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Epidural Injection Method for Long-Term Pain Management in Rats with Spinal Stenosis

Epidural injection is one of the most common nonsurgical treatment options for long-term pain relief in lumbar spinal stenosis. Recently, various nerve block injections have been used for pain management. Among them, nerve block through epidural injection is a safe and effective method for the clini...

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Autores principales: Hong, Jin Young, Kim, Hyunseong, Lee, Junseon, Jeon, Wan-Jin, Yeo, Changhwan, Kim, Hyun, Lee, Yoon Jae, Ha, In-Hyuk
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10216675/
https://www.ncbi.nlm.nih.gov/pubmed/37239061
http://dx.doi.org/10.3390/biomedicines11051390
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author Hong, Jin Young
Kim, Hyunseong
Lee, Junseon
Jeon, Wan-Jin
Yeo, Changhwan
Kim, Hyun
Lee, Yoon Jae
Ha, In-Hyuk
author_facet Hong, Jin Young
Kim, Hyunseong
Lee, Junseon
Jeon, Wan-Jin
Yeo, Changhwan
Kim, Hyun
Lee, Yoon Jae
Ha, In-Hyuk
author_sort Hong, Jin Young
collection PubMed
description Epidural injection is one of the most common nonsurgical treatment options for long-term pain relief in lumbar spinal stenosis. Recently, various nerve block injections have been used for pain management. Among them, nerve block through epidural injection is a safe and effective method for the clinical treatment of low back or lower extremity pain. Although the epidural injection method has a long history, the effectiveness of long-term epidural injections in disc diseases has not been scientifically proven. In particular, to verify the safety and efficacy of drugs in preclinical studies, the route and method of drug administration in terms of the clinical application method and duration of use must be established. However, there is no standardized method for long-term epidural injections in a rat model of stenosis to identify the precise efficacy and safety of epidural injections. Therefore, standardizing the epidural injection method is very important for evaluating the efficacy and safety of drugs used for back or lower extremity pain. We describe the first standardized long-term epidural injection method for evaluating the efficacy and safety of drugs according to their route of administration in rats with lumbar spinal stenosis.
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spelling pubmed-102166752023-05-27 Epidural Injection Method for Long-Term Pain Management in Rats with Spinal Stenosis Hong, Jin Young Kim, Hyunseong Lee, Junseon Jeon, Wan-Jin Yeo, Changhwan Kim, Hyun Lee, Yoon Jae Ha, In-Hyuk Biomedicines Article Epidural injection is one of the most common nonsurgical treatment options for long-term pain relief in lumbar spinal stenosis. Recently, various nerve block injections have been used for pain management. Among them, nerve block through epidural injection is a safe and effective method for the clinical treatment of low back or lower extremity pain. Although the epidural injection method has a long history, the effectiveness of long-term epidural injections in disc diseases has not been scientifically proven. In particular, to verify the safety and efficacy of drugs in preclinical studies, the route and method of drug administration in terms of the clinical application method and duration of use must be established. However, there is no standardized method for long-term epidural injections in a rat model of stenosis to identify the precise efficacy and safety of epidural injections. Therefore, standardizing the epidural injection method is very important for evaluating the efficacy and safety of drugs used for back or lower extremity pain. We describe the first standardized long-term epidural injection method for evaluating the efficacy and safety of drugs according to their route of administration in rats with lumbar spinal stenosis. MDPI 2023-05-08 /pmc/articles/PMC10216675/ /pubmed/37239061 http://dx.doi.org/10.3390/biomedicines11051390 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Hong, Jin Young
Kim, Hyunseong
Lee, Junseon
Jeon, Wan-Jin
Yeo, Changhwan
Kim, Hyun
Lee, Yoon Jae
Ha, In-Hyuk
Epidural Injection Method for Long-Term Pain Management in Rats with Spinal Stenosis
title Epidural Injection Method for Long-Term Pain Management in Rats with Spinal Stenosis
title_full Epidural Injection Method for Long-Term Pain Management in Rats with Spinal Stenosis
title_fullStr Epidural Injection Method for Long-Term Pain Management in Rats with Spinal Stenosis
title_full_unstemmed Epidural Injection Method for Long-Term Pain Management in Rats with Spinal Stenosis
title_short Epidural Injection Method for Long-Term Pain Management in Rats with Spinal Stenosis
title_sort epidural injection method for long-term pain management in rats with spinal stenosis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10216675/
https://www.ncbi.nlm.nih.gov/pubmed/37239061
http://dx.doi.org/10.3390/biomedicines11051390
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