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Gold vs. Silver Colloidal Nanoparticle Films for Optimized SERS Detection of Propranolol and Electrochemical-SERS Analyses

The increasing pollution of surface and groundwater bodies by pharmaceuticals is a general environmental problem requiring routine monitoring. Conventional analytical techniques used to quantify traces of pharmaceuticals are relatively expensive and generally demand long analysis times, associated w...

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Autores principales: Muntean, Cristina M., Cuibus, Denisa, Boca, Sanda, Falamas, Alexandra, Tosa, Nicoleta, Brezeştean, Ioana Andreea, Bende, Attila, Barbu-Tudoran, Lucian, Moldovan, Rebeca, Bodoki, Ede, Farcǎu, Cosmin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10216585/
https://www.ncbi.nlm.nih.gov/pubmed/37232891
http://dx.doi.org/10.3390/bios13050530
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author Muntean, Cristina M.
Cuibus, Denisa
Boca, Sanda
Falamas, Alexandra
Tosa, Nicoleta
Brezeştean, Ioana Andreea
Bende, Attila
Barbu-Tudoran, Lucian
Moldovan, Rebeca
Bodoki, Ede
Farcǎu, Cosmin
author_facet Muntean, Cristina M.
Cuibus, Denisa
Boca, Sanda
Falamas, Alexandra
Tosa, Nicoleta
Brezeştean, Ioana Andreea
Bende, Attila
Barbu-Tudoran, Lucian
Moldovan, Rebeca
Bodoki, Ede
Farcǎu, Cosmin
author_sort Muntean, Cristina M.
collection PubMed
description The increasing pollution of surface and groundwater bodies by pharmaceuticals is a general environmental problem requiring routine monitoring. Conventional analytical techniques used to quantify traces of pharmaceuticals are relatively expensive and generally demand long analysis times, associated with difficulties in performing field analyses. Propranolol, a widely used β-blocker, is representative of an emerging class of pharmaceutical pollutants with a noticeable presence in the aquatic environment. In this context, we focused on developing an innovative, highly accessible analytical platform based on self-assembled metal colloidal nanoparticle films for the fast and sensitive detection of propranolol based on Surface Enhanced Raman Spectroscopy (SERS). The ideal nature of the metal used as the active SERS substrate was investigated by comparing silver and gold self-assembled colloidal nanoparticle films, and the improved enhancement observed on the gold substrate was discussed and supported by Density Functional Theory calculations, optical spectra analyses, and Finite-Difference Time-Domain simulations. Next, direct detection of propranolol at low concentrations was demonstrated, reaching the ppb regime. Finally, we showed that the self-assembled gold nanoparticle films could be successfully used as working electrodes in electrochemical-SERS analyses, opening the possibility of implementing them in a wide array of analytical applications and fundamental studies. This study reports for the first time a direct comparison between gold and silver nanoparticle films and, thus, contributes to a more rational design of nanoparticle-based SERS substrates for sensing applications.
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spelling pubmed-102165852023-05-27 Gold vs. Silver Colloidal Nanoparticle Films for Optimized SERS Detection of Propranolol and Electrochemical-SERS Analyses Muntean, Cristina M. Cuibus, Denisa Boca, Sanda Falamas, Alexandra Tosa, Nicoleta Brezeştean, Ioana Andreea Bende, Attila Barbu-Tudoran, Lucian Moldovan, Rebeca Bodoki, Ede Farcǎu, Cosmin Biosensors (Basel) Article The increasing pollution of surface and groundwater bodies by pharmaceuticals is a general environmental problem requiring routine monitoring. Conventional analytical techniques used to quantify traces of pharmaceuticals are relatively expensive and generally demand long analysis times, associated with difficulties in performing field analyses. Propranolol, a widely used β-blocker, is representative of an emerging class of pharmaceutical pollutants with a noticeable presence in the aquatic environment. In this context, we focused on developing an innovative, highly accessible analytical platform based on self-assembled metal colloidal nanoparticle films for the fast and sensitive detection of propranolol based on Surface Enhanced Raman Spectroscopy (SERS). The ideal nature of the metal used as the active SERS substrate was investigated by comparing silver and gold self-assembled colloidal nanoparticle films, and the improved enhancement observed on the gold substrate was discussed and supported by Density Functional Theory calculations, optical spectra analyses, and Finite-Difference Time-Domain simulations. Next, direct detection of propranolol at low concentrations was demonstrated, reaching the ppb regime. Finally, we showed that the self-assembled gold nanoparticle films could be successfully used as working electrodes in electrochemical-SERS analyses, opening the possibility of implementing them in a wide array of analytical applications and fundamental studies. This study reports for the first time a direct comparison between gold and silver nanoparticle films and, thus, contributes to a more rational design of nanoparticle-based SERS substrates for sensing applications. MDPI 2023-05-09 /pmc/articles/PMC10216585/ /pubmed/37232891 http://dx.doi.org/10.3390/bios13050530 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Muntean, Cristina M.
Cuibus, Denisa
Boca, Sanda
Falamas, Alexandra
Tosa, Nicoleta
Brezeştean, Ioana Andreea
Bende, Attila
Barbu-Tudoran, Lucian
Moldovan, Rebeca
Bodoki, Ede
Farcǎu, Cosmin
Gold vs. Silver Colloidal Nanoparticle Films for Optimized SERS Detection of Propranolol and Electrochemical-SERS Analyses
title Gold vs. Silver Colloidal Nanoparticle Films for Optimized SERS Detection of Propranolol and Electrochemical-SERS Analyses
title_full Gold vs. Silver Colloidal Nanoparticle Films for Optimized SERS Detection of Propranolol and Electrochemical-SERS Analyses
title_fullStr Gold vs. Silver Colloidal Nanoparticle Films for Optimized SERS Detection of Propranolol and Electrochemical-SERS Analyses
title_full_unstemmed Gold vs. Silver Colloidal Nanoparticle Films for Optimized SERS Detection of Propranolol and Electrochemical-SERS Analyses
title_short Gold vs. Silver Colloidal Nanoparticle Films for Optimized SERS Detection of Propranolol and Electrochemical-SERS Analyses
title_sort gold vs. silver colloidal nanoparticle films for optimized sers detection of propranolol and electrochemical-sers analyses
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10216585/
https://www.ncbi.nlm.nih.gov/pubmed/37232891
http://dx.doi.org/10.3390/bios13050530
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