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CTCF and Its Multi-Partner Network for Chromatin Regulation
Architectural proteins are essential epigenetic regulators that play a critical role in organizing chromatin and controlling gene expression. CTCF (CCCTC-binding factor) is a key architectural protein responsible for maintaining the intricate 3D structure of chromatin. Because of its multivalent pro...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10216408/ https://www.ncbi.nlm.nih.gov/pubmed/37408191 http://dx.doi.org/10.3390/cells12101357 |
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author | Del Moral-Morales, Aylin Salgado-Albarrán, Marisol Sánchez-Pérez, Yesennia Wenke, Nina Kerstin Baumbach, Jan Soto-Reyes, Ernesto |
author_facet | Del Moral-Morales, Aylin Salgado-Albarrán, Marisol Sánchez-Pérez, Yesennia Wenke, Nina Kerstin Baumbach, Jan Soto-Reyes, Ernesto |
author_sort | Del Moral-Morales, Aylin |
collection | PubMed |
description | Architectural proteins are essential epigenetic regulators that play a critical role in organizing chromatin and controlling gene expression. CTCF (CCCTC-binding factor) is a key architectural protein responsible for maintaining the intricate 3D structure of chromatin. Because of its multivalent properties and plasticity to bind various sequences, CTCF is similar to a Swiss knife for genome organization. Despite the importance of this protein, its mechanisms of action are not fully elucidated. It has been hypothesized that its versatility is achieved through interaction with multiple partners, forming a complex network that regulates chromatin folding within the nucleus. In this review, we delve into CTCF’s interactions with other molecules involved in epigenetic processes, particularly histone and DNA demethylases, as well as several long non-coding RNAs (lncRNAs) that are able to recruit CTCF. Our review highlights the importance of CTCF partners to shed light on chromatin regulation and pave the way for future exploration of the mechanisms that enable the finely-tuned role of CTCF as a master regulator of chromatin. |
format | Online Article Text |
id | pubmed-10216408 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-102164082023-05-27 CTCF and Its Multi-Partner Network for Chromatin Regulation Del Moral-Morales, Aylin Salgado-Albarrán, Marisol Sánchez-Pérez, Yesennia Wenke, Nina Kerstin Baumbach, Jan Soto-Reyes, Ernesto Cells Review Architectural proteins are essential epigenetic regulators that play a critical role in organizing chromatin and controlling gene expression. CTCF (CCCTC-binding factor) is a key architectural protein responsible for maintaining the intricate 3D structure of chromatin. Because of its multivalent properties and plasticity to bind various sequences, CTCF is similar to a Swiss knife for genome organization. Despite the importance of this protein, its mechanisms of action are not fully elucidated. It has been hypothesized that its versatility is achieved through interaction with multiple partners, forming a complex network that regulates chromatin folding within the nucleus. In this review, we delve into CTCF’s interactions with other molecules involved in epigenetic processes, particularly histone and DNA demethylases, as well as several long non-coding RNAs (lncRNAs) that are able to recruit CTCF. Our review highlights the importance of CTCF partners to shed light on chromatin regulation and pave the way for future exploration of the mechanisms that enable the finely-tuned role of CTCF as a master regulator of chromatin. MDPI 2023-05-10 /pmc/articles/PMC10216408/ /pubmed/37408191 http://dx.doi.org/10.3390/cells12101357 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Del Moral-Morales, Aylin Salgado-Albarrán, Marisol Sánchez-Pérez, Yesennia Wenke, Nina Kerstin Baumbach, Jan Soto-Reyes, Ernesto CTCF and Its Multi-Partner Network for Chromatin Regulation |
title | CTCF and Its Multi-Partner Network for Chromatin Regulation |
title_full | CTCF and Its Multi-Partner Network for Chromatin Regulation |
title_fullStr | CTCF and Its Multi-Partner Network for Chromatin Regulation |
title_full_unstemmed | CTCF and Its Multi-Partner Network for Chromatin Regulation |
title_short | CTCF and Its Multi-Partner Network for Chromatin Regulation |
title_sort | ctcf and its multi-partner network for chromatin regulation |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10216408/ https://www.ncbi.nlm.nih.gov/pubmed/37408191 http://dx.doi.org/10.3390/cells12101357 |
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