Cargando…
Impact on Patient Management of a Novel Host Response Test for Distinguishing Bacterial and Viral Infections: Real World Evidence from the Urgent Care Setting
Antibiotic overuse and underuse are prevalent in urgent care settings, driven in part by diagnostic uncertainty. A host-based test for distinguishing bacterial and viral infections (MeMed BV) has been clinically validated previously. Here we examined how BV impacts antibiotic prescription in a real-...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10216409/ https://www.ncbi.nlm.nih.gov/pubmed/37239167 http://dx.doi.org/10.3390/biomedicines11051498 |
_version_ | 1785048291242672128 |
---|---|
author | Kalmovich, Boaz Rahamim-Cohen, Daniella Shapiro Ben David, Shirley |
author_facet | Kalmovich, Boaz Rahamim-Cohen, Daniella Shapiro Ben David, Shirley |
author_sort | Kalmovich, Boaz |
collection | PubMed |
description | Antibiotic overuse and underuse are prevalent in urgent care settings, driven in part by diagnostic uncertainty. A host-based test for distinguishing bacterial and viral infections (MeMed BV) has been clinically validated previously. Here we examined how BV impacts antibiotic prescription in a real-world setting. The intention to treat with antibiotics before the receipt of a BV result was compared with practice after the receipt of a BV result at three urgent care centers. The analysis included 152 patients, 57.9% children and 50.7% female. In total, 131 (86.2%) had a bacterial or viral BV result. Physicians were uncertain about prescription for 38 (29.0%) patients and for 30 (78.9%) of these cases, subsequently acted in accordance with the BV result. Physicians intended to prescribe antibiotics to 39 (29.8%) patients, of whom 17 (43.6%) had bacterial BV results. Among the remaining 22 patients with viral BV results, antibiotic prescriptions were reduced by 40.9%. Overall, the physician prescribed in accordance with BV results in 81.7% of all cases (p < 0.05). In total, the physicians reported that BV supported or altered their decision making in 87.0% of cases (p < 0.05). BV impacts patient management in real-world settings, supporting appropriate antibiotic use. |
format | Online Article Text |
id | pubmed-10216409 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-102164092023-05-27 Impact on Patient Management of a Novel Host Response Test for Distinguishing Bacterial and Viral Infections: Real World Evidence from the Urgent Care Setting Kalmovich, Boaz Rahamim-Cohen, Daniella Shapiro Ben David, Shirley Biomedicines Article Antibiotic overuse and underuse are prevalent in urgent care settings, driven in part by diagnostic uncertainty. A host-based test for distinguishing bacterial and viral infections (MeMed BV) has been clinically validated previously. Here we examined how BV impacts antibiotic prescription in a real-world setting. The intention to treat with antibiotics before the receipt of a BV result was compared with practice after the receipt of a BV result at three urgent care centers. The analysis included 152 patients, 57.9% children and 50.7% female. In total, 131 (86.2%) had a bacterial or viral BV result. Physicians were uncertain about prescription for 38 (29.0%) patients and for 30 (78.9%) of these cases, subsequently acted in accordance with the BV result. Physicians intended to prescribe antibiotics to 39 (29.8%) patients, of whom 17 (43.6%) had bacterial BV results. Among the remaining 22 patients with viral BV results, antibiotic prescriptions were reduced by 40.9%. Overall, the physician prescribed in accordance with BV results in 81.7% of all cases (p < 0.05). In total, the physicians reported that BV supported or altered their decision making in 87.0% of cases (p < 0.05). BV impacts patient management in real-world settings, supporting appropriate antibiotic use. MDPI 2023-05-22 /pmc/articles/PMC10216409/ /pubmed/37239167 http://dx.doi.org/10.3390/biomedicines11051498 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Kalmovich, Boaz Rahamim-Cohen, Daniella Shapiro Ben David, Shirley Impact on Patient Management of a Novel Host Response Test for Distinguishing Bacterial and Viral Infections: Real World Evidence from the Urgent Care Setting |
title | Impact on Patient Management of a Novel Host Response Test for Distinguishing Bacterial and Viral Infections: Real World Evidence from the Urgent Care Setting |
title_full | Impact on Patient Management of a Novel Host Response Test for Distinguishing Bacterial and Viral Infections: Real World Evidence from the Urgent Care Setting |
title_fullStr | Impact on Patient Management of a Novel Host Response Test for Distinguishing Bacterial and Viral Infections: Real World Evidence from the Urgent Care Setting |
title_full_unstemmed | Impact on Patient Management of a Novel Host Response Test for Distinguishing Bacterial and Viral Infections: Real World Evidence from the Urgent Care Setting |
title_short | Impact on Patient Management of a Novel Host Response Test for Distinguishing Bacterial and Viral Infections: Real World Evidence from the Urgent Care Setting |
title_sort | impact on patient management of a novel host response test for distinguishing bacterial and viral infections: real world evidence from the urgent care setting |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10216409/ https://www.ncbi.nlm.nih.gov/pubmed/37239167 http://dx.doi.org/10.3390/biomedicines11051498 |
work_keys_str_mv | AT kalmovichboaz impactonpatientmanagementofanovelhostresponsetestfordistinguishingbacterialandviralinfectionsrealworldevidencefromtheurgentcaresetting AT rahamimcohendaniella impactonpatientmanagementofanovelhostresponsetestfordistinguishingbacterialandviralinfectionsrealworldevidencefromtheurgentcaresetting AT shapirobendavidshirley impactonpatientmanagementofanovelhostresponsetestfordistinguishingbacterialandviralinfectionsrealworldevidencefromtheurgentcaresetting |