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Extracellular Targets to Reduce Excessive Scarring in Response to Tissue Injury

Excessive scar formation is a hallmark of localized and systemic fibrotic disorders. Despite extensive studies to define valid anti-fibrotic targets and develop effective therapeutics, progressive fibrosis remains a significant medical problem. Regardless of the injury type or location of wounded ti...

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Autores principales: Fertala, Jolanta, Wang, Mark L., Rivlin, Michael, Beredjiklian, Pedro K., Abboud, Joseph, Arnold, William V., Fertala, Andrzej
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10216402/
https://www.ncbi.nlm.nih.gov/pubmed/37238628
http://dx.doi.org/10.3390/biom13050758
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author Fertala, Jolanta
Wang, Mark L.
Rivlin, Michael
Beredjiklian, Pedro K.
Abboud, Joseph
Arnold, William V.
Fertala, Andrzej
author_facet Fertala, Jolanta
Wang, Mark L.
Rivlin, Michael
Beredjiklian, Pedro K.
Abboud, Joseph
Arnold, William V.
Fertala, Andrzej
author_sort Fertala, Jolanta
collection PubMed
description Excessive scar formation is a hallmark of localized and systemic fibrotic disorders. Despite extensive studies to define valid anti-fibrotic targets and develop effective therapeutics, progressive fibrosis remains a significant medical problem. Regardless of the injury type or location of wounded tissue, excessive production and accumulation of collagen-rich extracellular matrix is the common denominator of all fibrotic disorders. A long-standing dogma was that anti-fibrotic approaches should focus on overall intracellular processes that drive fibrotic scarring. Because of the poor outcomes of these approaches, scientific efforts now focus on regulating the extracellular components of fibrotic tissues. Crucial extracellular players include cellular receptors of matrix components, macromolecules that form the matrix architecture, auxiliary proteins that facilitate the formation of stiff scar tissue, matricellular proteins, and extracellular vesicles that modulate matrix homeostasis. This review summarizes studies targeting the extracellular aspects of fibrotic tissue synthesis, presents the rationale for these studies, and discusses the progress and limitations of current extracellular approaches to limit fibrotic healing.
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spelling pubmed-102164022023-05-27 Extracellular Targets to Reduce Excessive Scarring in Response to Tissue Injury Fertala, Jolanta Wang, Mark L. Rivlin, Michael Beredjiklian, Pedro K. Abboud, Joseph Arnold, William V. Fertala, Andrzej Biomolecules Review Excessive scar formation is a hallmark of localized and systemic fibrotic disorders. Despite extensive studies to define valid anti-fibrotic targets and develop effective therapeutics, progressive fibrosis remains a significant medical problem. Regardless of the injury type or location of wounded tissue, excessive production and accumulation of collagen-rich extracellular matrix is the common denominator of all fibrotic disorders. A long-standing dogma was that anti-fibrotic approaches should focus on overall intracellular processes that drive fibrotic scarring. Because of the poor outcomes of these approaches, scientific efforts now focus on regulating the extracellular components of fibrotic tissues. Crucial extracellular players include cellular receptors of matrix components, macromolecules that form the matrix architecture, auxiliary proteins that facilitate the formation of stiff scar tissue, matricellular proteins, and extracellular vesicles that modulate matrix homeostasis. This review summarizes studies targeting the extracellular aspects of fibrotic tissue synthesis, presents the rationale for these studies, and discusses the progress and limitations of current extracellular approaches to limit fibrotic healing. MDPI 2023-04-27 /pmc/articles/PMC10216402/ /pubmed/37238628 http://dx.doi.org/10.3390/biom13050758 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Fertala, Jolanta
Wang, Mark L.
Rivlin, Michael
Beredjiklian, Pedro K.
Abboud, Joseph
Arnold, William V.
Fertala, Andrzej
Extracellular Targets to Reduce Excessive Scarring in Response to Tissue Injury
title Extracellular Targets to Reduce Excessive Scarring in Response to Tissue Injury
title_full Extracellular Targets to Reduce Excessive Scarring in Response to Tissue Injury
title_fullStr Extracellular Targets to Reduce Excessive Scarring in Response to Tissue Injury
title_full_unstemmed Extracellular Targets to Reduce Excessive Scarring in Response to Tissue Injury
title_short Extracellular Targets to Reduce Excessive Scarring in Response to Tissue Injury
title_sort extracellular targets to reduce excessive scarring in response to tissue injury
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10216402/
https://www.ncbi.nlm.nih.gov/pubmed/37238628
http://dx.doi.org/10.3390/biom13050758
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