Cargando…
Vibegron 50 mg Once Daily Improves OABSS, OAB-q SF Score in OAB Patients ≥80 Years Old in Real-World Clinical Settings and Switching from Other OAB Drugs May Reduce Residual Urine Volume
OBJECTIVE: The treatment effects of vibegron have not previously been evaluated in a prospective, non-interventional observational study of elderly Japanese patients, particularly those ≥80 years old. In addition, no reports have referred to residual urine volume in switching cases. We therefore gro...
Autores principales: | , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10216872/ https://www.ncbi.nlm.nih.gov/pubmed/37251707 http://dx.doi.org/10.2147/RRU.S411841 |
_version_ | 1785048402512314368 |
---|---|
author | Kuno, Takahira Tamura, Kenji Shimizu, Nobutaka Fukuhara, Hideo Fukata, Satoshi Ashida, Shingo Karashima, Takashi Satake, Hirofumi Sawada, Kohji Yamasaki, Ichiro Komatsu, Fumito Kuroiwa, Hajime Saito, Motoaki Inoue, Keiji |
author_facet | Kuno, Takahira Tamura, Kenji Shimizu, Nobutaka Fukuhara, Hideo Fukata, Satoshi Ashida, Shingo Karashima, Takashi Satake, Hirofumi Sawada, Kohji Yamasaki, Ichiro Komatsu, Fumito Kuroiwa, Hajime Saito, Motoaki Inoue, Keiji |
author_sort | Kuno, Takahira |
collection | PubMed |
description | OBJECTIVE: The treatment effects of vibegron have not previously been evaluated in a prospective, non-interventional observational study of elderly Japanese patients, particularly those ≥80 years old. In addition, no reports have referred to residual urine volume in switching cases. We therefore grouped patients by condition and investigated the treatment effects of vibegron on Overactive Bladder Symptom Score (OABSS), Overactive Bladder Questionnaire Short Form (OAB-q SF), and residual urine volume in each group. METHODS: This multicenter, prospective, non-interventional, observational study consecutively enrolled OAB patients with total OABSS score ≥3 and OABSS question 3 score ≥2. Sixty-three patients from six centers were recruited. Vibegron 50 mg once daily was administered for 12 weeks as first-line monotherapy (first-line group), monotherapy switching from antimuscarinics or mirabegron due to failure of prior therapy (no washout period), or combination therapy with antimuscarinics (second-line group). OABSS, OAB-q SF, and residual urine volume were collected after 4 and 12 weeks. Adverse events were also recorded at each visit. RESULTS: Of the 63 patients registered, 61 were eligible for analysis (first line, n=36; second line, n=25). The OABSS, excluding daytime frequency scores, and OAB-q SF scale showed significant improvement in all conditions. Switching from mirabegron to vibegron significantly reduced residual urine volume. No serious treatment-related adverse events were encountered. CONCLUSION: Vibegron 50 mg once daily significantly improved OABSS and OAB-q SF even in patients ≥80 years old. Notably, switching from mirabegron to vibegron resulted in significant improvements to residual urine volume. |
format | Online Article Text |
id | pubmed-10216872 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Dove |
record_format | MEDLINE/PubMed |
spelling | pubmed-102168722023-05-27 Vibegron 50 mg Once Daily Improves OABSS, OAB-q SF Score in OAB Patients ≥80 Years Old in Real-World Clinical Settings and Switching from Other OAB Drugs May Reduce Residual Urine Volume Kuno, Takahira Tamura, Kenji Shimizu, Nobutaka Fukuhara, Hideo Fukata, Satoshi Ashida, Shingo Karashima, Takashi Satake, Hirofumi Sawada, Kohji Yamasaki, Ichiro Komatsu, Fumito Kuroiwa, Hajime Saito, Motoaki Inoue, Keiji Res Rep Urol Original Research OBJECTIVE: The treatment effects of vibegron have not previously been evaluated in a prospective, non-interventional observational study of elderly Japanese patients, particularly those ≥80 years old. In addition, no reports have referred to residual urine volume in switching cases. We therefore grouped patients by condition and investigated the treatment effects of vibegron on Overactive Bladder Symptom Score (OABSS), Overactive Bladder Questionnaire Short Form (OAB-q SF), and residual urine volume in each group. METHODS: This multicenter, prospective, non-interventional, observational study consecutively enrolled OAB patients with total OABSS score ≥3 and OABSS question 3 score ≥2. Sixty-three patients from six centers were recruited. Vibegron 50 mg once daily was administered for 12 weeks as first-line monotherapy (first-line group), monotherapy switching from antimuscarinics or mirabegron due to failure of prior therapy (no washout period), or combination therapy with antimuscarinics (second-line group). OABSS, OAB-q SF, and residual urine volume were collected after 4 and 12 weeks. Adverse events were also recorded at each visit. RESULTS: Of the 63 patients registered, 61 were eligible for analysis (first line, n=36; second line, n=25). The OABSS, excluding daytime frequency scores, and OAB-q SF scale showed significant improvement in all conditions. Switching from mirabegron to vibegron significantly reduced residual urine volume. No serious treatment-related adverse events were encountered. CONCLUSION: Vibegron 50 mg once daily significantly improved OABSS and OAB-q SF even in patients ≥80 years old. Notably, switching from mirabegron to vibegron resulted in significant improvements to residual urine volume. Dove 2023-05-22 /pmc/articles/PMC10216872/ /pubmed/37251707 http://dx.doi.org/10.2147/RRU.S411841 Text en © 2023 Kuno et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php). |
