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Immunomodulatory Role of Vitamin D on Gut Microbiome in Children

Vitamin D plays a role in regulating the immune system and can be linked to the alteration of the gut microbiome, which leads to several immunological diseases. This systematic review aims to explore the relationship between Vitamin D and children’s gut microbiome, as well as its impact towards the...

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Autores principales: Tabassum, Anika, Ali, Adli, Zahedi, Farah Dayana, Ismail, Noor Akmal Shareela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10216599/
https://www.ncbi.nlm.nih.gov/pubmed/37239112
http://dx.doi.org/10.3390/biomedicines11051441
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author Tabassum, Anika
Ali, Adli
Zahedi, Farah Dayana
Ismail, Noor Akmal Shareela
author_facet Tabassum, Anika
Ali, Adli
Zahedi, Farah Dayana
Ismail, Noor Akmal Shareela
author_sort Tabassum, Anika
collection PubMed
description Vitamin D plays a role in regulating the immune system and can be linked to the alteration of the gut microbiome, which leads to several immunological diseases. This systematic review aims to explore the relationship between Vitamin D and children’s gut microbiome, as well as its impact towards the immune system. We have systematically collated relevant studies from different databases concerning changes in the gut microbiome of children from infants to 18 years old associated with Vitamin D and the immunological pathways. The studies utilized 16S rRNA sequencing analysis of fecal matter with or without Vitamin D supplementation and Vitamin D levels. Ten studies were selected for the review, among which eight studies showed significant alterations in the gut microbiome related to Vitamin D supplementation or Vitamin D levels. The taxa of the phylum Actinobacteria, Bacteroidetes, Firmicutes, and Proteobacteria are the most altered in these studies. The alteration of the taxa alters the Th1 and Th2 pathways and changes the immune response. We will discuss how Vitamin D may contribute to the activation of immune pathways via its effects on intestinal barrier function, microbiome composition, and/or direct effects on immune responses. In conclusion, the studies examined in this review have provided evidence that Vitamin D levels may have an impact on the composition of children’s gut microbiomes.
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spelling pubmed-102165992023-05-27 Immunomodulatory Role of Vitamin D on Gut Microbiome in Children Tabassum, Anika Ali, Adli Zahedi, Farah Dayana Ismail, Noor Akmal Shareela Biomedicines Systematic Review Vitamin D plays a role in regulating the immune system and can be linked to the alteration of the gut microbiome, which leads to several immunological diseases. This systematic review aims to explore the relationship between Vitamin D and children’s gut microbiome, as well as its impact towards the immune system. We have systematically collated relevant studies from different databases concerning changes in the gut microbiome of children from infants to 18 years old associated with Vitamin D and the immunological pathways. The studies utilized 16S rRNA sequencing analysis of fecal matter with or without Vitamin D supplementation and Vitamin D levels. Ten studies were selected for the review, among which eight studies showed significant alterations in the gut microbiome related to Vitamin D supplementation or Vitamin D levels. The taxa of the phylum Actinobacteria, Bacteroidetes, Firmicutes, and Proteobacteria are the most altered in these studies. The alteration of the taxa alters the Th1 and Th2 pathways and changes the immune response. We will discuss how Vitamin D may contribute to the activation of immune pathways via its effects on intestinal barrier function, microbiome composition, and/or direct effects on immune responses. In conclusion, the studies examined in this review have provided evidence that Vitamin D levels may have an impact on the composition of children’s gut microbiomes. MDPI 2023-05-14 /pmc/articles/PMC10216599/ /pubmed/37239112 http://dx.doi.org/10.3390/biomedicines11051441 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Systematic Review
Tabassum, Anika
Ali, Adli
Zahedi, Farah Dayana
Ismail, Noor Akmal Shareela
Immunomodulatory Role of Vitamin D on Gut Microbiome in Children
title Immunomodulatory Role of Vitamin D on Gut Microbiome in Children
title_full Immunomodulatory Role of Vitamin D on Gut Microbiome in Children
title_fullStr Immunomodulatory Role of Vitamin D on Gut Microbiome in Children
title_full_unstemmed Immunomodulatory Role of Vitamin D on Gut Microbiome in Children
title_short Immunomodulatory Role of Vitamin D on Gut Microbiome in Children
title_sort immunomodulatory role of vitamin d on gut microbiome in children
topic Systematic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10216599/
https://www.ncbi.nlm.nih.gov/pubmed/37239112
http://dx.doi.org/10.3390/biomedicines11051441
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