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Preclinical Validation of an Advanced Therapy Medicinal Product Based on Cytotoxic T Lymphocytes Specific for Mutated Nucleophosmin (NPM1(mut)) for the Treatment of NPM1(mut)-Acute Myeloid Leukemia

SIMPLE SUMMARY: Nearly 30% of adult acute myeloid leukemias (AML) harbor mutations of the nucleophosmin (NPM1) gene. These forms have a favorable outcome but, despite notable treatment advances, about 50% of patients still die of progressive disease. Thus, identification of new therapeutic opportuni...

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Detalles Bibliográficos
Autores principales:	De Cicco, Marica, Lagreca, Ivana, Basso, Sabrina, Barozzi, Patrizia, Muscianisi, Stella, Bianco, Alba, Riva, Giovanni, Di Vincenzo, Sara, Pulvirenti, Chiara, Sapuppo, Davide, Siciliano, Mariangela, Rosti, Vittorio, Candoni, Anna, Zecca, Marco, Forghieri, Fabio, Luppi, Mario, Comoli, Patrizia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10216567/ https://www.ncbi.nlm.nih.gov/pubmed/37345068 http://dx.doi.org/10.3390/cancers15102731

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