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Home-Based Exercise Training in the Recovery of Multisystem Inflammatory Syndrome in Children: A Case Series Study

Objective: To assess the potential therapeutic role of exercise on health-related quality of life, assessed by the Pediatric Outcomes Data Collection Instrument (PODCI), coronary flow reserve (CFR), cardiac function, cardiorespiratory fitness, and inflammatory and cardiac blood markers in multisyste...

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Autores principales: Astley, Camilla, Leal, Gabriela Nunes, Gil, Saulo, Suguita, Priscila, Fink, Thais, Bain, Vera, Pereira, Maria Fernanda Badue, Marques, Heloisa Helena, Sieczkowska, Sofia, Prado, Danilo, Lima, Marcos Santos, Carneiro, Camila G., Buchpiguel, Carlos Alberto, Silva, Clovis Artur, Gualano, Bruno
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10217147/
https://www.ncbi.nlm.nih.gov/pubmed/37238437
http://dx.doi.org/10.3390/children10050889
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author Astley, Camilla
Leal, Gabriela Nunes
Gil, Saulo
Suguita, Priscila
Fink, Thais
Bain, Vera
Pereira, Maria Fernanda Badue
Marques, Heloisa Helena
Sieczkowska, Sofia
Prado, Danilo
Lima, Marcos Santos
Carneiro, Camila G.
Buchpiguel, Carlos Alberto
Silva, Clovis Artur
Gualano, Bruno
author_facet Astley, Camilla
Leal, Gabriela Nunes
Gil, Saulo
Suguita, Priscila
Fink, Thais
Bain, Vera
Pereira, Maria Fernanda Badue
Marques, Heloisa Helena
Sieczkowska, Sofia
Prado, Danilo
Lima, Marcos Santos
Carneiro, Camila G.
Buchpiguel, Carlos Alberto
Silva, Clovis Artur
Gualano, Bruno
author_sort Astley, Camilla
collection PubMed
description Objective: To assess the potential therapeutic role of exercise on health-related quality of life, assessed by the Pediatric Outcomes Data Collection Instrument (PODCI), coronary flow reserve (CFR), cardiac function, cardiorespiratory fitness, and inflammatory and cardiac blood markers in multisystemic inflammatory syndrome in children (MIS-C) patients. Methods: This is a case series study of a 12-wk, home-based exercise intervention in children and adolescents after MIS-C diagnosis. From 16 MIS-C patients followed at our clinic, 6 were included (age: 7–16 years; 3 females). Three of them withdrew before the intervention and served as controls. The primary outcome was health-related quality of life, assessed PODCI. Secondary outcomes were CFR assessed by 13N-ammonia PET-CT imaging, cardiac function by echocardiography, cardiorespiratory fitness, and inflammatory and cardiac blood markers. Results: In general, patients showed poor health-related quality of life, which seemed to be improved with exercise. Additionally, exercised patients showed improvements in coronary flow reserve, cardiac function, and aerobic conditioning. Non-exercised patients exhibited a slower pattern of recovery, particularly in relation to health-related quality of life and aerobic conditioning. Conclusions: Our results suggest that exercise may play a therapeutic role in the treatment of post-discharge MIS-C patients. As our design does not allow inferring causality, randomized controlled trials are necessary to confirm these preliminary findings.
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spelling pubmed-102171472023-05-27 Home-Based Exercise Training in the Recovery of Multisystem Inflammatory Syndrome in Children: A Case Series Study Astley, Camilla Leal, Gabriela Nunes Gil, Saulo Suguita, Priscila Fink, Thais Bain, Vera Pereira, Maria Fernanda Badue Marques, Heloisa Helena Sieczkowska, Sofia Prado, Danilo Lima, Marcos Santos Carneiro, Camila G. Buchpiguel, Carlos Alberto Silva, Clovis Artur Gualano, Bruno Children (Basel) Article Objective: To assess the potential therapeutic role of exercise on health-related quality of life, assessed by the Pediatric Outcomes Data Collection Instrument (PODCI), coronary flow reserve (CFR), cardiac function, cardiorespiratory fitness, and inflammatory and cardiac blood markers in multisystemic inflammatory syndrome in children (MIS-C) patients. Methods: This is a case series study of a 12-wk, home-based exercise intervention in children and adolescents after MIS-C diagnosis. From 16 MIS-C patients followed at our clinic, 6 were included (age: 7–16 years; 3 females). Three of them withdrew before the intervention and served as controls. The primary outcome was health-related quality of life, assessed PODCI. Secondary outcomes were CFR assessed by 13N-ammonia PET-CT imaging, cardiac function by echocardiography, cardiorespiratory fitness, and inflammatory and cardiac blood markers. Results: In general, patients showed poor health-related quality of life, which seemed to be improved with exercise. Additionally, exercised patients showed improvements in coronary flow reserve, cardiac function, and aerobic conditioning. Non-exercised patients exhibited a slower pattern of recovery, particularly in relation to health-related quality of life and aerobic conditioning. Conclusions: Our results suggest that exercise may play a therapeutic role in the treatment of post-discharge MIS-C patients. As our design does not allow inferring causality, randomized controlled trials are necessary to confirm these preliminary findings. MDPI 2023-05-16 /pmc/articles/PMC10217147/ /pubmed/37238437 http://dx.doi.org/10.3390/children10050889 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Astley, Camilla
Leal, Gabriela Nunes
Gil, Saulo
Suguita, Priscila
Fink, Thais
Bain, Vera
Pereira, Maria Fernanda Badue
Marques, Heloisa Helena
Sieczkowska, Sofia
Prado, Danilo
Lima, Marcos Santos
Carneiro, Camila G.
Buchpiguel, Carlos Alberto
Silva, Clovis Artur
Gualano, Bruno
Home-Based Exercise Training in the Recovery of Multisystem Inflammatory Syndrome in Children: A Case Series Study
title Home-Based Exercise Training in the Recovery of Multisystem Inflammatory Syndrome in Children: A Case Series Study
title_full Home-Based Exercise Training in the Recovery of Multisystem Inflammatory Syndrome in Children: A Case Series Study
title_fullStr Home-Based Exercise Training in the Recovery of Multisystem Inflammatory Syndrome in Children: A Case Series Study
title_full_unstemmed Home-Based Exercise Training in the Recovery of Multisystem Inflammatory Syndrome in Children: A Case Series Study
title_short Home-Based Exercise Training in the Recovery of Multisystem Inflammatory Syndrome in Children: A Case Series Study
title_sort home-based exercise training in the recovery of multisystem inflammatory syndrome in children: a case series study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10217147/
https://www.ncbi.nlm.nih.gov/pubmed/37238437
http://dx.doi.org/10.3390/children10050889
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