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Imaging of Tauopathies with PET Ligands: State of the Art and Future Outlook

(1) Background: Tauopathies are a group of diseases characterized by the deposition of abnormal tau protein. They are distinguished into 3R, 4R, and 3R/4R tauopathies and also include Alzheimer’s disease (AD) and chronic traumatic encephalopathy (CTE). Positron emission tomography (PET) imaging repr...

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Autores principales: Conte, Miriam, De Feo, Maria Silvia, Sidrak, Marko Magdi Abdou, Corica, Ferdinando, Gorica, Joana, Granese, Giorgia Maria, Filippi, Luca, De Vincentis, Giuseppe, Frantellizzi, Viviana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10217406/
https://www.ncbi.nlm.nih.gov/pubmed/37238166
http://dx.doi.org/10.3390/diagnostics13101682
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author Conte, Miriam
De Feo, Maria Silvia
Sidrak, Marko Magdi Abdou
Corica, Ferdinando
Gorica, Joana
Granese, Giorgia Maria
Filippi, Luca
De Vincentis, Giuseppe
Frantellizzi, Viviana
author_facet Conte, Miriam
De Feo, Maria Silvia
Sidrak, Marko Magdi Abdou
Corica, Ferdinando
Gorica, Joana
Granese, Giorgia Maria
Filippi, Luca
De Vincentis, Giuseppe
Frantellizzi, Viviana
author_sort Conte, Miriam
collection PubMed
description (1) Background: Tauopathies are a group of diseases characterized by the deposition of abnormal tau protein. They are distinguished into 3R, 4R, and 3R/4R tauopathies and also include Alzheimer’s disease (AD) and chronic traumatic encephalopathy (CTE). Positron emission tomography (PET) imaging represents a pivotal instrument to guide clinicians. This systematic review aims to summarize the current and novel PET tracers. (2) Methods: Literature research was conducted on Pubmed, Scopus, Medline, Central, and the Web of Science using the query “pet ligands” and “tauopathies”. Articles published from January 2018 to 9 February, 2023, were searched. Only studies on the development of novel PET radiotracers for imaging in tauopathies or comparative studies between existing PET tracers were included. (3) Results: A total of 126 articles were found, as follows: 96 were identified from PubMed, 27 from Scopus, one on Central, two on Medline, and zero on the Web of Science. Twenty-four duplicated works were excluded, and 63 articles did not satisfy the inclusion criteria. The remaining 40 articles were included for quality assessment. (4) Conclusions: PET imaging represents a valid instrument capable of helping clinicians in diagnosis, but it is not always perfect in differential diagnosis, even if further investigations on humans for novel promising ligands are needed.
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spelling pubmed-102174062023-05-27 Imaging of Tauopathies with PET Ligands: State of the Art and Future Outlook Conte, Miriam De Feo, Maria Silvia Sidrak, Marko Magdi Abdou Corica, Ferdinando Gorica, Joana Granese, Giorgia Maria Filippi, Luca De Vincentis, Giuseppe Frantellizzi, Viviana Diagnostics (Basel) Review (1) Background: Tauopathies are a group of diseases characterized by the deposition of abnormal tau protein. They are distinguished into 3R, 4R, and 3R/4R tauopathies and also include Alzheimer’s disease (AD) and chronic traumatic encephalopathy (CTE). Positron emission tomography (PET) imaging represents a pivotal instrument to guide clinicians. This systematic review aims to summarize the current and novel PET tracers. (2) Methods: Literature research was conducted on Pubmed, Scopus, Medline, Central, and the Web of Science using the query “pet ligands” and “tauopathies”. Articles published from January 2018 to 9 February, 2023, were searched. Only studies on the development of novel PET radiotracers for imaging in tauopathies or comparative studies between existing PET tracers were included. (3) Results: A total of 126 articles were found, as follows: 96 were identified from PubMed, 27 from Scopus, one on Central, two on Medline, and zero on the Web of Science. Twenty-four duplicated works were excluded, and 63 articles did not satisfy the inclusion criteria. The remaining 40 articles were included for quality assessment. (4) Conclusions: PET imaging represents a valid instrument capable of helping clinicians in diagnosis, but it is not always perfect in differential diagnosis, even if further investigations on humans for novel promising ligands are needed. MDPI 2023-05-09 /pmc/articles/PMC10217406/ /pubmed/37238166 http://dx.doi.org/10.3390/diagnostics13101682 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Conte, Miriam
De Feo, Maria Silvia
Sidrak, Marko Magdi Abdou
Corica, Ferdinando
Gorica, Joana
Granese, Giorgia Maria
Filippi, Luca
De Vincentis, Giuseppe
Frantellizzi, Viviana
Imaging of Tauopathies with PET Ligands: State of the Art and Future Outlook
title Imaging of Tauopathies with PET Ligands: State of the Art and Future Outlook
title_full Imaging of Tauopathies with PET Ligands: State of the Art and Future Outlook
title_fullStr Imaging of Tauopathies with PET Ligands: State of the Art and Future Outlook
title_full_unstemmed Imaging of Tauopathies with PET Ligands: State of the Art and Future Outlook
title_short Imaging of Tauopathies with PET Ligands: State of the Art and Future Outlook
title_sort imaging of tauopathies with pet ligands: state of the art and future outlook
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10217406/
https://www.ncbi.nlm.nih.gov/pubmed/37238166
http://dx.doi.org/10.3390/diagnostics13101682
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