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Giant Benign Struma Ovarii with High-Grade Fever, Elevated CA 125, and Hormonal Function in an Adolescent Patient

Struma ovarii (SO) is a monodermal teratoma containing at least 50% thyroid tissue. Classically, SO is a hormonally inactive benign neoplasm that occurs in premenopausal women, and has unspecific clinical and imaging features. Its treatment is surgical and its diagnosis is established histopathologi...

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Autores principales: Stefanopol, Ioana Anca, Petecariu, Alexandru, Baroiu, Liliana, Neagu, Anca-Iulia, Bogdan-Goroftei, Roxana-Elena, Nechifor, Alexandru, Ciortea, Diana-Andreea, Sarbu, Nicolae
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10217392/
https://www.ncbi.nlm.nih.gov/pubmed/37238404
http://dx.doi.org/10.3390/children10050856
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author Stefanopol, Ioana Anca
Petecariu, Alexandru
Baroiu, Liliana
Neagu, Anca-Iulia
Bogdan-Goroftei, Roxana-Elena
Nechifor, Alexandru
Ciortea, Diana-Andreea
Sarbu, Nicolae
author_facet Stefanopol, Ioana Anca
Petecariu, Alexandru
Baroiu, Liliana
Neagu, Anca-Iulia
Bogdan-Goroftei, Roxana-Elena
Nechifor, Alexandru
Ciortea, Diana-Andreea
Sarbu, Nicolae
author_sort Stefanopol, Ioana Anca
collection PubMed
description Struma ovarii (SO) is a monodermal teratoma containing at least 50% thyroid tissue. Classically, SO is a hormonally inactive benign neoplasm that occurs in premenopausal women, and has unspecific clinical and imaging features. Its treatment is surgical and its diagnosis is established histopathologically. We report the case of a euthyroid 16-year-old girl presenting with abdominal girth increase. An abdomino-pelvic ultrasound showed a giant multicystic mass with transonic content and multiple septa, and magnetic resonance imaging suggested the diagnosis of right ovarian mucinous cystadenoma. Blood tests showed inflammatory syndrome, iron deficiency anemia, mild hepatocytolysis, and elevated serum CA 125 levels. High-grade fever occurred on the third day of hospitalization, but none of the preoperative tests could identify its origin. Cystectomy was performed, and the histopathological examination revealed benign SO with a few small cysts with purulent content. The patient developed hypothyroidism postoperatively. In conclusion, this case report reunites most of the uncommon features of SO and confirms the superiorityof histopathology in its definitive diagnosis, as well as the suitability of ovarian sparing techniques, as the best treatment option for cystic ovarian pathology in pediatric patients, even in cases of large tumoral size and elevated serum CA 125 levels.
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spelling pubmed-102173922023-05-27 Giant Benign Struma Ovarii with High-Grade Fever, Elevated CA 125, and Hormonal Function in an Adolescent Patient Stefanopol, Ioana Anca Petecariu, Alexandru Baroiu, Liliana Neagu, Anca-Iulia Bogdan-Goroftei, Roxana-Elena Nechifor, Alexandru Ciortea, Diana-Andreea Sarbu, Nicolae Children (Basel) Case Report Struma ovarii (SO) is a monodermal teratoma containing at least 50% thyroid tissue. Classically, SO is a hormonally inactive benign neoplasm that occurs in premenopausal women, and has unspecific clinical and imaging features. Its treatment is surgical and its diagnosis is established histopathologically. We report the case of a euthyroid 16-year-old girl presenting with abdominal girth increase. An abdomino-pelvic ultrasound showed a giant multicystic mass with transonic content and multiple septa, and magnetic resonance imaging suggested the diagnosis of right ovarian mucinous cystadenoma. Blood tests showed inflammatory syndrome, iron deficiency anemia, mild hepatocytolysis, and elevated serum CA 125 levels. High-grade fever occurred on the third day of hospitalization, but none of the preoperative tests could identify its origin. Cystectomy was performed, and the histopathological examination revealed benign SO with a few small cysts with purulent content. The patient developed hypothyroidism postoperatively. In conclusion, this case report reunites most of the uncommon features of SO and confirms the superiorityof histopathology in its definitive diagnosis, as well as the suitability of ovarian sparing techniques, as the best treatment option for cystic ovarian pathology in pediatric patients, even in cases of large tumoral size and elevated serum CA 125 levels. MDPI 2023-05-11 /pmc/articles/PMC10217392/ /pubmed/37238404 http://dx.doi.org/10.3390/children10050856 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Stefanopol, Ioana Anca
Petecariu, Alexandru
Baroiu, Liliana
Neagu, Anca-Iulia
Bogdan-Goroftei, Roxana-Elena
Nechifor, Alexandru
Ciortea, Diana-Andreea
Sarbu, Nicolae
Giant Benign Struma Ovarii with High-Grade Fever, Elevated CA 125, and Hormonal Function in an Adolescent Patient
title Giant Benign Struma Ovarii with High-Grade Fever, Elevated CA 125, and Hormonal Function in an Adolescent Patient
title_full Giant Benign Struma Ovarii with High-Grade Fever, Elevated CA 125, and Hormonal Function in an Adolescent Patient
title_fullStr Giant Benign Struma Ovarii with High-Grade Fever, Elevated CA 125, and Hormonal Function in an Adolescent Patient
title_full_unstemmed Giant Benign Struma Ovarii with High-Grade Fever, Elevated CA 125, and Hormonal Function in an Adolescent Patient
title_short Giant Benign Struma Ovarii with High-Grade Fever, Elevated CA 125, and Hormonal Function in an Adolescent Patient
title_sort giant benign struma ovarii with high-grade fever, elevated ca 125, and hormonal function in an adolescent patient
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10217392/
https://www.ncbi.nlm.nih.gov/pubmed/37238404
http://dx.doi.org/10.3390/children10050856
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