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Viral Coinfection of Children Hospitalized with Severe Acute Respiratory Infections during COVID-19 Pandemic

The main pathogens of severe respiratory infection in children are respiratory viruses, and the current molecular technology allows for a rapid and simultaneous detection of a wide spectrum of these viral pathogens, facilitating the diagnosis and evaluation of viral coinfection. Methods: This study...

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Autores principales: Malveste Ito, Célia Regina, Moreira, André Luís Elias, da Silva, Paulo Alex Neves, Santos, Mônica de Oliveira, dos Santos, Adailton Pereira, Rézio, Geovana Sôffa, de Brito, Pollyanna Neta, Rezende, Alana Parreira Costa, Fonseca, Jakeline Godinho, Peixoto, Fernanda Aparecida de Oliveira, Wastowski, Isabela Jubé, Goes, Viviane Monteiro, Estrela, Mariely Cordeiro, de Souza, Priscila Zanette, Carneiro, Lilian Carla, Avelino, Melissa Ameloti Gomes
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10216660/
https://www.ncbi.nlm.nih.gov/pubmed/37239073
http://dx.doi.org/10.3390/biomedicines11051402
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author Malveste Ito, Célia Regina
Moreira, André Luís Elias
da Silva, Paulo Alex Neves
Santos, Mônica de Oliveira
dos Santos, Adailton Pereira
Rézio, Geovana Sôffa
de Brito, Pollyanna Neta
Rezende, Alana Parreira Costa
Fonseca, Jakeline Godinho
Peixoto, Fernanda Aparecida de Oliveira
Wastowski, Isabela Jubé
Goes, Viviane Monteiro
Estrela, Mariely Cordeiro
de Souza, Priscila Zanette
Carneiro, Lilian Carla
Avelino, Melissa Ameloti Gomes
author_facet Malveste Ito, Célia Regina
Moreira, André Luís Elias
da Silva, Paulo Alex Neves
Santos, Mônica de Oliveira
dos Santos, Adailton Pereira
Rézio, Geovana Sôffa
de Brito, Pollyanna Neta
Rezende, Alana Parreira Costa
Fonseca, Jakeline Godinho
Peixoto, Fernanda Aparecida de Oliveira
Wastowski, Isabela Jubé
Goes, Viviane Monteiro
Estrela, Mariely Cordeiro
de Souza, Priscila Zanette
Carneiro, Lilian Carla
Avelino, Melissa Ameloti Gomes
author_sort Malveste Ito, Célia Regina
collection PubMed
description The main pathogens of severe respiratory infection in children are respiratory viruses, and the current molecular technology allows for a rapid and simultaneous detection of a wide spectrum of these viral pathogens, facilitating the diagnosis and evaluation of viral coinfection. Methods: This study was conducted between March 2020 and December 2021. All children admitted to the ICU with a diagnosis of SARI and who were tested by polymerase chain reaction on nasopharyngeal swabs for SARS-CoV-2 and other common respiratory viral pathogens were included in the study. Results: The result of the viral panel identified 446 children, with one infected with a single virus and 160 co-infected with two or more viruses. This study employed descriptive analyses, where a total of twenty-two coinfections among SARI-causing viruses were identified. Thus, the five most frequent coinfections that were selected for the study are: hRV/SARS-CoV-2 (17.91%), hRV/RSV (14.18%), RSV/SARS-CoV-2 (12.69%), hRV/BoV (10.45%), and hRV/AdV (8.21%). The most significant age group was 38.1%, representing patients aged between 24 and 59 months (61 individuals). Patients older than 59 months represented a total of 27.5%, comprising forty-four patients. The use of oxygen therapy was statistically significant in coinfections with Bocavirus, other CoVs, Metapneumovirus, and RSV. Coinfections with SARS-CoV-2 and the other different coinfections presented a similar time of use of oxygen therapy with a value of (p > 0.05). In the year 2020, hRV/BoV was more frequent in relation to other types of coinfections, representing a total of 35.1%. The year 2021 presented a divergent profile, with hRV/SARS-CoV-2 coinfection being the most frequent (30.8%), followed by hRV/RSV (28.2%). Additionally, 25.6% and 15.4% represented coinfections between RSV/SARS-CoV-2 and hRV/AdV, respectively. We saw that two of the patients coinfected with hRV/SARS-CoV-2 died, representing 9.52% of all deaths in the study. In addition, both hRV/hBoV and hRV/RSV had death records for each case, representing 8.33% and 6.67% of all deaths, respectively. Conclusion: Coinfections with respiratory viruses, such as RSV and hBoV, can increase the severity of the disease in children with SARI who are admitted to the ICU, and children infected with SARS-CoV-2 have their clinical condition worsened when they have comorbidities.
