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Neonatal Outcomes of Term Infants Born with Meconium-Stained Amniotic Fluid

Background Meconium-stained amniotic fluid (MSAF) is considered an alarming sign of possible fetal compromise and it has recently been reported that neonatal outcome correlates with the degree of meconium thickness. Methods We retrospectively studied 400 term infants allocated in clear amniotic flui...

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Autores principales: Dani, Carlo, Ciarcià, Martina, Barone, Vittoria, Di Tommaso, Mariarosaria, Mecacci, Federico, Pasquini, Lucia, Pratesi, Simone
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10217366/
https://www.ncbi.nlm.nih.gov/pubmed/37238328
http://dx.doi.org/10.3390/children10050780
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author Dani, Carlo
Ciarcià, Martina
Barone, Vittoria
Di Tommaso, Mariarosaria
Mecacci, Federico
Pasquini, Lucia
Pratesi, Simone
author_facet Dani, Carlo
Ciarcià, Martina
Barone, Vittoria
Di Tommaso, Mariarosaria
Mecacci, Federico
Pasquini, Lucia
Pratesi, Simone
author_sort Dani, Carlo
collection PubMed
description Background Meconium-stained amniotic fluid (MSAF) is considered an alarming sign of possible fetal compromise and it has recently been reported that neonatal outcome correlates with the degree of meconium thickness. Methods We retrospectively studied 400 term infants allocated in clear amniotic fluid and grade 1, 2, and 3 MSAF groups on the basis of color and thickness of AF. Multivariable logistic regression analysis was performed to evaluate the potential independent effect of delivery with MSAF of different severity on the risk of a composite adverse neonatal outcome. Results We found that delivery with grade 2 (OR 16.82, 95% Cl 2.12–33.52; p = 0.008) and 3 (OR 33.79, 95% Cl 4.24–69.33; p < 0.001) MSAF is independently correlated with the risk of adverse neonatal outcome, such as the occurrence of at least one of the following: need of resuscitation in the delivery room, blood cord pH < 7.100, occurrence of meconium aspiration syndrome (MAS), persistent pulmonary hypertension (PPH), transient tachypnea of the newborn (TTN), acute respiratory distress syndrome (ARDS), hypoxic-ischemic encephalopathy (HIE), and sepsis. Conclusions There is a positive correlation between the severity of amniotic fluid meconium staining and thickness and the outcomes of term infants. Therefore, the evaluation and grading of MSAF during labor is useful in order to plan for the presence of a neonatologist at delivery for immediate and proper neonatal care.
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spelling pubmed-102173662023-05-27 Neonatal Outcomes of Term Infants Born with Meconium-Stained Amniotic Fluid Dani, Carlo Ciarcià, Martina Barone, Vittoria Di Tommaso, Mariarosaria Mecacci, Federico Pasquini, Lucia Pratesi, Simone Children (Basel) Article Background Meconium-stained amniotic fluid (MSAF) is considered an alarming sign of possible fetal compromise and it has recently been reported that neonatal outcome correlates with the degree of meconium thickness. Methods We retrospectively studied 400 term infants allocated in clear amniotic fluid and grade 1, 2, and 3 MSAF groups on the basis of color and thickness of AF. Multivariable logistic regression analysis was performed to evaluate the potential independent effect of delivery with MSAF of different severity on the risk of a composite adverse neonatal outcome. Results We found that delivery with grade 2 (OR 16.82, 95% Cl 2.12–33.52; p = 0.008) and 3 (OR 33.79, 95% Cl 4.24–69.33; p < 0.001) MSAF is independently correlated with the risk of adverse neonatal outcome, such as the occurrence of at least one of the following: need of resuscitation in the delivery room, blood cord pH < 7.100, occurrence of meconium aspiration syndrome (MAS), persistent pulmonary hypertension (PPH), transient tachypnea of the newborn (TTN), acute respiratory distress syndrome (ARDS), hypoxic-ischemic encephalopathy (HIE), and sepsis. Conclusions There is a positive correlation between the severity of amniotic fluid meconium staining and thickness and the outcomes of term infants. Therefore, the evaluation and grading of MSAF during labor is useful in order to plan for the presence of a neonatologist at delivery for immediate and proper neonatal care. MDPI 2023-04-26 /pmc/articles/PMC10217366/ /pubmed/37238328 http://dx.doi.org/10.3390/children10050780 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Dani, Carlo
Ciarcià, Martina
Barone, Vittoria
Di Tommaso, Mariarosaria
Mecacci, Federico
Pasquini, Lucia
Pratesi, Simone
Neonatal Outcomes of Term Infants Born with Meconium-Stained Amniotic Fluid
title Neonatal Outcomes of Term Infants Born with Meconium-Stained Amniotic Fluid
title_full Neonatal Outcomes of Term Infants Born with Meconium-Stained Amniotic Fluid
title_fullStr Neonatal Outcomes of Term Infants Born with Meconium-Stained Amniotic Fluid
title_full_unstemmed Neonatal Outcomes of Term Infants Born with Meconium-Stained Amniotic Fluid
title_short Neonatal Outcomes of Term Infants Born with Meconium-Stained Amniotic Fluid
title_sort neonatal outcomes of term infants born with meconium-stained amniotic fluid
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10217366/
https://www.ncbi.nlm.nih.gov/pubmed/37238328
http://dx.doi.org/10.3390/children10050780
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