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Information Encoding in Bursting Spiking Neural Network Modulated by Astrocytes
We investigated a mathematical model composed of a spiking neural network (SNN) interacting with astrocytes. We analysed how information content in the form of two-dimensional images can be represented by an SNN in the form of a spatiotemporal spiking pattern. The SNN includes excitatory and inhibit...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10217185/ https://www.ncbi.nlm.nih.gov/pubmed/37238500 http://dx.doi.org/10.3390/e25050745 |
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author | Stasenko, Sergey V. Kazantsev, Victor B. |
author_facet | Stasenko, Sergey V. Kazantsev, Victor B. |
author_sort | Stasenko, Sergey V. |
collection | PubMed |
description | We investigated a mathematical model composed of a spiking neural network (SNN) interacting with astrocytes. We analysed how information content in the form of two-dimensional images can be represented by an SNN in the form of a spatiotemporal spiking pattern. The SNN includes excitatory and inhibitory neurons in some proportion, sustaining the excitation–inhibition balance of autonomous firing. The astrocytes accompanying each excitatory synapse provide a slow modulation of synaptic transmission strength. An information image was uploaded to the network in the form of excitatory stimulation pulses distributed in time reproducing the shape of the image. We found that astrocytic modulation prevented stimulation-induced SNN hyperexcitation and non-periodic bursting activity. Such homeostatic astrocytic regulation of neuronal activity makes it possible to restore the image supplied during stimulation and lost in the raster diagram of neuronal activity due to non-periodic neuronal firing. At a biological point, our model shows that astrocytes can act as an additional adaptive mechanism for regulating neural activity, which is crucial for sensory cortical representations. |
format | Online Article Text |
id | pubmed-10217185 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-102171852023-05-27 Information Encoding in Bursting Spiking Neural Network Modulated by Astrocytes Stasenko, Sergey V. Kazantsev, Victor B. Entropy (Basel) Article We investigated a mathematical model composed of a spiking neural network (SNN) interacting with astrocytes. We analysed how information content in the form of two-dimensional images can be represented by an SNN in the form of a spatiotemporal spiking pattern. The SNN includes excitatory and inhibitory neurons in some proportion, sustaining the excitation–inhibition balance of autonomous firing. The astrocytes accompanying each excitatory synapse provide a slow modulation of synaptic transmission strength. An information image was uploaded to the network in the form of excitatory stimulation pulses distributed in time reproducing the shape of the image. We found that astrocytic modulation prevented stimulation-induced SNN hyperexcitation and non-periodic bursting activity. Such homeostatic astrocytic regulation of neuronal activity makes it possible to restore the image supplied during stimulation and lost in the raster diagram of neuronal activity due to non-periodic neuronal firing. At a biological point, our model shows that astrocytes can act as an additional adaptive mechanism for regulating neural activity, which is crucial for sensory cortical representations. MDPI 2023-05-01 /pmc/articles/PMC10217185/ /pubmed/37238500 http://dx.doi.org/10.3390/e25050745 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Stasenko, Sergey V. Kazantsev, Victor B. Information Encoding in Bursting Spiking Neural Network Modulated by Astrocytes |
title | Information Encoding in Bursting Spiking Neural Network Modulated by Astrocytes |
title_full | Information Encoding in Bursting Spiking Neural Network Modulated by Astrocytes |
title_fullStr | Information Encoding in Bursting Spiking Neural Network Modulated by Astrocytes |
title_full_unstemmed | Information Encoding in Bursting Spiking Neural Network Modulated by Astrocytes |
title_short | Information Encoding in Bursting Spiking Neural Network Modulated by Astrocytes |
title_sort | information encoding in bursting spiking neural network modulated by astrocytes |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10217185/ https://www.ncbi.nlm.nih.gov/pubmed/37238500 http://dx.doi.org/10.3390/e25050745 |
work_keys_str_mv | AT stasenkosergeyv informationencodinginburstingspikingneuralnetworkmodulatedbyastrocytes AT kazantsevvictorb informationencodinginburstingspikingneuralnetworkmodulatedbyastrocytes |