spellingShingle | Original Research Kuno, Takahira Tamura, Kenji Shimizu, Nobutaka Fukuhara, Hideo Fukata, Satoshi Ashida, Shingo Karashima, Takashi Satake, Hirofumi Sawada, Kohji Yamasaki, Ichiro Komatsu, Fumito Kuroiwa, Hajime Saito, Motoaki Inoue, Keiji Vibegron 50 mg Once Daily Improves OABSS, OAB-q SF Score in OAB Patients ≥80 Years Old in Real-World Clinical Settings and Switching from Other OAB Drugs May Reduce Residual Urine Volume |
title | Vibegron 50 mg Once Daily Improves OABSS, OAB-q SF Score in OAB Patients ≥80 Years Old in Real-World Clinical Settings and Switching from Other OAB Drugs May Reduce Residual Urine Volume |
title_full | Vibegron 50 mg Once Daily Improves OABSS, OAB-q SF Score in OAB Patients ≥80 Years Old in Real-World Clinical Settings and Switching from Other OAB Drugs May Reduce Residual Urine Volume |
title_fullStr | Vibegron 50 mg Once Daily Improves OABSS, OAB-q SF Score in OAB Patients ≥80 Years Old in Real-World Clinical Settings and Switching from Other OAB Drugs May Reduce Residual Urine Volume |
title_full_unstemmed | Vibegron 50 mg Once Daily Improves OABSS, OAB-q SF Score in OAB Patients ≥80 Years Old in Real-World Clinical Settings and Switching from Other OAB Drugs May Reduce Residual Urine Volume |
title_short | Vibegron 50 mg Once Daily Improves OABSS, OAB-q SF Score in OAB Patients ≥80 Years Old in Real-World Clinical Settings and Switching from Other OAB Drugs May Reduce Residual Urine Volume |
title_sort | vibegron 50 mg once daily improves oabss, oab-q sf score in oab patients ≥80 years old in real-world clinical settings and switching from other oab drugs may reduce residual urine volume |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10216872/ https://www.ncbi.nlm.nih.gov/pubmed/37251707 http://dx.doi.org/10.2147/RRU.S411841 |
work_keys_str_mv | AT kunotakahira vibegron50mgoncedailyimprovesoabssoabqsfscoreinoabpatients80yearsoldinrealworldclinicalsettingsandswitchingfromotheroabdrugsmayreduceresidualurinevolume AT tamurakenji vibegron50mgoncedailyimprovesoabssoabqsfscoreinoabpatients80yearsoldinrealworldclinicalsettingsandswitchingfromotheroabdrugsmayreduceresidualurinevolume AT shimizunobutaka vibegron50mgoncedailyimprovesoabssoabqsfscoreinoabpatients80yearsoldinrealworldclinicalsettingsandswitchingfromotheroabdrugsmayreduceresidualurinevolume AT fukuharahideo vibegron50mgoncedailyimprovesoabssoabqsfscoreinoabpatients80yearsoldinrealworldclinicalsettingsandswitchingfromotheroabdrugsmayreduceresidualurinevolume AT fukatasatoshi vibegron50mgoncedailyimprovesoabssoabqsfscoreinoabpatients80yearsoldinrealworldclinicalsettingsandswitchingfromotheroabdrugsmayreduceresidualurinevolume AT ashidashingo vibegron50mgoncedailyimprovesoabssoabqsfscoreinoabpatients80yearsoldinrealworldclinicalsettingsandswitchingfromotheroabdrugsmayreduceresidualurinevolume AT karashimatakashi vibegron50mgoncedailyimprovesoabssoabqsfscoreinoabpatients80yearsoldinrealworldclinicalsettingsandswitchingfromotheroabdrugsmayreduceresidualurinevolume AT satakehirofumi vibegron50mgoncedailyimprovesoabssoabqsfscoreinoabpatients80yearsoldinrealworldclinicalsettingsandswitchingfromotheroabdrugsmayreduceresidualurinevolume AT sawadakohji vibegron50mgoncedailyimprovesoabssoabqsfscoreinoabpatients80yearsoldinrealworldclinicalsettingsandswitchingfromotheroabdrugsmayreduceresidualurinevolume AT yamasakiichiro vibegron50mgoncedailyimprovesoabssoabqsfscoreinoabpatients80yearsoldinrealworldclinicalsettingsandswitchingfromotheroabdrugsmayreduceresidualurinevolume AT komatsufumito vibegron50mgoncedailyimprovesoabssoabqsfscoreinoabpatients80yearsoldinrealworldclinicalsettingsandswitchingfromotheroabdrugsmayreduceresidualurinevolume AT kuroiwahajime vibegron50mgoncedailyimprovesoabssoabqsfscoreinoabpatients80yearsoldinrealworldclinicalsettingsandswitchingfromotheroabdrugsmayreduceresidualurinevolume AT saitomotoaki vibegron50mgoncedailyimprovesoabssoabqsfscoreinoabpatients80yearsoldinrealworldclinicalsettingsandswitchingfromotheroabdrugsmayreduceresidualurinevolume AT inouekeiji vibegron50mgoncedailyimprovesoabssoabqsfscoreinoabpatients80yearsoldinrealworldclinicalsettingsandswitchingfromotheroabdrugsmayreduceresidualurinevolume |