Cargando…

Recurrent Differentiated Thyroid Cancer: The Current Treatment Options

SIMPLE SUMMARY: The most appropriate treatment for local/regional recurrent differentiated thyroid cancers (DTC) is surgical excision if feasible, followed by adjuvant radioiodine administration. However, depending on the location or extent of the recurrence, surgical excision may not be possible, t...

Descripción completa

Detalles Bibliográficos
Autores principales: Coca-Pelaz, Andrés, Rodrigo, Juan Pablo, Shah, Jatin P., Nixon, Iain J., Hartl, Dana M., Robbins, K. Thomas, Kowalski, Luiz P., Mäkitie, Antti A., Hamoir, Marc, López, Fernando, Saba, Nabil F., Nuyts, Sandra, Rinaldo, Alessandra, Ferlito, Alfio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10216352/
https://www.ncbi.nlm.nih.gov/pubmed/37345029
http://dx.doi.org/10.3390/cancers15102692
_version_ 1785048277647884288
author Coca-Pelaz, Andrés
Rodrigo, Juan Pablo
Shah, Jatin P.
Nixon, Iain J.
Hartl, Dana M.
Robbins, K. Thomas
Kowalski, Luiz P.
Mäkitie, Antti A.
Hamoir, Marc
López, Fernando
Saba, Nabil F.
Nuyts, Sandra
Rinaldo, Alessandra
Ferlito, Alfio
author_facet Coca-Pelaz, Andrés
Rodrigo, Juan Pablo
Shah, Jatin P.
Nixon, Iain J.
Hartl, Dana M.
Robbins, K. Thomas
Kowalski, Luiz P.
Mäkitie, Antti A.
Hamoir, Marc
López, Fernando
Saba, Nabil F.
Nuyts, Sandra
Rinaldo, Alessandra
Ferlito, Alfio
author_sort Coca-Pelaz, Andrés
collection PubMed
description SIMPLE SUMMARY: The most appropriate treatment for local/regional recurrent differentiated thyroid cancers (DTC) is surgical excision if feasible, followed by adjuvant radioiodine administration. However, depending on the location or extent of the recurrence, surgical excision may not be possible, thus creating a need for alternative therapeutic interventions to maintain the otherwise excellent prognosis for this disease. In light of the increased incidence of this disease and the plethora of available systemic options, a detailed knowledge of the available treatment options is essential for successful management of recurrent DTC. ABSTRACT: Differentiated thyroid carcinomas (DTC) have an excellent prognosis, but this is sometimes overshadowed by tumor recurrences following initial treatment (approximately 15% of cases during follow-up), due to unrecognized disease extent at initial diagnosis or a more aggressive tumor biology, which are the usual risk factors. The possible sites of recurrence are local, regional, or distant. Local and regional recurrences can usually be successfully managed with surgery and radioiodine therapy, as are some isolated distant recurrences, such as bone metastases. If these treatments are not possible, other therapeutic options such as external beam radiation therapy or systemic treatments should be considered. Major advances in systemic treatments have led to improved progression-free survival in patients previously considered for palliative treatments; among these treatments, the most promising results have been achieved with tyrosine kinase inhibitors (TKI). This review attempts to give a comprehensive overview of the current treatment options suited for recurrences and the new treatments that are available in cases where salvage surgery is not possible or in cases resistant to radioiodine.
format Online
Article
Text
id pubmed-10216352
