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Genome Editing and Cardiac Arrhythmias

This article reviews progress in the field of cardiac genome editing, in particular, its potential utility in treating cardiac arrhythmias. First, we discuss genome editing methods by which DNA can be disrupted, inserted, deleted, or corrected in cardiomyocytes. Second, we provide an overview of in...

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Detalles Bibliográficos
Autores principales: Moore, Oliver M., Ho, Kevin S., Copeland, Juwan S., Parthasarathy, Vaidya, Wehrens, Xander H. T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10216508/
https://www.ncbi.nlm.nih.gov/pubmed/37408197
http://dx.doi.org/10.3390/cells12101363
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author Moore, Oliver M.
Ho, Kevin S.
Copeland, Juwan S.
Parthasarathy, Vaidya
Wehrens, Xander H. T.
author_facet Moore, Oliver M.
Ho, Kevin S.
Copeland, Juwan S.
Parthasarathy, Vaidya
Wehrens, Xander H. T.
author_sort Moore, Oliver M.
collection PubMed
description This article reviews progress in the field of cardiac genome editing, in particular, its potential utility in treating cardiac arrhythmias. First, we discuss genome editing methods by which DNA can be disrupted, inserted, deleted, or corrected in cardiomyocytes. Second, we provide an overview of in vivo genome editing in preclinical models of heritable and acquired arrhythmias. Third, we discuss recent advancements in cardiac gene transfer, including delivery methods, gene expression optimization, and potential adverse effects associated with therapeutic somatic genome editing. While genome editing for cardiac arrhythmias is still in its infancy, this approach holds great promise, especially for inherited arrhythmia syndromes with a defined genetic defect.
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spelling pubmed-102165082023-05-27 Genome Editing and Cardiac Arrhythmias Moore, Oliver M. Ho, Kevin S. Copeland, Juwan S. Parthasarathy, Vaidya Wehrens, Xander H. T. Cells Review This article reviews progress in the field of cardiac genome editing, in particular, its potential utility in treating cardiac arrhythmias. First, we discuss genome editing methods by which DNA can be disrupted, inserted, deleted, or corrected in cardiomyocytes. Second, we provide an overview of in vivo genome editing in preclinical models of heritable and acquired arrhythmias. Third, we discuss recent advancements in cardiac gene transfer, including delivery methods, gene expression optimization, and potential adverse effects associated with therapeutic somatic genome editing. While genome editing for cardiac arrhythmias is still in its infancy, this approach holds great promise, especially for inherited arrhythmia syndromes with a defined genetic defect. MDPI 2023-05-11 /pmc/articles/PMC10216508/ /pubmed/37408197 http://dx.doi.org/10.3390/cells12101363 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Moore, Oliver M.
Ho, Kevin S.
Copeland, Juwan S.
Parthasarathy, Vaidya
Wehrens, Xander H. T.
Genome Editing and Cardiac Arrhythmias
title Genome Editing and Cardiac Arrhythmias
title_full Genome Editing and Cardiac Arrhythmias
title_fullStr Genome Editing and Cardiac Arrhythmias
title_full_unstemmed Genome Editing and Cardiac Arrhythmias
title_short Genome Editing and Cardiac Arrhythmias
title_sort genome editing and cardiac arrhythmias
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10216508/
https://www.ncbi.nlm.nih.gov/pubmed/37408197
http://dx.doi.org/10.3390/cells12101363
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