Cargando…

Short- and Long-Term Outcomes of Preeclampsia in Offspring: Review of the Literature

Preeclampsia is a multisystemic clinical syndrome characterized by the appearance of new-onset hypertension and proteinuria or hypertension and end organ dysfunction even without proteinuria after 20 weeks of pregnancy or postpartum. Residing at the severe end of the spectrum of the hypertensive dis...

Descripción completa

Detalles Bibliográficos
Autores principales: Koulouraki, Sevasti, Paschos, Vasileios, Pervanidou, Panagiota, Christopoulos, Panagiotis, Gerede, Angeliki, Eleftheriades, Makarios
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10216976/
https://www.ncbi.nlm.nih.gov/pubmed/37238374
http://dx.doi.org/10.3390/children10050826
_version_ 1785048425191964672
author Koulouraki, Sevasti
Paschos, Vasileios
Pervanidou, Panagiota
Christopoulos, Panagiotis
Gerede, Angeliki
Eleftheriades, Makarios
author_facet Koulouraki, Sevasti
Paschos, Vasileios
Pervanidou, Panagiota
Christopoulos, Panagiotis
Gerede, Angeliki
Eleftheriades, Makarios
author_sort Koulouraki, Sevasti
collection PubMed
description Preeclampsia is a multisystemic clinical syndrome characterized by the appearance of new-onset hypertension and proteinuria or hypertension and end organ dysfunction even without proteinuria after 20 weeks of pregnancy or postpartum. Residing at the severe end of the spectrum of the hypertensive disorders of pregnancy, preeclampsia occurs in 3 to 8% of pregnancies worldwide and is a major cause of maternal and perinatal morbidity and mortality, accounting for 8–10% of all preterm births. The mechanism whereby preeclampsia increases the risk of the neurodevelopmental, cardiovascular, and metabolic morbidity of the mother’s offspring is not well known, but it is possible that the preeclamptic environment induces epigenetic changes that adversely affect developmental plasticity. These developmental changes are crucial for optimal fetal growth and survival but may lead to an increased risk of chronic morbidity in childhood and even later in life. The aim of this review is to summarize both the short- and long-term effects of preeclampsia on offspring based on the current literature.
format Online
Article
Text
id pubmed-10216976
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-102169762023-05-27 Short- and Long-Term Outcomes of Preeclampsia in Offspring: Review of the Literature Koulouraki, Sevasti Paschos, Vasileios Pervanidou, Panagiota Christopoulos, Panagiotis Gerede, Angeliki Eleftheriades, Makarios Children (Basel) Review Preeclampsia is a multisystemic clinical syndrome characterized by the appearance of new-onset hypertension and proteinuria or hypertension and end organ dysfunction even without proteinuria after 20 weeks of pregnancy or postpartum. Residing at the severe end of the spectrum of the hypertensive disorders of pregnancy, preeclampsia occurs in 3 to 8% of pregnancies worldwide and is a major cause of maternal and perinatal morbidity and mortality, accounting for 8–10% of all preterm births. The mechanism whereby preeclampsia increases the risk of the neurodevelopmental, cardiovascular, and metabolic morbidity of the mother’s offspring is not well known, but it is possible that the preeclamptic environment induces epigenetic changes that adversely affect developmental plasticity. These developmental changes are crucial for optimal fetal growth and survival but may lead to an increased risk of chronic morbidity in childhood and even later in life. The aim of this review is to summarize both the short- and long-term effects of preeclampsia on offspring based on the current literature. MDPI 2023-05-01 /pmc/articles/PMC10216976/ /pubmed/37238374 http://dx.doi.org/10.3390/children10050826 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Koulouraki, Sevasti
Paschos, Vasileios
Pervanidou, Panagiota
Christopoulos, Panagiotis
Gerede, Angeliki
Eleftheriades, Makarios
Short- and Long-Term Outcomes of Preeclampsia in Offspring: Review of the Literature
title Short- and Long-Term Outcomes of Preeclampsia in Offspring: Review of the Literature
title_full Short- and Long-Term Outcomes of Preeclampsia in Offspring: Review of the Literature
title_fullStr Short- and Long-Term Outcomes of Preeclampsia in Offspring: Review of the Literature
title_full_unstemmed Short- and Long-Term Outcomes of Preeclampsia in Offspring: Review of the Literature
title_short Short- and Long-Term Outcomes of Preeclampsia in Offspring: Review of the Literature
title_sort short- and long-term outcomes of preeclampsia in offspring: review of the literature
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10216976/
https://www.ncbi.nlm.nih.gov/pubmed/37238374
http://dx.doi.org/10.3390/children10050826
work_keys_str_mv AT koulourakisevasti shortandlongtermoutcomesofpreeclampsiainoffspringreviewoftheliterature
AT paschosvasileios shortandlongtermoutcomesofpreeclampsiainoffspringreviewoftheliterature
AT pervanidoupanagiota shortandlongtermoutcomesofpreeclampsiainoffspringreviewoftheliterature
AT christopoulospanagiotis shortandlongtermoutcomesofpreeclampsiainoffspringreviewoftheliterature
AT geredeangeliki shortandlongtermoutcomesofpreeclampsiainoffspringreviewoftheliterature
AT eleftheriadesmakarios shortandlongtermoutcomesofpreeclampsiainoffspringreviewoftheliterature