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Genetically Engineered Triple MAPT-Mutant Human-Induced Pluripotent Stem Cells (N279K, P301L, and E10+16 Mutations) Exhibit Impairments in Mitochondrial Bioenergetics and Dynamics

Pathological abnormalities in the tau protein give rise to a variety of neurodegenerative diseases, conjointly termed tauopathies. Several tau mutations have been identified in the tau-encoding gene MAPT, affecting either the physical properties of tau or resulting in altered tau splicing. At early...

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Detalles Bibliográficos
Autores principales:	Szabo, Leonora, Grimm, Amandine, García-León, Juan Antonio, Verfaillie, Catherine M., Eckert, Anne
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10216799/ https://www.ncbi.nlm.nih.gov/pubmed/37408218 http://dx.doi.org/10.3390/cells12101385

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