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The Impact of Maternal Probiotics on Intestinal Vitamin D Receptor Expression in Early Life

Vitamin D signaling via the Vitamin D Receptor (VDR) has been shown to protect against intestinal inflammation. Previous studies have also reported the mutual interactions of intestinal VDR and the microbiome, indicating a potential role of probiotics in modulating VDR expression. In preterm infants...

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Autores principales: Sharma, Anita, Yu, Yueyue, Lu, Jing, Lu, Lei, Zhang, Yong-Guo, Xia, Yinglin, Sun, Jun, Claud, Erika C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10216467/
https://www.ncbi.nlm.nih.gov/pubmed/37238716
http://dx.doi.org/10.3390/biom13050847
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author Sharma, Anita
Yu, Yueyue
Lu, Jing
Lu, Lei
Zhang, Yong-Guo
Xia, Yinglin
Sun, Jun
Claud, Erika C.
author_facet Sharma, Anita
Yu, Yueyue
Lu, Jing
Lu, Lei
Zhang, Yong-Guo
Xia, Yinglin
Sun, Jun
Claud, Erika C.
author_sort Sharma, Anita
collection PubMed
description Vitamin D signaling via the Vitamin D Receptor (VDR) has been shown to protect against intestinal inflammation. Previous studies have also reported the mutual interactions of intestinal VDR and the microbiome, indicating a potential role of probiotics in modulating VDR expression. In preterm infants, although probiotics have been shown to reduce the incidence of necrotizing enterocolitis (NEC), they are not currently recommended by the FDA due to potential risks in this population. No previous studies have delved into the effect of maternally administered probiotics on intestinal VDR expression in early life. Using an infancy mouse model, we found that young mice exposed to maternally administered probiotics (SPF/LB) maintained higher colonic VDR expression than our unexposed mice (SPF) in the face of a systemic inflammatory stimulus. These findings indicate a potential role for microbiome-modulating therapies in preventing diseases such as NEC through the enhancement of VDR signaling.
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spelling pubmed-102164672023-05-27 The Impact of Maternal Probiotics on Intestinal Vitamin D Receptor Expression in Early Life Sharma, Anita Yu, Yueyue Lu, Jing Lu, Lei Zhang, Yong-Guo Xia, Yinglin Sun, Jun Claud, Erika C. Biomolecules Communication Vitamin D signaling via the Vitamin D Receptor (VDR) has been shown to protect against intestinal inflammation. Previous studies have also reported the mutual interactions of intestinal VDR and the microbiome, indicating a potential role of probiotics in modulating VDR expression. In preterm infants, although probiotics have been shown to reduce the incidence of necrotizing enterocolitis (NEC), they are not currently recommended by the FDA due to potential risks in this population. No previous studies have delved into the effect of maternally administered probiotics on intestinal VDR expression in early life. Using an infancy mouse model, we found that young mice exposed to maternally administered probiotics (SPF/LB) maintained higher colonic VDR expression than our unexposed mice (SPF) in the face of a systemic inflammatory stimulus. These findings indicate a potential role for microbiome-modulating therapies in preventing diseases such as NEC through the enhancement of VDR signaling. MDPI 2023-05-16 /pmc/articles/PMC10216467/ /pubmed/37238716 http://dx.doi.org/10.3390/biom13050847 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Sharma, Anita
Yu, Yueyue
Lu, Jing
Lu, Lei
Zhang, Yong-Guo
Xia, Yinglin
Sun, Jun
Claud, Erika C.
The Impact of Maternal Probiotics on Intestinal Vitamin D Receptor Expression in Early Life
title The Impact of Maternal Probiotics on Intestinal Vitamin D Receptor Expression in Early Life
title_full The Impact of Maternal Probiotics on Intestinal Vitamin D Receptor Expression in Early Life
title_fullStr The Impact of Maternal Probiotics on Intestinal Vitamin D Receptor Expression in Early Life
title_full_unstemmed The Impact of Maternal Probiotics on Intestinal Vitamin D Receptor Expression in Early Life
title_short The Impact of Maternal Probiotics on Intestinal Vitamin D Receptor Expression in Early Life
title_sort impact of maternal probiotics on intestinal vitamin d receptor expression in early life
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10216467/
https://www.ncbi.nlm.nih.gov/pubmed/37238716
http://dx.doi.org/10.3390/biom13050847
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