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Liquid Biopsy in Early-Stage Lung Cancer: Current and Future Clinical Applications
SIMPLE SUMMARY: Early-stage disease non-small cell lung cancer has better outcomes than advanced disease, but 5-year survival rates can drop to approximately 50% in cases of increased tumor size, local extension, or nodal spread. The use of liquid biopsies to enhance diagnosis, optimize perioperativ...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10216452/ https://www.ncbi.nlm.nih.gov/pubmed/37345038 http://dx.doi.org/10.3390/cancers15102702 |
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author | Vandekerckhove, Olivia Cuppens, Kristof Pat, Karin Du Pont, Bert Froyen, Guy Maes, Brigitte |
author_facet | Vandekerckhove, Olivia Cuppens, Kristof Pat, Karin Du Pont, Bert Froyen, Guy Maes, Brigitte |
author_sort | Vandekerckhove, Olivia |
collection | PubMed |
description | SIMPLE SUMMARY: Early-stage disease non-small cell lung cancer has better outcomes than advanced disease, but 5-year survival rates can drop to approximately 50% in cases of increased tumor size, local extension, or nodal spread. The use of liquid biopsies to enhance diagnosis, optimize perioperative systemic treatments, and allow early detection of relapse is a possible strategy to reduce this burden. This review aims to present the current evidence on clinical applications of liquid biopsies in early-stage non-small cell lung cancer and highlight opportunities for future applications. ABSTRACT: Lung cancer remains the leading cause of cancer death worldwide, with the majority of cases diagnosed in an advanced stage. Early-stage disease non-small cell lung cancer (NSCLC) has a better outcome, nevertheless the 5-year survival rates drop from 60% for stage IIA to 36% for stage IIIA disease. Early detection and optimized perioperative systemic treatment are frontrunner strategies to reduce this burden. The rapid advancements in molecular diagnostics as well as the growing availability of targeted therapies call for the most efficient detection of actionable biomarkers. Liquid biopsies have already proven their added value in the management of advanced NSCLC but can also optimize patient care in early-stage NSCLC. In addition to having known diagnostic benefits of speed, accessibility, and enhanced biomarker detection compared to tissue biopsy, liquid biopsy could be implemented for screening, diagnostic, and prognostic purposes. Furthermore, liquid biopsy can optimize therapeutic management by overcoming the issue of tumor heterogeneity, monitoring tumor burden, and detecting minimal residual disease (MRD), i.e., the presence of tumor-specific ctDNA, post-operatively. The latter is strongly prognostic and is likely to become a guidance in the postsurgical management. In this review, we present the current evidence on the clinical utility of liquid biopsy in early-stage lung cancer, discuss a selection of key trials, and suggest future applications. |
format | Online Article Text |
id | pubmed-10216452 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-102164522023-05-27 Liquid Biopsy in Early-Stage Lung Cancer: Current and Future Clinical Applications Vandekerckhove, Olivia Cuppens, Kristof Pat, Karin Du Pont, Bert Froyen, Guy Maes, Brigitte Cancers (Basel) Review SIMPLE SUMMARY: Early-stage disease non-small cell lung cancer has better outcomes than advanced disease, but 5-year survival rates can drop to approximately 50% in cases of increased tumor size, local extension, or nodal spread. The use of liquid biopsies to enhance diagnosis, optimize perioperative systemic treatments, and allow early detection of relapse is a possible strategy to reduce this burden. This review aims to present the current evidence on clinical applications of liquid biopsies in early-stage non-small cell lung cancer and highlight opportunities for future applications. ABSTRACT: Lung cancer remains the leading cause of cancer death worldwide, with the majority of cases diagnosed in an advanced stage. Early-stage disease non-small cell lung cancer (NSCLC) has a better outcome, nevertheless the 5-year survival rates drop from 60% for stage IIA to 36% for stage IIIA disease. Early detection and optimized perioperative systemic treatment are frontrunner strategies to reduce this burden. The rapid advancements in molecular diagnostics as well as the growing availability of targeted therapies call for the most efficient detection of actionable biomarkers. Liquid biopsies have already proven their added value in the management of advanced NSCLC but can also optimize patient care in early-stage NSCLC. In addition to having known diagnostic benefits of speed, accessibility, and enhanced biomarker detection compared to tissue biopsy, liquid biopsy could be implemented for screening, diagnostic, and prognostic purposes. Furthermore, liquid biopsy can optimize therapeutic management by overcoming the issue of tumor heterogeneity, monitoring tumor burden, and detecting minimal residual disease (MRD), i.e., the presence of tumor-specific ctDNA, post-operatively. The latter is strongly prognostic and is likely to become a guidance in the postsurgical management. In this review, we present the current evidence on the clinical utility of liquid biopsy in early-stage lung cancer, discuss a selection of key trials, and suggest future applications. MDPI 2023-05-10 /pmc/articles/PMC10216452/ /pubmed/37345038 http://dx.doi.org/10.3390/cancers15102702 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Vandekerckhove, Olivia Cuppens, Kristof Pat, Karin Du Pont, Bert Froyen, Guy Maes, Brigitte Liquid Biopsy in Early-Stage Lung Cancer: Current and Future Clinical Applications |
title | Liquid Biopsy in Early-Stage Lung Cancer: Current and Future Clinical Applications |
title_full | Liquid Biopsy in Early-Stage Lung Cancer: Current and Future Clinical Applications |
title_fullStr | Liquid Biopsy in Early-Stage Lung Cancer: Current and Future Clinical Applications |
title_full_unstemmed | Liquid Biopsy in Early-Stage Lung Cancer: Current and Future Clinical Applications |
title_short | Liquid Biopsy in Early-Stage Lung Cancer: Current and Future Clinical Applications |
title_sort | liquid biopsy in early-stage lung cancer: current and future clinical applications |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10216452/ https://www.ncbi.nlm.nih.gov/pubmed/37345038 http://dx.doi.org/10.3390/cancers15102702 |
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