Cargando…
Multi-Omic Analysis of CIC’s Functional Networks Reveals Novel Interaction Partners and a Potential Role in Mitotic Fidelity
SIMPLE SUMMARY: Capicua (CIC) is a gene that is frequently mutated in several cancer types, including stomach cancers and certain subtypes of brain tumours and sarcomas. CIC, the protein encoded by the CIC gene, has been shown to play a multitude of roles in both normal and cancer cell functions; ho...
Autores principales: | Takemon, Yuka, LeBlanc, Véronique G., Song, Jungeun, Chan, Susanna Y., Lee, Stephen Dongsoo, Trinh, Diane L., Ahmad, Shiekh Tanveer, Brothers, William R., Corbett, Richard D., Gagliardi, Alessia, Moradian, Annie, Cairncross, J. Gregory, Yip, Stephen, Aparicio, Samuel A. J. R., Chan, Jennifer A., Hughes, Christopher S., Morin, Gregg B., Gorski, Sharon M., Chittaranjan, Suganthi, Marra, Marco A. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10216487/ https://www.ncbi.nlm.nih.gov/pubmed/37345142 http://dx.doi.org/10.3390/cancers15102805 |
Ejemplares similares
-
Mutations in CIC and IDH1 cooperatively regulate 2-hydroxyglutarate levels and cell clonogenicity
por: Chittaranjan, Suganthi, et al.
Publicado: (2014) -
Comparative transcriptome analysis of isogenic cell line models and primary cancers links capicua (CIC) loss to activation of the MAPK signalling cascade
por: LeBlanc, Veronique G, et al.
Publicado: (2017) -
Integrative multi‐omic analysis reveals neurodevelopmental gene dysregulation in
CIC
‐knockout and
IDH1
‐mutant cells
por: Lee, Stephen D, et al.
Publicado: (2021) -
GRETTA: an R package for mapping in silico genetic interaction and essentiality networks
por: Takemon, Yuka, et al.
Publicado: (2023) -
JAK/STAT PATHWAY COOPERATES WITH CIC FUSIONS TO DRIVE CIC-REARRANGED SARCOMAS
por: Kaloti, R K, et al.
Publicado: (2023)