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Painless Capillary Blood Collection: A Rapid Evaluation of the Onflow Device

Blood-based diagnostics are critical for many medical decisions, but mostly rely on venepuncture, which can be inconvenient and painful. The Onflow Serum Gel (Loop Medical SA, Vaud, Lausanne, Switzerland) is a novel blood collection device that utilises needle-free technology to collect capillary bl...

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Autores principales: Noble, Lara Dominique, Dixon, Caitlin, Moran, Alison, Trottet, Charlotte, Majam, Mohammed, Ismail, Shameema, Msolomba, Vanessa Tiyamike, Mathobela, Kegomoditswe, Queval, Arthur, George, Jaya, Scott, Lesley Erica, Stevens, Wendy Susan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10217062/
https://www.ncbi.nlm.nih.gov/pubmed/37238237
http://dx.doi.org/10.3390/diagnostics13101754
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author Noble, Lara Dominique
Dixon, Caitlin
Moran, Alison
Trottet, Charlotte
Majam, Mohammed
Ismail, Shameema
Msolomba, Vanessa Tiyamike
Mathobela, Kegomoditswe
Queval, Arthur
George, Jaya
Scott, Lesley Erica
Stevens, Wendy Susan
author_facet Noble, Lara Dominique
Dixon, Caitlin
Moran, Alison
Trottet, Charlotte
Majam, Mohammed
Ismail, Shameema
Msolomba, Vanessa Tiyamike
Mathobela, Kegomoditswe
Queval, Arthur
George, Jaya
Scott, Lesley Erica
Stevens, Wendy Susan
author_sort Noble, Lara Dominique
collection PubMed
description Blood-based diagnostics are critical for many medical decisions, but mostly rely on venepuncture, which can be inconvenient and painful. The Onflow Serum Gel (Loop Medical SA, Vaud, Lausanne, Switzerland) is a novel blood collection device that utilises needle-free technology to collect capillary blood. In this pilot study, 100 healthy participants were enrolled and provided two Onflow collected specimens and one venous blood specimen. Five chemistry analytes (AST, ALT, LDH, potassium, creatinine) and haemolysis were measured per specimen, and laboratory analyte results were compared. Onflow was found to be more acceptable than venepuncture with lower pain ratings, and 96.5% of participants would use the Onflow method again. All phlebotomists (100%) found Onflow intuitive and user-friendly, with ~1 mL of Onflow blood successfully collected from 99% of participants in <12 min (mean: 6 min, 40 s) and 91% collected on the first attempt. ALT and AST analytes showed no difference in performance, while creatinine generated a negative bias (−5.6 µmol/L), and increased variability was noted with potassium (3.6%CV) and LDH (6.7%CV), although none were clinically relevant. These differences may be due to 35% of Onflow collected specimens having “mild” haemolysis. Onflow is a promising alternative blood collection device that should now be evaluated in participants with expected abnormal chemistries and as an option for self-collection.
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spelling pubmed-102170622023-05-27 Painless Capillary Blood Collection: A Rapid Evaluation of the Onflow Device Noble, Lara Dominique Dixon, Caitlin Moran, Alison Trottet, Charlotte Majam, Mohammed Ismail, Shameema Msolomba, Vanessa Tiyamike Mathobela, Kegomoditswe Queval, Arthur George, Jaya Scott, Lesley Erica Stevens, Wendy Susan Diagnostics (Basel) Article Blood-based diagnostics are critical for many medical decisions, but mostly rely on venepuncture, which can be inconvenient and painful. The Onflow Serum Gel (Loop Medical SA, Vaud, Lausanne, Switzerland) is a novel blood collection device that utilises needle-free technology to collect capillary blood. In this pilot study, 100 healthy participants were enrolled and provided two Onflow collected specimens and one venous blood specimen. Five chemistry analytes (AST, ALT, LDH, potassium, creatinine) and haemolysis were measured per specimen, and laboratory analyte results were compared. Onflow was found to be more acceptable than venepuncture with lower pain ratings, and 96.5% of participants would use the Onflow method again. All phlebotomists (100%) found Onflow intuitive and user-friendly, with ~1 mL of Onflow blood successfully collected from 99% of participants in <12 min (mean: 6 min, 40 s) and 91% collected on the first attempt. ALT and AST analytes showed no difference in performance, while creatinine generated a negative bias (−5.6 µmol/L), and increased variability was noted with potassium (3.6%CV) and LDH (6.7%CV), although none were clinically relevant. These differences may be due to 35% of Onflow collected specimens having “mild” haemolysis. Onflow is a promising alternative blood collection device that should now be evaluated in participants with expected abnormal chemistries and as an option for self-collection. MDPI 2023-05-16 /pmc/articles/PMC10217062/ /pubmed/37238237 http://dx.doi.org/10.3390/diagnostics13101754 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Noble, Lara Dominique
Dixon, Caitlin
Moran, Alison
Trottet, Charlotte
Majam, Mohammed
Ismail, Shameema
Msolomba, Vanessa Tiyamike
Mathobela, Kegomoditswe
Queval, Arthur
George, Jaya
Scott, Lesley Erica
Stevens, Wendy Susan
Painless Capillary Blood Collection: A Rapid Evaluation of the Onflow Device
title Painless Capillary Blood Collection: A Rapid Evaluation of the Onflow Device
title_full Painless Capillary Blood Collection: A Rapid Evaluation of the Onflow Device
title_fullStr Painless Capillary Blood Collection: A Rapid Evaluation of the Onflow Device
title_full_unstemmed Painless Capillary Blood Collection: A Rapid Evaluation of the Onflow Device
title_short Painless Capillary Blood Collection: A Rapid Evaluation of the Onflow Device
title_sort painless capillary blood collection: a rapid evaluation of the onflow device
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10217062/
https://www.ncbi.nlm.nih.gov/pubmed/37238237
http://dx.doi.org/10.3390/diagnostics13101754
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