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PAI-1 Overexpression in Valvular Interstitial Cells Contributes to Hypofibrinolysis in Aortic Stenosis

Aortic stenosis (AS) is associated with hypofibrinolysis, but its mechanism is poorly understood. We investigated whether LDL cholesterol affects plasminogen activator inhibitor 1 (PAI-1) expression, which may contribute to hypofibrinolysis in AS. Stenotic valves were obtained from 75 severe AS pati...

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Detalles Bibliográficos
Autores principales:	Kopytek, Magdalena, Ząbczyk, Michał, Mazur, Piotr, Undas, Anetta, Natorska, Joanna
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Communication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10216522/ https://www.ncbi.nlm.nih.gov/pubmed/37408236 http://dx.doi.org/10.3390/cells12101402

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