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Immunomodulatory Role of Vitamin D on Gut Microbiome in Children
Vitamin D plays a role in regulating the immune system and can be linked to the alteration of the gut microbiome, which leads to several immunological diseases. This systematic review aims to explore the relationship between Vitamin D and children’s gut microbiome, as well as its impact towards the...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10216599/ https://www.ncbi.nlm.nih.gov/pubmed/37239112 http://dx.doi.org/10.3390/biomedicines11051441 |
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author | Tabassum, Anika Ali, Adli Zahedi, Farah Dayana Ismail, Noor Akmal Shareela |
author_facet | Tabassum, Anika Ali, Adli Zahedi, Farah Dayana Ismail, Noor Akmal Shareela |
author_sort | Tabassum, Anika |
collection | PubMed |
description | Vitamin D plays a role in regulating the immune system and can be linked to the alteration of the gut microbiome, which leads to several immunological diseases. This systematic review aims to explore the relationship between Vitamin D and children’s gut microbiome, as well as its impact towards the immune system. We have systematically collated relevant studies from different databases concerning changes in the gut microbiome of children from infants to 18 years old associated with Vitamin D and the immunological pathways. The studies utilized 16S rRNA sequencing analysis of fecal matter with or without Vitamin D supplementation and Vitamin D levels. Ten studies were selected for the review, among which eight studies showed significant alterations in the gut microbiome related to Vitamin D supplementation or Vitamin D levels. The taxa of the phylum Actinobacteria, Bacteroidetes, Firmicutes, and Proteobacteria are the most altered in these studies. The alteration of the taxa alters the Th1 and Th2 pathways and changes the immune response. We will discuss how Vitamin D may contribute to the activation of immune pathways via its effects on intestinal barrier function, microbiome composition, and/or direct effects on immune responses. In conclusion, the studies examined in this review have provided evidence that Vitamin D levels may have an impact on the composition of children’s gut microbiomes. |
format | Online Article Text |
id | pubmed-10216599 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-102165992023-05-27 Immunomodulatory Role of Vitamin D on Gut Microbiome in Children Tabassum, Anika Ali, Adli Zahedi, Farah Dayana Ismail, Noor Akmal Shareela Biomedicines Systematic Review Vitamin D plays a role in regulating the immune system and can be linked to the alteration of the gut microbiome, which leads to several immunological diseases. This systematic review aims to explore the relationship between Vitamin D and children’s gut microbiome, as well as its impact towards the immune system. We have systematically collated relevant studies from different databases concerning changes in the gut microbiome of children from infants to 18 years old associated with Vitamin D and the immunological pathways. The studies utilized 16S rRNA sequencing analysis of fecal matter with or without Vitamin D supplementation and Vitamin D levels. Ten studies were selected for the review, among which eight studies showed significant alterations in the gut microbiome related to Vitamin D supplementation or Vitamin D levels. The taxa of the phylum Actinobacteria, Bacteroidetes, Firmicutes, and Proteobacteria are the most altered in these studies. The alteration of the taxa alters the Th1 and Th2 pathways and changes the immune response. We will discuss how Vitamin D may contribute to the activation of immune pathways via its effects on intestinal barrier function, microbiome composition, and/or direct effects on immune responses. In conclusion, the studies examined in this review have provided evidence that Vitamin D levels may have an impact on the composition of children’s gut microbiomes. MDPI 2023-05-14 /pmc/articles/PMC10216599/ /pubmed/37239112 http://dx.doi.org/10.3390/biomedicines11051441 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Systematic Review Tabassum, Anika Ali, Adli Zahedi, Farah Dayana Ismail, Noor Akmal Shareela Immunomodulatory Role of Vitamin D on Gut Microbiome in Children |
title | Immunomodulatory Role of Vitamin D on Gut Microbiome in Children |
title_full | Immunomodulatory Role of Vitamin D on Gut Microbiome in Children |
title_fullStr | Immunomodulatory Role of Vitamin D on Gut Microbiome in Children |
title_full_unstemmed | Immunomodulatory Role of Vitamin D on Gut Microbiome in Children |
title_short | Immunomodulatory Role of Vitamin D on Gut Microbiome in Children |
title_sort | immunomodulatory role of vitamin d on gut microbiome in children |
topic | Systematic Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10216599/ https://www.ncbi.nlm.nih.gov/pubmed/37239112 http://dx.doi.org/10.3390/biomedicines11051441 |
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