Cargando…
Genome Editing and Cardiac Arrhythmias
This article reviews progress in the field of cardiac genome editing, in particular, its potential utility in treating cardiac arrhythmias. First, we discuss genome editing methods by which DNA can be disrupted, inserted, deleted, or corrected in cardiomyocytes. Second, we provide an overview of in...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10216508/ https://www.ncbi.nlm.nih.gov/pubmed/37408197 http://dx.doi.org/10.3390/cells12101363 |
_version_ | 1785048315140767744 |
---|---|
author | Moore, Oliver M. Ho, Kevin S. Copeland, Juwan S. Parthasarathy, Vaidya Wehrens, Xander H. T. |
author_facet | Moore, Oliver M. Ho, Kevin S. Copeland, Juwan S. Parthasarathy, Vaidya Wehrens, Xander H. T. |
author_sort | Moore, Oliver M. |
collection | PubMed |
description | This article reviews progress in the field of cardiac genome editing, in particular, its potential utility in treating cardiac arrhythmias. First, we discuss genome editing methods by which DNA can be disrupted, inserted, deleted, or corrected in cardiomyocytes. Second, we provide an overview of in vivo genome editing in preclinical models of heritable and acquired arrhythmias. Third, we discuss recent advancements in cardiac gene transfer, including delivery methods, gene expression optimization, and potential adverse effects associated with therapeutic somatic genome editing. While genome editing for cardiac arrhythmias is still in its infancy, this approach holds great promise, especially for inherited arrhythmia syndromes with a defined genetic defect. |
format | Online Article Text |
id | pubmed-10216508 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-102165082023-05-27 Genome Editing and Cardiac Arrhythmias Moore, Oliver M. Ho, Kevin S. Copeland, Juwan S. Parthasarathy, Vaidya Wehrens, Xander H. T. Cells Review This article reviews progress in the field of cardiac genome editing, in particular, its potential utility in treating cardiac arrhythmias. First, we discuss genome editing methods by which DNA can be disrupted, inserted, deleted, or corrected in cardiomyocytes. Second, we provide an overview of in vivo genome editing in preclinical models of heritable and acquired arrhythmias. Third, we discuss recent advancements in cardiac gene transfer, including delivery methods, gene expression optimization, and potential adverse effects associated with therapeutic somatic genome editing. While genome editing for cardiac arrhythmias is still in its infancy, this approach holds great promise, especially for inherited arrhythmia syndromes with a defined genetic defect. MDPI 2023-05-11 /pmc/articles/PMC10216508/ /pubmed/37408197 http://dx.doi.org/10.3390/cells12101363 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Moore, Oliver M. Ho, Kevin S. Copeland, Juwan S. Parthasarathy, Vaidya Wehrens, Xander H. T. Genome Editing and Cardiac Arrhythmias |
title | Genome Editing and Cardiac Arrhythmias |
title_full | Genome Editing and Cardiac Arrhythmias |
title_fullStr | Genome Editing and Cardiac Arrhythmias |
title_full_unstemmed | Genome Editing and Cardiac Arrhythmias |
title_short | Genome Editing and Cardiac Arrhythmias |
title_sort | genome editing and cardiac arrhythmias |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10216508/ https://www.ncbi.nlm.nih.gov/pubmed/37408197 http://dx.doi.org/10.3390/cells12101363 |
work_keys_str_mv | AT mooreoliverm genomeeditingandcardiacarrhythmias AT hokevins genomeeditingandcardiacarrhythmias AT copelandjuwans genomeeditingandcardiacarrhythmias AT parthasarathyvaidya genomeeditingandcardiacarrhythmias AT wehrensxanderht genomeeditingandcardiacarrhythmias |