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spelling pubmed-102166602023-05-27 Viral Coinfection of Children Hospitalized with Severe Acute Respiratory Infections during COVID-19 Pandemic Malveste Ito, Célia Regina Moreira, André Luís Elias da Silva, Paulo Alex Neves Santos, Mônica de Oliveira dos Santos, Adailton Pereira Rézio, Geovana Sôffa de Brito, Pollyanna Neta Rezende, Alana Parreira Costa Fonseca, Jakeline Godinho Peixoto, Fernanda Aparecida de Oliveira Wastowski, Isabela Jubé Goes, Viviane Monteiro Estrela, Mariely Cordeiro de Souza, Priscila Zanette Carneiro, Lilian Carla Avelino, Melissa Ameloti Gomes Biomedicines Article The main pathogens of severe respiratory infection in children are respiratory viruses, and the current molecular technology allows for a rapid and simultaneous detection of a wide spectrum of these viral pathogens, facilitating the diagnosis and evaluation of viral coinfection. Methods: This study was conducted between March 2020 and December 2021. All children admitted to the ICU with a diagnosis of SARI and who were tested by polymerase chain reaction on nasopharyngeal swabs for SARS-CoV-2 and other common respiratory viral pathogens were included in the study. Results: The result of the viral panel identified 446 children, with one infected with a single virus and 160 co-infected with two or more viruses. This study employed descriptive analyses, where a total of twenty-two coinfections among SARI-causing viruses were identified. Thus, the five most frequent coinfections that were selected for the study are: hRV/SARS-CoV-2 (17.91%), hRV/RSV (14.18%), RSV/SARS-CoV-2 (12.69%), hRV/BoV (10.45%), and hRV/AdV (8.21%). The most significant age group was 38.1%, representing patients aged between 24 and 59 months (61 individuals). Patients older than 59 months represented a total of 27.5%, comprising forty-four patients. The use of oxygen therapy was statistically significant in coinfections with Bocavirus, other CoVs, Metapneumovirus, and RSV. Coinfections with SARS-CoV-2 and the other different coinfections presented a similar time of use of oxygen therapy with a value of (p > 0.05). In the year 2020, hRV/BoV was more frequent in relation to other types of coinfections, representing a total of 35.1%. The year 2021 presented a divergent profile, with hRV/SARS-CoV-2 coinfection being the most frequent (30.8%), followed by hRV/RSV (28.2%). Additionally, 25.6% and 15.4% represented coinfections between RSV/SARS-CoV-2 and hRV/AdV, respectively. We saw that two of the patients coinfected with hRV/SARS-CoV-2 died, representing 9.52% of all deaths in the study. In addition, both hRV/hBoV and hRV/RSV had death records for each case, representing 8.33% and 6.67% of all deaths, respectively. Conclusion: Coinfections with respiratory viruses, such as RSV and hBoV, can increase the severity of the disease in children with SARI who are admitted to the ICU, and children infected with SARS-CoV-2 have their clinical condition worsened when they have comorbidities. MDPI 2023-05-09 /pmc/articles/PMC10216660/ /pubmed/37239073 http://dx.doi.org/10.3390/biomedicines11051402 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Malveste Ito, Célia Regina
Moreira, André Luís Elias
da Silva, Paulo Alex Neves
Santos, Mônica de Oliveira
dos Santos, Adailton Pereira
Rézio, Geovana Sôffa
de Brito, Pollyanna Neta
Rezende, Alana Parreira Costa
Fonseca, Jakeline Godinho
Peixoto, Fernanda Aparecida de Oliveira
Wastowski, Isabela Jubé
Goes, Viviane Monteiro
Estrela, Mariely Cordeiro
de Souza, Priscila Zanette
Carneiro, Lilian Carla
Avelino, Melissa Ameloti Gomes
Viral Coinfection of Children Hospitalized with Severe Acute Respiratory Infections during COVID-19 Pandemic
title Viral Coinfection of Children Hospitalized with Severe Acute Respiratory Infections during COVID-19 Pandemic
title_full Viral Coinfection of Children Hospitalized with Severe Acute Respiratory Infections during COVID-19 Pandemic
title_fullStr Viral Coinfection of Children Hospitalized with Severe Acute Respiratory Infections during COVID-19 Pandemic
title_full_unstemmed Viral Coinfection of Children Hospitalized with Severe Acute Respiratory Infections during COVID-19 Pandemic
title_short Viral Coinfection of Children Hospitalized with Severe Acute Respiratory Infections during COVID-19 Pandemic
title_sort viral coinfection of children hospitalized with severe acute respiratory infections during covid-19 pandemic
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10216660/
https://www.ncbi.nlm.nih.gov/pubmed/37239073
http://dx.doi.org/10.3390/biomedicines11051402
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