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CNS Border-Associated Macrophages: Ontogeny and Potential Implication in Disease
Being immune privileged, the central nervous system (CNS) is constituted by unique parenchymal and non-parenchymal tissue-resident macrophages, namely, microglia and border-associated macrophages (BAMs), respectively. BAMs are found in the choroid plexus, meningeal and perivascular spaces, playing c...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10217436/ https://www.ncbi.nlm.nih.gov/pubmed/37232741 http://dx.doi.org/10.3390/cimb45050272 |
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author | Dermitzakis, Iasonas Theotokis, Paschalis Evangelidis, Paschalis Delilampou, Efthymia Evangelidis, Nikolaos Chatzisavvidou, Anastasia Avramidou, Eleni Manthou, Maria Eleni |
author_facet | Dermitzakis, Iasonas Theotokis, Paschalis Evangelidis, Paschalis Delilampou, Efthymia Evangelidis, Nikolaos Chatzisavvidou, Anastasia Avramidou, Eleni Manthou, Maria Eleni |
author_sort | Dermitzakis, Iasonas |
collection | PubMed |
description | Being immune privileged, the central nervous system (CNS) is constituted by unique parenchymal and non-parenchymal tissue-resident macrophages, namely, microglia and border-associated macrophages (BAMs), respectively. BAMs are found in the choroid plexus, meningeal and perivascular spaces, playing critical roles in maintaining CNS homeostasis while being phenotypically and functionally distinct from microglial cells. Although the ontogeny of microglia has been largely determined, BAMs need comparable scrutiny as they have been recently discovered and have not been thoroughly explored. Newly developed techniques have transformed our understanding of BAMs, revealing their cellular heterogeneity and diversity. Recent data showed that BAMs also originate from yolk sac progenitors instead of bone marrow-derived monocytes, highlighting the absolute need to further investigate their repopulation pattern in adult CNS. Shedding light on the molecular cues and drivers orchestrating BAM generation is essential for delineating their cellular identity. BAMs are receiving more attention since they are gradually incorporated into neurodegenerative and neuroinflammatory disease evaluations. The present review provides insights towards the current understanding regarding the ontogeny of BAMs and their involvement in CNS diseases, paving their way into targeted therapeutic strategies and precision medicine. |
format | Online Article Text |
id | pubmed-10217436 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-102174362023-05-27 CNS Border-Associated Macrophages: Ontogeny and Potential Implication in Disease Dermitzakis, Iasonas Theotokis, Paschalis Evangelidis, Paschalis Delilampou, Efthymia Evangelidis, Nikolaos Chatzisavvidou, Anastasia Avramidou, Eleni Manthou, Maria Eleni Curr Issues Mol Biol Review Being immune privileged, the central nervous system (CNS) is constituted by unique parenchymal and non-parenchymal tissue-resident macrophages, namely, microglia and border-associated macrophages (BAMs), respectively. BAMs are found in the choroid plexus, meningeal and perivascular spaces, playing critical roles in maintaining CNS homeostasis while being phenotypically and functionally distinct from microglial cells. Although the ontogeny of microglia has been largely determined, BAMs need comparable scrutiny as they have been recently discovered and have not been thoroughly explored. Newly developed techniques have transformed our understanding of BAMs, revealing their cellular heterogeneity and diversity. Recent data showed that BAMs also originate from yolk sac progenitors instead of bone marrow-derived monocytes, highlighting the absolute need to further investigate their repopulation pattern in adult CNS. Shedding light on the molecular cues and drivers orchestrating BAM generation is essential for delineating their cellular identity. BAMs are receiving more attention since they are gradually incorporated into neurodegenerative and neuroinflammatory disease evaluations. The present review provides insights towards the current understanding regarding the ontogeny of BAMs and their involvement in CNS diseases, paving their way into targeted therapeutic strategies and precision medicine. MDPI 2023-05-13 /pmc/articles/PMC10217436/ /pubmed/37232741 http://dx.doi.org/10.3390/cimb45050272 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Dermitzakis, Iasonas Theotokis, Paschalis Evangelidis, Paschalis Delilampou, Efthymia Evangelidis, Nikolaos Chatzisavvidou, Anastasia Avramidou, Eleni Manthou, Maria Eleni CNS Border-Associated Macrophages: Ontogeny and Potential Implication in Disease |
title | CNS Border-Associated Macrophages: Ontogeny and Potential Implication in Disease |
title_full | CNS Border-Associated Macrophages: Ontogeny and Potential Implication in Disease |
title_fullStr | CNS Border-Associated Macrophages: Ontogeny and Potential Implication in Disease |
title_full_unstemmed | CNS Border-Associated Macrophages: Ontogeny and Potential Implication in Disease |
title_short | CNS Border-Associated Macrophages: Ontogeny and Potential Implication in Disease |
title_sort | cns border-associated macrophages: ontogeny and potential implication in disease |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10217436/ https://www.ncbi.nlm.nih.gov/pubmed/37232741 http://dx.doi.org/10.3390/cimb45050272 |
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