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Intra- and Juxta-Articular Osteoid Osteoma Mimicking Arthritis: Case Series and Literature Review

Background: Intra- and juxta-articular osteoid osteomas are rare, representing less than 10% of all osteomas. Compared to the classic diaphyseal or metaphyseal site of long bones, they often have an atypical onset, a longest diagnostic delay, and frequent initial misdiagnoses, with pictures that can...

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Autores principales: Civino, Adele, Diomeda, Federico, Giordano, Luca, Damasio, Maria Beatrice, Perrone, Sandra, Gallizzi, Romina, Ravelli, Angelo, Piscitelli, Prisco, Maggio, Maria Cristina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10217229/
https://www.ncbi.nlm.nih.gov/pubmed/37238377
http://dx.doi.org/10.3390/children10050829
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author Civino, Adele
Diomeda, Federico
Giordano, Luca
Damasio, Maria Beatrice
Perrone, Sandra
Gallizzi, Romina
Ravelli, Angelo
Piscitelli, Prisco
Maggio, Maria Cristina
author_facet Civino, Adele
Diomeda, Federico
Giordano, Luca
Damasio, Maria Beatrice
Perrone, Sandra
Gallizzi, Romina
Ravelli, Angelo
Piscitelli, Prisco
Maggio, Maria Cristina
author_sort Civino, Adele
collection PubMed
description Background: Intra- and juxta-articular osteoid osteomas are rare, representing less than 10% of all osteomas. Compared to the classic diaphyseal or metaphyseal site of long bones, they often have an atypical onset, a longest diagnostic delay, and frequent initial misdiagnoses, with pictures that can mimic inflammatory monoarthritis. We aimed to describe a case series, and to provide a literature review of this uncommon and misleading tumor location. Methods: We performed a retrospective analysis of patients referred to three pediatric rheumatology centers, with a final diagnosis of articular osteoid osteoma. A review of the literature was additionally conducted. Results: We included 10 patients with a mean age of 14 years. All patients with unusual sites (olecranon fossa, lumbar vertebra, distal phalanx of the toe, fibula) had a misdiagnosis, and cases with initial suspicion of monoarthritis had the longest diagnostic delay, up to 24 months. The literature review confirms the significant risk of misdiagnosis, and an average time from symptom onset to diagnosis ranging from 0.4 to 1.8 years. Conclusions: Articular osteoid osteoma may mimic arthritis, especially in adolescence. Knowledge of the atypical forms of presentation, and of the clinical and radiological pitfalls, reduces the risk of diagnostic error.
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spelling pubmed-102172292023-05-27 Intra- and Juxta-Articular Osteoid Osteoma Mimicking Arthritis: Case Series and Literature Review Civino, Adele Diomeda, Federico Giordano, Luca Damasio, Maria Beatrice Perrone, Sandra Gallizzi, Romina Ravelli, Angelo Piscitelli, Prisco Maggio, Maria Cristina Children (Basel) Article Background: Intra- and juxta-articular osteoid osteomas are rare, representing less than 10% of all osteomas. Compared to the classic diaphyseal or metaphyseal site of long bones, they often have an atypical onset, a longest diagnostic delay, and frequent initial misdiagnoses, with pictures that can mimic inflammatory monoarthritis. We aimed to describe a case series, and to provide a literature review of this uncommon and misleading tumor location. Methods: We performed a retrospective analysis of patients referred to three pediatric rheumatology centers, with a final diagnosis of articular osteoid osteoma. A review of the literature was additionally conducted. Results: We included 10 patients with a mean age of 14 years. All patients with unusual sites (olecranon fossa, lumbar vertebra, distal phalanx of the toe, fibula) had a misdiagnosis, and cases with initial suspicion of monoarthritis had the longest diagnostic delay, up to 24 months. The literature review confirms the significant risk of misdiagnosis, and an average time from symptom onset to diagnosis ranging from 0.4 to 1.8 years. Conclusions: Articular osteoid osteoma may mimic arthritis, especially in adolescence. Knowledge of the atypical forms of presentation, and of the clinical and radiological pitfalls, reduces the risk of diagnostic error. MDPI 2023-05-02 /pmc/articles/PMC10217229/ /pubmed/37238377 http://dx.doi.org/10.3390/children10050829 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Civino, Adele
Diomeda, Federico
Giordano, Luca
Damasio, Maria Beatrice
Perrone, Sandra
Gallizzi, Romina
Ravelli, Angelo
Piscitelli, Prisco
Maggio, Maria Cristina
Intra- and Juxta-Articular Osteoid Osteoma Mimicking Arthritis: Case Series and Literature Review
title Intra- and Juxta-Articular Osteoid Osteoma Mimicking Arthritis: Case Series and Literature Review
title_full Intra- and Juxta-Articular Osteoid Osteoma Mimicking Arthritis: Case Series and Literature Review
title_fullStr Intra- and Juxta-Articular Osteoid Osteoma Mimicking Arthritis: Case Series and Literature Review
title_full_unstemmed Intra- and Juxta-Articular Osteoid Osteoma Mimicking Arthritis: Case Series and Literature Review
title_short Intra- and Juxta-Articular Osteoid Osteoma Mimicking Arthritis: Case Series and Literature Review
title_sort intra- and juxta-articular osteoid osteoma mimicking arthritis: case series and literature review
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10217229/
https://www.ncbi.nlm.nih.gov/pubmed/37238377
http://dx.doi.org/10.3390/children10050829
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