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Home-Based Exercise Training in the Recovery of Multisystem Inflammatory Syndrome in Children: A Case Series Study
Objective: To assess the potential therapeutic role of exercise on health-related quality of life, assessed by the Pediatric Outcomes Data Collection Instrument (PODCI), coronary flow reserve (CFR), cardiac function, cardiorespiratory fitness, and inflammatory and cardiac blood markers in multisyste...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10217147/ https://www.ncbi.nlm.nih.gov/pubmed/37238437 http://dx.doi.org/10.3390/children10050889 |
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author | Astley, Camilla Leal, Gabriela Nunes Gil, Saulo Suguita, Priscila Fink, Thais Bain, Vera Pereira, Maria Fernanda Badue Marques, Heloisa Helena Sieczkowska, Sofia Prado, Danilo Lima, Marcos Santos Carneiro, Camila G. Buchpiguel, Carlos Alberto Silva, Clovis Artur Gualano, Bruno |
author_facet | Astley, Camilla Leal, Gabriela Nunes Gil, Saulo Suguita, Priscila Fink, Thais Bain, Vera Pereira, Maria Fernanda Badue Marques, Heloisa Helena Sieczkowska, Sofia Prado, Danilo Lima, Marcos Santos Carneiro, Camila G. Buchpiguel, Carlos Alberto Silva, Clovis Artur Gualano, Bruno |
author_sort | Astley, Camilla |
collection | PubMed |
description | Objective: To assess the potential therapeutic role of exercise on health-related quality of life, assessed by the Pediatric Outcomes Data Collection Instrument (PODCI), coronary flow reserve (CFR), cardiac function, cardiorespiratory fitness, and inflammatory and cardiac blood markers in multisystemic inflammatory syndrome in children (MIS-C) patients. Methods: This is a case series study of a 12-wk, home-based exercise intervention in children and adolescents after MIS-C diagnosis. From 16 MIS-C patients followed at our clinic, 6 were included (age: 7–16 years; 3 females). Three of them withdrew before the intervention and served as controls. The primary outcome was health-related quality of life, assessed PODCI. Secondary outcomes were CFR assessed by 13N-ammonia PET-CT imaging, cardiac function by echocardiography, cardiorespiratory fitness, and inflammatory and cardiac blood markers. Results: In general, patients showed poor health-related quality of life, which seemed to be improved with exercise. Additionally, exercised patients showed improvements in coronary flow reserve, cardiac function, and aerobic conditioning. Non-exercised patients exhibited a slower pattern of recovery, particularly in relation to health-related quality of life and aerobic conditioning. Conclusions: Our results suggest that exercise may play a therapeutic role in the treatment of post-discharge MIS-C patients. As our design does not allow inferring causality, randomized controlled trials are necessary to confirm these preliminary findings. |
format | Online Article Text |
id | pubmed-10217147 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-102171472023-05-27 Home-Based Exercise Training in the Recovery of Multisystem Inflammatory Syndrome in Children: A Case Series Study Astley, Camilla Leal, Gabriela Nunes Gil, Saulo Suguita, Priscila Fink, Thais Bain, Vera Pereira, Maria Fernanda Badue Marques, Heloisa Helena Sieczkowska, Sofia Prado, Danilo Lima, Marcos Santos Carneiro, Camila G. Buchpiguel, Carlos Alberto Silva, Clovis Artur Gualano, Bruno Children (Basel) Article Objective: To assess the potential therapeutic role of exercise on health-related quality of life, assessed by the Pediatric Outcomes Data Collection Instrument (PODCI), coronary flow reserve (CFR), cardiac function, cardiorespiratory fitness, and inflammatory and cardiac blood markers in multisystemic inflammatory syndrome in children (MIS-C) patients. Methods: This is a case series study of a 12-wk, home-based exercise intervention in children and adolescents after MIS-C diagnosis. From 16 MIS-C patients followed at our clinic, 6 were included (age: 7–16 years; 3 females). Three of them withdrew before the intervention and served as controls. The primary outcome was health-related quality of life, assessed PODCI. Secondary outcomes were CFR assessed by 13N-ammonia PET-CT imaging, cardiac function by echocardiography, cardiorespiratory fitness, and inflammatory and cardiac blood markers. Results: In general, patients showed poor health-related quality of life, which seemed to be improved with exercise. Additionally, exercised patients showed improvements in coronary flow reserve, cardiac function, and aerobic conditioning. Non-exercised patients exhibited a slower pattern of recovery, particularly in relation to health-related quality of life and aerobic conditioning. Conclusions: Our results suggest that exercise may play a therapeutic role in the treatment of post-discharge MIS-C patients. As our design does not allow inferring causality, randomized controlled trials are necessary to confirm these preliminary findings. MDPI 2023-05-16 /pmc/articles/PMC10217147/ /pubmed/37238437 http://dx.doi.org/10.3390/children10050889 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Astley, Camilla Leal, Gabriela Nunes Gil, Saulo Suguita, Priscila Fink, Thais Bain, Vera Pereira, Maria Fernanda Badue Marques, Heloisa Helena Sieczkowska, Sofia Prado, Danilo Lima, Marcos Santos Carneiro, Camila G. Buchpiguel, Carlos Alberto Silva, Clovis Artur Gualano, Bruno Home-Based Exercise Training in the Recovery of Multisystem Inflammatory Syndrome in Children: A Case Series Study |
title | Home-Based Exercise Training in the Recovery of Multisystem Inflammatory Syndrome in Children: A Case Series Study |
title_full | Home-Based Exercise Training in the Recovery of Multisystem Inflammatory Syndrome in Children: A Case Series Study |
title_fullStr | Home-Based Exercise Training in the Recovery of Multisystem Inflammatory Syndrome in Children: A Case Series Study |
title_full_unstemmed | Home-Based Exercise Training in the Recovery of Multisystem Inflammatory Syndrome in Children: A Case Series Study |
title_short | Home-Based Exercise Training in the Recovery of Multisystem Inflammatory Syndrome in Children: A Case Series Study |
title_sort | home-based exercise training in the recovery of multisystem inflammatory syndrome in children: a case series study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10217147/ https://www.ncbi.nlm.nih.gov/pubmed/37238437 http://dx.doi.org/10.3390/children10050889 |
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