Cargando…
Aβ Oligomer Toxicity-Reducing Therapy for the Prevention of Alzheimer’s Disease: Importance of the Nrf2 and PPARγ Pathways
Recent studies have revealed that soluble amyloid-β oligomers (AβOs) play a pathogenetic role in Alzheimer’s disease (AD). Indeed, AβOs induce neurotoxic and synaptotoxic effects and are also critically involved in neuroinflammation. Oxidative stress appears to be a crucial event underlying these pa...
Autor principal: | Araki, Wataru |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10217070/ https://www.ncbi.nlm.nih.gov/pubmed/37408220 http://dx.doi.org/10.3390/cells12101386 |
Ejemplares similares
-
Protection against Amyloid-β Oligomer Neurotoxicity by Small Molecules with Antioxidative Properties: Potential for the Prevention of Alzheimer’s Disease Dementia
por: Araki, Wataru, et al.
Publicado: (2022) -
Reversibility of Aβ oligomer neurotoxicity
por: Araki, Wataru
Publicado: (2017) -
PPARγ and Oxidative Stress: Con(β) Catenating NRF2 and FOXO
por: Polvani, Simone, et al.
Publicado: (2012) -
Cellular Prion Protein as a Receptor of Toxic Amyloid-β42 Oligomers Is Important for Alzheimer’s Disease
por: Zhang, Yuan, et al.
Publicado: (2019) -
Peripheral administration of nanomicelle-encapsulated anti-Aβ oligomer fragment antibody reduces various toxic Aβ species in the brain
por: Amano, Akiko, et al.
Publicado: (2023)