Mitochondrial Dysfunction and Impaired Antioxidant Responses in Retinal Pigment Epithelial Cells Derived from a Patient with RCBTB1-Associated Retinopathy

Mutations in the RCBTB1 gene cause inherited retinal disease; however, the pathogenic mechanisms associated with RCBTB1 deficiency remain poorly understood. Here, we investigated the effect of RCBTB1 deficiency on mitochondria and oxidative stress responses in induced pluripotent stem cell (iPSC)-de...

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Detalles Bibliográficos
Autores principales: Huang, Zhiqin, Zhang, Dan, Chen, Shang-Chih, Huang, Di, Mackey, David, Chen, Fred K., McLenachan, Samuel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10216830/
https://www.ncbi.nlm.nih.gov/pubmed/37408192
http://dx.doi.org/10.3390/cells12101358

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