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Glycine-β-Muricholic Acid Improves Liver Fibrosis and Gut Barrier Function by Reducing Bile Acid Pool Size and Hydrophobicity in Male Cyp2c70 Knockout Mice

Cyp2c70 knockout mice lack the enzyme that produces muricholic acids and show a “human-like” hydrophobic bile acid pool-induced hepatobiliary injury. In this study, we investigated the potential anti-cholestasis effect of glycine-conjugated β muricholic acid (G-β-MCA) in male Cyp2c70 KO mice based o...

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Detalles Bibliográficos
Autores principales:	Hasan, Mohammad Nazmul, Chen, Jianglei, Wang, Huaiwen, Du, Yanhong, Clayton, Yung Dai, Gu, Lijie, Li, Tiangang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10216635/ https://www.ncbi.nlm.nih.gov/pubmed/37408204 http://dx.doi.org/10.3390/cells12101371

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