mRNA-Lipid Nanoparticle (LNP) Delivery of Humanized EpCAM-CD3 Bispecific Antibody Significantly Blocks Colorectal Cancer Tumor Growth

SIMPLE SUMMARY: Colorectal cancer is one of the most common cancers worldwide, and novel treatments are urgently needed to improve treatment for cancer patients. In this report, three different designs of humanized EpCAM-CD3 antibodies were engineered and tested against colorectal tumors. The antibo...

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Detalles Bibliográficos
Autores principales: Golubovskaya, Vita, Sienkiewicz, John, Sun, Jinying, Huang, Yanwei, Hu, Liang, Zhou, Hua, Harto, Hizkia, Xu, Shirley, Berahovich, Robert, Bodmer, Walter, Wu, Lijun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10216523/
https://www.ncbi.nlm.nih.gov/pubmed/37345198
http://dx.doi.org/10.3390/cancers15102860

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