Cargando…

Information Encoding in Bursting Spiking Neural Network Modulated by Astrocytes

We investigated a mathematical model composed of a spiking neural network (SNN) interacting with astrocytes. We analysed how information content in the form of two-dimensional images can be represented by an SNN in the form of a spatiotemporal spiking pattern. The SNN includes excitatory and inhibit...

Descripción completa

Detalles Bibliográficos
Autores principales: Stasenko, Sergey V., Kazantsev, Victor B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10217185/
https://www.ncbi.nlm.nih.gov/pubmed/37238500
http://dx.doi.org/10.3390/e25050745
_version_ 1785048476242935808
author Stasenko, Sergey V.
Kazantsev, Victor B.
author_facet Stasenko, Sergey V.
Kazantsev, Victor B.
author_sort Stasenko, Sergey V.
collection PubMed
description We investigated a mathematical model composed of a spiking neural network (SNN) interacting with astrocytes. We analysed how information content in the form of two-dimensional images can be represented by an SNN in the form of a spatiotemporal spiking pattern. The SNN includes excitatory and inhibitory neurons in some proportion, sustaining the excitation–inhibition balance of autonomous firing. The astrocytes accompanying each excitatory synapse provide a slow modulation of synaptic transmission strength. An information image was uploaded to the network in the form of excitatory stimulation pulses distributed in time reproducing the shape of the image. We found that astrocytic modulation prevented stimulation-induced SNN hyperexcitation and non-periodic bursting activity. Such homeostatic astrocytic regulation of neuronal activity makes it possible to restore the image supplied during stimulation and lost in the raster diagram of neuronal activity due to non-periodic neuronal firing. At a biological point, our model shows that astrocytes can act as an additional adaptive mechanism for regulating neural activity, which is crucial for sensory cortical representations.
format Online
Article
Text
id pubmed-10217185
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-102171852023-05-27 Information Encoding in Bursting Spiking Neural Network Modulated by Astrocytes Stasenko, Sergey V. Kazantsev, Victor B. Entropy (Basel) Article We investigated a mathematical model composed of a spiking neural network (SNN) interacting with astrocytes. We analysed how information content in the form of two-dimensional images can be represented by an SNN in the form of a spatiotemporal spiking pattern. The SNN includes excitatory and inhibitory neurons in some proportion, sustaining the excitation–inhibition balance of autonomous firing. The astrocytes accompanying each excitatory synapse provide a slow modulation of synaptic transmission strength. An information image was uploaded to the network in the form of excitatory stimulation pulses distributed in time reproducing the shape of the image. We found that astrocytic modulation prevented stimulation-induced SNN hyperexcitation and non-periodic bursting activity. Such homeostatic astrocytic regulation of neuronal activity makes it possible to restore the image supplied during stimulation and lost in the raster diagram of neuronal activity due to non-periodic neuronal firing. At a biological point, our model shows that astrocytes can act as an additional adaptive mechanism for regulating neural activity, which is crucial for sensory cortical representations. MDPI 2023-05-01 /pmc/articles/PMC10217185/ /pubmed/37238500 http://dx.doi.org/10.3390/e25050745 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Stasenko, Sergey V.
Kazantsev, Victor B.
Information Encoding in Bursting Spiking Neural Network Modulated by Astrocytes
title Information Encoding in Bursting Spiking Neural Network Modulated by Astrocytes
title_full Information Encoding in Bursting Spiking Neural Network Modulated by Astrocytes
title_fullStr Information Encoding in Bursting Spiking Neural Network Modulated by Astrocytes
title_full_unstemmed Information Encoding in Bursting Spiking Neural Network Modulated by Astrocytes
title_short Information Encoding in Bursting Spiking Neural Network Modulated by Astrocytes
title_sort information encoding in bursting spiking neural network modulated by astrocytes
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10217185/
https://www.ncbi.nlm.nih.gov/pubmed/37238500
http://dx.doi.org/10.3390/e25050745
work_keys_str_mv AT stasenkosergeyv informationencodinginburstingspikingneuralnetworkmodulatedbyastrocytes
AT kazantsevvictorb informationencodinginburstingspikingneuralnetworkmodulatedbyastrocytes