study aimed to identify the reference value range of CSF in the pathological state following sponta...

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Detalles Bibliográficos
Autores principales: You, Huichao, Li, Wenqi, Chen, Qianxue
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10216332/
https://www.ncbi.nlm.nih.gov/pubmed/37239250
http://dx.doi.org/10.3390/brainsci13050778
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author You, Huichao
Li, Wenqi
Chen, Qianxue
author_facet You, Huichao
Li, Wenqi
Chen, Qianxue
author_sort You, Huichao
collection PubMed
description The cerebrospinal fluid (CSF) analysis in ruptured aneurysms can be greatly affected by subarachnoid hemorrhage (SAH), making the diagnosis of intracranial infection more difficult after surgery. This study aimed to identify the reference value range of CSF in the pathological state following spontaneous SAH. A retrospective analysis of demographic and CSF data of all spontaneous SAH patients treated between January 2018 and January 2023 was conducted. A total of 101 valid CSF specimen data were collected for analysis. Our results indicate that in 95% of patients after spontaneous SAH, the leukocyte count in CSF was less than 880 × 10(6)/L. Additionally, the proportion of neutrophils, lymphocytes, and monocytes did not exceed 75%, 75%, and 15%, respectively, in 95% of the population. Furthermore, in 95% of the specimens, the concentration of chloride, glucose, and protein was >115 mmol/L, >2.2 mmol/L, and <2.3 g/L, respectively. Compared to the normal reference values, the CSF indexes after spontaneous SAH showed significant changes, especially in the leukocyte count, chloride concentration, and glucose concentration. Using “white blood cell count < 880/mm(3), glucose > 2.2 mmol/L, chloride > 115” as the reference values for SAH pathological status is more meaningful for reference purposes.
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spelling pubmed-102163322023-05-27 Effect of Spontaneous Subarachnoid Hemorrhage on Cerebrospinal Fluid Indicators You, Huichao Li, Wenqi Chen, Qianxue Brain Sci Article The cerebrospinal fluid (CSF) analysis in ruptured aneurysms can be greatly affected by subarachnoid hemorrhage (SAH), making the diagnosis of intracranial infection more difficult after surgery. This study aimed to identify the reference value range of CSF in the pathological state following spontaneous SAH. A retrospective analysis of demographic and CSF data of all spontaneous SAH patients treated between January 2018 and January 2023 was conducted. A total of 101 valid CSF specimen data were collected for analysis. Our results indicate that in 95% of patients after spontaneous SAH, the leukocyte count in CSF was less than 880 × 10(6)/L. Additionally, the proportion of neutrophils, lymphocytes, and monocytes did not exceed 75%, 75%, and 15%, respectively, in 95% of the population. Furthermore, in 95% of the specimens, the concentration of chloride, glucose, and protein was >115 mmol/L, >2.2 mmol/L, and <2.3 g/L, respectively. Compared to the normal reference values, the CSF indexes after spontaneous SAH showed significant changes, especially in the leukocyte count, chloride concentration, and glucose concentration. Using “white blood cell count < 880/mm(3), glucose > 2.2 mmol/L, chloride > 115” as the reference values for SAH pathological status is more meaningful for reference purposes. MDPI 2023-05-10 /pmc/articles/PMC10216332/ /pubmed/37239250 http://dx.doi.org/10.3390/brainsci13050778 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
You, Huichao
Li, Wenqi
Chen, Qianxue
Effect of Spontaneous Subarachnoid Hemorrhage on Cerebrospinal Fluid Indicators
title Effect of Spontaneous Subarachnoid Hemorrhage on Cerebrospinal Fluid Indicators
title_full Effect of Spontaneous Subarachnoid Hemorrhage on Cerebrospinal Fluid Indicators
title_fullStr Effect of Spontaneous Subarachnoid Hemorrhage on Cerebrospinal Fluid Indicators
title_full_unstemmed Effect of Spontaneous Subarachnoid Hemorrhage on Cerebrospinal Fluid Indicators
title_short Effect of Spontaneous Subarachnoid Hemorrhage on Cerebrospinal Fluid Indicators
title_sort effect of spontaneous subarachnoid hemorrhage on cerebrospinal fluid indicators
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10216332/
https://www.ncbi.nlm.nih.gov/pubmed/37239250
http://dx.doi.org/10.3390/brainsci13050778
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