A Case Report of Early-Onset Alzheimer’s Disease Using (18)F-FDG PET and (18)F-FBB PET

We describe a 40-year-old female patient who presented with sleep disturbance, intermittent headache, and gradual subjective cognitive decline. (18)F-fluorodeoxyglucose (FDG) positron emission tomography (PET) showed mild FDG hypometabolism in bilateral parietal and temporal lobes. However, (18)F-fl...

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Detalles Bibliográficos
Autores principales: Yoo, Jang, Cheon, Miju, Kang, Min-Ju
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10217176/
https://www.ncbi.nlm.nih.gov/pubmed/37238154
http://dx.doi.org/10.3390/diagnostics13101671
Descripción
Sumario:We describe a 40-year-old female patient who presented with sleep disturbance, intermittent headache, and gradual subjective cognitive decline. (18)F-fluorodeoxyglucose (FDG) positron emission tomography (PET) showed mild FDG hypometabolism in bilateral parietal and temporal lobes. However, (18)F-florbetaben (FBB) amyloid PET revealed diffuse amyloid retention in the lateral temporal cortex, frontal cortex, posterior cingulate cortex/precuneus, parietal cortex, and cerebellum. This finding supports the clinical significance of amyloid imaging in diagnostic work-up of early-onset Alzheimer’s disease (EOAD).

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