TIGIT Expression on Activated NK Cells Correlates with Greater Anti-Tumor Activity but Promotes Functional Decline upon Lung Cancer Exposure: Implications for Adoptive Cell Therapy and TIGIT-Targeted Therapies

SIMPLE SUMMARY: Therapies targeting TIGIT have garnered tremendous interest, but have so far failed to reach primary endpoints in PhIII trials in lung cancer settings. This study examined the function of TIGIT on NK cells and how NK cells may impact the success of TIGIT therapeutics. This study demo...

Descripción completa

Detalles Bibliográficos
Autores principales: Hasan, Md Faqrul, Croom-Perez, Tayler J., Oyer, Jeremiah L., Dieffenthaller, Thomas A., Robles-Carrillo, Liza D., Eloriaga, Jonathan E., Kumar, Sanjana, Andersen, Brendan W., Copik, Alicja J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10216728/
https://www.ncbi.nlm.nih.gov/pubmed/37345049
http://dx.doi.org/10.3390/cancers15102712

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10216728/
https://www.ncbi.nlm.nih.gov/pubmed/37345049
http://dx.doi.org/10.3390/cancers15102712

Ejemplares similares