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Should Laparoscopic Complete Mesocolic Excision Be Offered to Elderly Patients to Treat Right-Sided Colon Cancer?

Background: Despite its potential oncologic benefit, complete mesocolic excision (CME) has rarely been offered to elderly patients. The present study evaluated the effect of age on postoperative outcomes among patients undergoing laparoscopic right colectomies with CME for right-sided colon cancer (...

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Autores principales: Mazzola, Michele, Ripamonti, Lorenzo, Giani, Alessandro, Carnevali, Pietro, Origi, Matteo, Alampi, BrunocDomenico, Giusti, Irene, Achilli, Pietro, Bertoglio, Camillo Leonardo, Magistro, Carmelo, Ferrari, Giovanni
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10217306/
https://www.ncbi.nlm.nih.gov/pubmed/37232834
http://dx.doi.org/10.3390/curroncol30050376
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author Mazzola, Michele
Ripamonti, Lorenzo
Giani, Alessandro
Carnevali, Pietro
Origi, Matteo
Alampi, BrunocDomenico
Giusti, Irene
Achilli, Pietro
Bertoglio, Camillo Leonardo
Magistro, Carmelo
Ferrari, Giovanni
author_facet Mazzola, Michele
Ripamonti, Lorenzo
Giani, Alessandro
Carnevali, Pietro
Origi, Matteo
Alampi, BrunocDomenico
Giusti, Irene
Achilli, Pietro
Bertoglio, Camillo Leonardo
Magistro, Carmelo
Ferrari, Giovanni
author_sort Mazzola, Michele
collection PubMed
description Background: Despite its potential oncologic benefit, complete mesocolic excision (CME) has rarely been offered to elderly patients. The present study evaluated the effect of age on postoperative outcomes among patients undergoing laparoscopic right colectomies with CME for right-sided colon cancer (RCC). Methods: Data of patients undergoing laparoscopic right colectomies with CME for RCC between 2015 and 2018 were retrospectively analyzed. Selected patients were divided into two groups: the under-80 group and the over-80 group. Surgical, pathological, and oncological outcomes among the groups were compared. Results: A total of 130 patients were selected (95 in the under-80 group and 35 in the over-80 group). No difference was found between the groups in terms of postoperative outcomes, except for median length of stay and adjuvant chemotherapy received, which were in favor of the under-80 group (5 vs. 8 days, p < 0.001 and 26.3% vs. 2.9%, p = 0.003, respectively). No difference between the groups was found regarding overall survival and disease free survival. Using multivariate analysis, only the ASA score > 2 (p = 0.01) was an independent predictor of overall complications. Conclusions: laparoscopic right colectomy with CME for RCC was safely performed in elderly patients ensuring similar oncological outcomes compared to younger patients.
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spelling pubmed-102173062023-05-27 Should Laparoscopic Complete Mesocolic Excision Be Offered to Elderly Patients to Treat Right-Sided Colon Cancer? Mazzola, Michele Ripamonti, Lorenzo Giani, Alessandro Carnevali, Pietro Origi, Matteo Alampi, BrunocDomenico Giusti, Irene Achilli, Pietro Bertoglio, Camillo Leonardo Magistro, Carmelo Ferrari, Giovanni Curr Oncol Article Background: Despite its potential oncologic benefit, complete mesocolic excision (CME) has rarely been offered to elderly patients. The present study evaluated the effect of age on postoperative outcomes among patients undergoing laparoscopic right colectomies with CME for right-sided colon cancer (RCC). Methods: Data of patients undergoing laparoscopic right colectomies with CME for RCC between 2015 and 2018 were retrospectively analyzed. Selected patients were divided into two groups: the under-80 group and the over-80 group. Surgical, pathological, and oncological outcomes among the groups were compared. Results: A total of 130 patients were selected (95 in the under-80 group and 35 in the over-80 group). No difference was found between the groups in terms of postoperative outcomes, except for median length of stay and adjuvant chemotherapy received, which were in favor of the under-80 group (5 vs. 8 days, p < 0.001 and 26.3% vs. 2.9%, p = 0.003, respectively). No difference between the groups was found regarding overall survival and disease free survival. Using multivariate analysis, only the ASA score > 2 (p = 0.01) was an independent predictor of overall complications. Conclusions: laparoscopic right colectomy with CME for RCC was safely performed in elderly patients ensuring similar oncological outcomes compared to younger patients. MDPI 2023-05-13 /pmc/articles/PMC10217306/ /pubmed/37232834 http://dx.doi.org/10.3390/curroncol30050376 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Mazzola, Michele
Ripamonti, Lorenzo
Giani, Alessandro
Carnevali, Pietro
Origi, Matteo
Alampi, BrunocDomenico
Giusti, Irene
Achilli, Pietro
Bertoglio, Camillo Leonardo
Magistro, Carmelo
Ferrari, Giovanni
Should Laparoscopic Complete Mesocolic Excision Be Offered to Elderly Patients to Treat Right-Sided Colon Cancer?
title Should Laparoscopic Complete Mesocolic Excision Be Offered to Elderly Patients to Treat Right-Sided Colon Cancer?
title_full Should Laparoscopic Complete Mesocolic Excision Be Offered to Elderly Patients to Treat Right-Sided Colon Cancer?
title_fullStr Should Laparoscopic Complete Mesocolic Excision Be Offered to Elderly Patients to Treat Right-Sided Colon Cancer?
title_full_unstemmed Should Laparoscopic Complete Mesocolic Excision Be Offered to Elderly Patients to Treat Right-Sided Colon Cancer?
title_short Should Laparoscopic Complete Mesocolic Excision Be Offered to Elderly Patients to Treat Right-Sided Colon Cancer?
title_sort should laparoscopic complete mesocolic excision be offered to elderly patients to treat right-sided colon cancer?
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10217306/
https://www.ncbi.nlm.nih.gov/pubmed/37232834
http://dx.doi.org/10.3390/curroncol30050376
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