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-102163522023-05-27 Recurrent Differentiated Thyroid Cancer: The Current Treatment Options Coca-Pelaz, Andrés Rodrigo, Juan Pablo Shah, Jatin P. Nixon, Iain J. Hartl, Dana M. Robbins, K. Thomas Kowalski, Luiz P. Mäkitie, Antti A. Hamoir, Marc López, Fernando Saba, Nabil F. Nuyts, Sandra Rinaldo, Alessandra Ferlito, Alfio Cancers (Basel) Review SIMPLE SUMMARY: The most appropriate treatment for local/regional recurrent differentiated thyroid cancers (DTC) is surgical excision if feasible, followed by adjuvant radioiodine administration. However, depending on the location or extent of the recurrence, surgical excision may not be possible, thus creating a need for alternative therapeutic interventions to maintain the otherwise excellent prognosis for this disease. In light of the increased incidence of this disease and the plethora of available systemic options, a detailed knowledge of the available treatment options is essential for successful management of recurrent DTC. ABSTRACT: Differentiated thyroid carcinomas (DTC) have an excellent prognosis, but this is sometimes overshadowed by tumor recurrences following initial treatment (approximately 15% of cases during follow-up), due to unrecognized disease extent at initial diagnosis or a more aggressive tumor biology, which are the usual risk factors. The possible sites of recurrence are local, regional, or distant. Local and regional recurrences can usually be successfully managed with surgery and radioiodine therapy, as are some isolated distant recurrences, such as bone metastases. If these treatments are not possible, other therapeutic options such as external beam radiation therapy or systemic treatments should be considered. Major advances in systemic treatments have led to improved progression-free survival in patients previously considered for palliative treatments; among these treatments, the most promising results have been achieved with tyrosine kinase inhibitors (TKI). This review attempts to give a comprehensive overview of the current treatment options suited for recurrences and the new treatments that are available in cases where salvage surgery is not possible or in cases resistant to radioiodine. MDPI 2023-05-10 /pmc/articles/PMC10216352/ /pubmed/37345029 http://dx.doi.org/10.3390/cancers15102692 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Coca-Pelaz, Andrés
Rodrigo, Juan Pablo
Shah, Jatin P.
Nixon, Iain J.
Hartl, Dana M.
Robbins, K. Thomas
Kowalski, Luiz P.
Mäkitie, Antti A.
Hamoir, Marc
López, Fernando
Saba, Nabil F.
Nuyts, Sandra
Rinaldo, Alessandra
Ferlito, Alfio
Recurrent Differentiated Thyroid Cancer: The Current Treatment Options
title Recurrent Differentiated Thyroid Cancer: The Current Treatment Options
title_full Recurrent Differentiated Thyroid Cancer: The Current Treatment Options
title_fullStr Recurrent Differentiated Thyroid Cancer: The Current Treatment Options
title_full_unstemmed Recurrent Differentiated Thyroid Cancer: The Current Treatment Options
title_short Recurrent Differentiated Thyroid Cancer: The Current Treatment Options
title_sort recurrent differentiated thyroid cancer: the current treatment options
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10216352/
https://www.ncbi.nlm.nih.gov/pubmed/37345029
http://dx.doi.org/10.3390/cancers15102692
work_keys_str_mv AT cocapelazandres recurrentdifferentiatedthyroidcancerthecurrenttreatmentoptions
AT rodrigojuanpablo recurrentdifferentiatedthyroidcancerthecurrenttreatmentoptions
AT shahjatinp recurrentdifferentiatedthyroidcancerthecurrenttreatmentoptions
AT nixoniainj recurrentdifferentiatedthyroidcancerthecurrenttreatmentoptions
AT hartldanam recurrentdifferentiatedthyroidcancerthecurrenttreatmentoptions
AT robbinskthomas recurrentdifferentiatedthyroidcancerthecurrenttreatmentoptions
AT kowalskiluizp recurrentdifferentiatedthyroidcancerthecurrenttreatmentoptions
AT makitieanttia recurrentdifferentiatedthyroidcancerthecurrenttreatmentoptions
AT hamoirmarc recurrentdifferentiatedthyroidcancerthecurrenttreatmentoptions
AT lopezfernando recurrentdifferentiatedthyroidcancerthecurrenttreatmentoptions
AT sabanabilf recurrentdifferentiatedthyroidcancerthecurrenttreatmentoptions
AT nuytssandra recurrentdifferentiatedthyroidcancerthecurrenttreatmentoptions
AT rinaldoalessandra recurrentdifferentiatedthyroidcancerthecurrenttreatmentoptions
AT ferlitoalfio recurrentdifferentiatedthyroidcancerthecurrenttreatmentoptions