Heparin-Based Hydrogel Micropatches with Human Adipose-Derived Stem Cells: A Promising Therapeutic Approach for Neuropathic Pain Relief

This study explores the therapeutic efficacy of heparin-based hydrogel micropatches containing human adipose-derived stem cells (hASCs) in treating neuropathic pain caused by nerve damage. Our results showed that hASCs exhibited neuroregenerative and pain-relieving effects when used with heparin-bas...

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Autores principales: Lee, HyeYeong, Tae, GiYoong, Hwang, SaeYeon, Wee, SungWon, Ha, Yoon, Lee, Hye-Lan, Shin, DongAh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10216470/
https://www.ncbi.nlm.nih.gov/pubmed/37239107
http://dx.doi.org/10.3390/biomedicines11051436
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author Lee, HyeYeong
Tae, GiYoong
Hwang, SaeYeon
Wee, SungWon
Ha, Yoon
Lee, Hye-Lan
Shin, DongAh
author_facet Lee, HyeYeong
Tae, GiYoong
Hwang, SaeYeon
Wee, SungWon
Ha, Yoon
Lee, Hye-Lan
Shin, DongAh
author_sort Lee, HyeYeong
collection PubMed
description This study explores the therapeutic efficacy of heparin-based hydrogel micropatches containing human adipose-derived stem cells (hASCs) in treating neuropathic pain caused by nerve damage. Our results showed that hASCs exhibited neuroregenerative and pain-relieving effects when used with heparin-based hydrogel micropatches in the neuropathic pain animal model. The use of this combination also produced enhanced cell viability and nerve regeneration. We conducted various neurological behavioral tests, dynamic plantar tests, histological examinations, and neuroelectrophysiological examinations to confirm the therapeutic effect. Our findings suggest that this approach could maximize therapeutic efficacy and improve the quality of life for patients suffering from neuropathic pain.
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spelling pubmed-102164702023-05-27 Heparin-Based Hydrogel Micropatches with Human Adipose-Derived Stem Cells: A Promising Therapeutic Approach for Neuropathic Pain Relief Lee, HyeYeong Tae, GiYoong Hwang, SaeYeon Wee, SungWon Ha, Yoon Lee, Hye-Lan Shin, DongAh Biomedicines Article This study explores the therapeutic efficacy of heparin-based hydrogel micropatches containing human adipose-derived stem cells (hASCs) in treating neuropathic pain caused by nerve damage. Our results showed that hASCs exhibited neuroregenerative and pain-relieving effects when used with heparin-based hydrogel micropatches in the neuropathic pain animal model. The use of this combination also produced enhanced cell viability and nerve regeneration. We conducted various neurological behavioral tests, dynamic plantar tests, histological examinations, and neuroelectrophysiological examinations to confirm the therapeutic effect. Our findings suggest that this approach could maximize therapeutic efficacy and improve the quality of life for patients suffering from neuropathic pain. MDPI 2023-05-12 /pmc/articles/PMC10216470/ /pubmed/37239107 http://dx.doi.org/10.3390/biomedicines11051436 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Lee, HyeYeong
Tae, GiYoong
Hwang, SaeYeon
Wee, SungWon
Ha, Yoon
Lee, Hye-Lan
Shin, DongAh
Heparin-Based Hydrogel Micropatches with Human Adipose-Derived Stem Cells: A Promising Therapeutic Approach for Neuropathic Pain Relief
title Heparin-Based Hydrogel Micropatches with Human Adipose-Derived Stem Cells: A Promising Therapeutic Approach for Neuropathic Pain Relief
title_full Heparin-Based Hydrogel Micropatches with Human Adipose-Derived Stem Cells: A Promising Therapeutic Approach for Neuropathic Pain Relief
title_fullStr Heparin-Based Hydrogel Micropatches with Human Adipose-Derived Stem Cells: A Promising Therapeutic Approach for Neuropathic Pain Relief
title_full_unstemmed Heparin-Based Hydrogel Micropatches with Human Adipose-Derived Stem Cells: A Promising Therapeutic Approach for Neuropathic Pain Relief
title_short Heparin-Based Hydrogel Micropatches with Human Adipose-Derived Stem Cells: A Promising Therapeutic Approach for Neuropathic Pain Relief
title_sort heparin-based hydrogel micropatches with human adipose-derived stem cells: a promising therapeutic approach for neuropathic pain relief
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10216470/
https://www.ncbi.nlm.nih.gov/pubmed/37239107
http://dx.doi.org/10.3390/biomedicines11051436
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