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Prevention of Neurological Sequelae in Preterm Infants

Background: Preterm birth is one of the world’s critical health problems, with an incidence of 5% to 18% of living newborns according to various countries. White matter injuries due to preoligodendrocytes deficits cause hypomyelination in children born preterm. Preterm infants also have multiple neu...

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Autores principales: Gonzalez-Moreira, Eduardo, Harmony, Thalía, Hinojosa-Rodríguez, Manuel, Carrillo-Prado, Cristina, Juárez-Colín, María Elena, Gutiérrez-Hernández, Claudia Calipso, Carlier, María Elizabeth Mónica, Cubero-Rego, Lourdes, Castro-Chavira, Susana A., Fernández, Thalía
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10216630/
https://www.ncbi.nlm.nih.gov/pubmed/37239225
http://dx.doi.org/10.3390/brainsci13050753
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author Gonzalez-Moreira, Eduardo
Harmony, Thalía
Hinojosa-Rodríguez, Manuel
Carrillo-Prado, Cristina
Juárez-Colín, María Elena
Gutiérrez-Hernández, Claudia Calipso
Carlier, María Elizabeth Mónica
Cubero-Rego, Lourdes
Castro-Chavira, Susana A.
Fernández, Thalía
author_facet Gonzalez-Moreira, Eduardo
Harmony, Thalía
Hinojosa-Rodríguez, Manuel
Carrillo-Prado, Cristina
Juárez-Colín, María Elena
Gutiérrez-Hernández, Claudia Calipso
Carlier, María Elizabeth Mónica
Cubero-Rego, Lourdes
Castro-Chavira, Susana A.
Fernández, Thalía
author_sort Gonzalez-Moreira, Eduardo
collection PubMed
description Background: Preterm birth is one of the world’s critical health problems, with an incidence of 5% to 18% of living newborns according to various countries. White matter injuries due to preoligodendrocytes deficits cause hypomyelination in children born preterm. Preterm infants also have multiple neurodevelopmental sequelae due to prenatal and perinatal risk factors for brain damage. The purpose of this work was to explore the effects of the brain risk factors and MRI volumes and abnormalities on the posterior motor and cognitive development at 3 years of age. Methods: A total of 166 preterm infants were examined before 4 months and clinical and MRI evaluations were performed. MRI showed abnormal findings in 89% of the infants. Parents of all infants were invited to receive the Katona neurohabilitation treatment. The parents of 128 infants accepted and received Katona’s neurohabilitation treatment. The remaining 38 infants did not receive treatment for a variety of reasons. At the three-year follow-up, Bayley’s II Mental Developmental Index (MDI) and the Psychomotor Developmental Index (PDI) were compared between treated and untreated subjects. Results: The treated children had higher values of both indices than the untreated. Linear regression showed that the antecedents of placenta disorders and sepsis as well as volumes of the corpus callosum and of the left lateral ventricle significantly predicted both MDI and PDI, while Apgar < 7 and volume of the right lateral ventricle predicted the PDI. Conclusions: (1) The results indicate that preterm infants who received Katona’s neurohabilitation procedure exhibited significantly better outcomes at 3 years of age compared to those who did not receive the treatment. (2) The presence of sepsis and the volumes of the corpus callosum and lateral ventricles at 3–4 months were significant predictors of the outcome at 3 years of age.
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spelling pubmed-102166302023-05-27 Prevention of Neurological Sequelae in Preterm Infants Gonzalez-Moreira, Eduardo Harmony, Thalía Hinojosa-Rodríguez, Manuel Carrillo-Prado, Cristina Juárez-Colín, María Elena Gutiérrez-Hernández, Claudia Calipso Carlier, María Elizabeth Mónica Cubero-Rego, Lourdes Castro-Chavira, Susana A. Fernández, Thalía Brain Sci Article Background: Preterm birth is one of the world’s critical health problems, with an incidence of 5% to 18% of living newborns according to various countries. White matter injuries due to preoligodendrocytes deficits cause hypomyelination in children born preterm. Preterm infants also have multiple neurodevelopmental sequelae due to prenatal and perinatal risk factors for brain damage. The purpose of this work was to explore the effects of the brain risk factors and MRI volumes and abnormalities on the posterior motor and cognitive development at 3 years of age. Methods: A total of 166 preterm infants were examined before 4 months and clinical and MRI evaluations were performed. MRI showed abnormal findings in 89% of the infants. Parents of all infants were invited to receive the Katona neurohabilitation treatment. The parents of 128 infants accepted and received Katona’s neurohabilitation treatment. The remaining 38 infants did not receive treatment for a variety of reasons. At the three-year follow-up, Bayley’s II Mental Developmental Index (MDI) and the Psychomotor Developmental Index (PDI) were compared between treated and untreated subjects. Results: The treated children had higher values of both indices than the untreated. Linear regression showed that the antecedents of placenta disorders and sepsis as well as volumes of the corpus callosum and of the left lateral ventricle significantly predicted both MDI and PDI, while Apgar < 7 and volume of the right lateral ventricle predicted the PDI. Conclusions: (1) The results indicate that preterm infants who received Katona’s neurohabilitation procedure exhibited significantly better outcomes at 3 years of age compared to those who did not receive the treatment. (2) The presence of sepsis and the volumes of the corpus callosum and lateral ventricles at 3–4 months were significant predictors of the outcome at 3 years of age. MDPI 2023-05-02 /pmc/articles/PMC10216630/ /pubmed/37239225 http://dx.doi.org/10.3390/brainsci13050753 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Gonzalez-Moreira, Eduardo
Harmony, Thalía
Hinojosa-Rodríguez, Manuel
Carrillo-Prado, Cristina
Juárez-Colín, María Elena
Gutiérrez-Hernández, Claudia Calipso
Carlier, María Elizabeth Mónica
Cubero-Rego, Lourdes
Castro-Chavira, Susana A.
Fernández, Thalía
Prevention of Neurological Sequelae in Preterm Infants
title Prevention of Neurological Sequelae in Preterm Infants
title_full Prevention of Neurological Sequelae in Preterm Infants
title_fullStr Prevention of Neurological Sequelae in Preterm Infants
title_full_unstemmed Prevention of Neurological Sequelae in Preterm Infants
title_short Prevention of Neurological Sequelae in Preterm Infants
title_sort prevention of neurological sequelae in preterm infants
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10216630/
https://www.ncbi.nlm.nih.gov/pubmed/37239225
http://dx.doi.org/10.3390/brainsci13050753
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