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Organokines in COVID-19: A Systematic Review
Coronavirus disease 2019 (COVID-19) is a viral infection caused by SARS-CoV-2 that induces a generalized inflammatory state. Organokines (adipokines, osteokines, myokines, hepatokines, and cardiokines) can produce beneficial or harmful effects in this condition. This study aimed to systematically re...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10216619/ https://www.ncbi.nlm.nih.gov/pubmed/37408184 http://dx.doi.org/10.3390/cells12101349 |
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author | Barbalho, Sandra Maria Minniti, Giulia Miola, Vitor Fernando Bordin Haber, Jesselina Francisco dos Santos Bueno, Patrícia Cincotto dos Santos de Argollo Haber, Luiza Santos Girio, Raul S. J. Detregiachi, Cláudia Rucco Penteado Dall’Antonia, Camila Tiveron Rodrigues, Victória Dogani Nicolau, Claudia C. T. Catharin, Virginia Maria Cavallari Strozze Araújo, Adriano Cressoni Laurindo, Lucas Fornari |
author_facet | Barbalho, Sandra Maria Minniti, Giulia Miola, Vitor Fernando Bordin Haber, Jesselina Francisco dos Santos Bueno, Patrícia Cincotto dos Santos de Argollo Haber, Luiza Santos Girio, Raul S. J. Detregiachi, Cláudia Rucco Penteado Dall’Antonia, Camila Tiveron Rodrigues, Victória Dogani Nicolau, Claudia C. T. Catharin, Virginia Maria Cavallari Strozze Araújo, Adriano Cressoni Laurindo, Lucas Fornari |
author_sort | Barbalho, Sandra Maria |
collection | PubMed |
description | Coronavirus disease 2019 (COVID-19) is a viral infection caused by SARS-CoV-2 that induces a generalized inflammatory state. Organokines (adipokines, osteokines, myokines, hepatokines, and cardiokines) can produce beneficial or harmful effects in this condition. This study aimed to systematically review the role of organokines on COVID-19. PubMed, Embase, Google Scholar, and Cochrane databases were searched, the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were followed, and 37 studies were selected, comprising more than 2700 individuals infected with the virus. Among COVID-19 patients, organokines have been associated with endothelial dysfunction and multiple organ failure due to augmented cytokines and increased SARS-CoV-2 viremia. Changes in the pattern of organokines secretion can directly or indirectly contribute to aggravating the infection, promoting immune response alterations, and predicting the disease progression. These molecules have the potential to be used as adjuvant biomarkers to predict the severity of the illness and severe outcomes. |
format | Online Article Text |
id | pubmed-10216619 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-102166192023-05-27 Organokines in COVID-19: A Systematic Review Barbalho, Sandra Maria Minniti, Giulia Miola, Vitor Fernando Bordin Haber, Jesselina Francisco dos Santos Bueno, Patrícia Cincotto dos Santos de Argollo Haber, Luiza Santos Girio, Raul S. J. Detregiachi, Cláudia Rucco Penteado Dall’Antonia, Camila Tiveron Rodrigues, Victória Dogani Nicolau, Claudia C. T. Catharin, Virginia Maria Cavallari Strozze Araújo, Adriano Cressoni Laurindo, Lucas Fornari Cells Systematic Review Coronavirus disease 2019 (COVID-19) is a viral infection caused by SARS-CoV-2 that induces a generalized inflammatory state. Organokines (adipokines, osteokines, myokines, hepatokines, and cardiokines) can produce beneficial or harmful effects in this condition. This study aimed to systematically review the role of organokines on COVID-19. PubMed, Embase, Google Scholar, and Cochrane databases were searched, the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were followed, and 37 studies were selected, comprising more than 2700 individuals infected with the virus. Among COVID-19 patients, organokines have been associated with endothelial dysfunction and multiple organ failure due to augmented cytokines and increased SARS-CoV-2 viremia. Changes in the pattern of organokines secretion can directly or indirectly contribute to aggravating the infection, promoting immune response alterations, and predicting the disease progression. These molecules have the potential to be used as adjuvant biomarkers to predict the severity of the illness and severe outcomes. MDPI 2023-05-09 /pmc/articles/PMC10216619/ /pubmed/37408184 http://dx.doi.org/10.3390/cells12101349 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Systematic Review Barbalho, Sandra Maria Minniti, Giulia Miola, Vitor Fernando Bordin Haber, Jesselina Francisco dos Santos Bueno, Patrícia Cincotto dos Santos de Argollo Haber, Luiza Santos Girio, Raul S. J. Detregiachi, Cláudia Rucco Penteado Dall’Antonia, Camila Tiveron Rodrigues, Victória Dogani Nicolau, Claudia C. T. Catharin, Virginia Maria Cavallari Strozze Araújo, Adriano Cressoni Laurindo, Lucas Fornari Organokines in COVID-19: A Systematic Review |
title | Organokines in COVID-19: A Systematic Review |
title_full | Organokines in COVID-19: A Systematic Review |
title_fullStr | Organokines in COVID-19: A Systematic Review |
title_full_unstemmed | Organokines in COVID-19: A Systematic Review |
title_short | Organokines in COVID-19: A Systematic Review |
title_sort | organokines in covid-19: a systematic review |
topic | Systematic Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10216619/ https://www.ncbi.nlm.nih.gov/pubmed/37408184 http://dx.doi.org/10.3390/cells12101349 |
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