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Current Insights into the Significance of the Renal Resistive Index in Kidney and Cardiovascular Disease

Initially, the renal resistive index (RRI) was investigated with the aim of improving diagnosis in kidney diseases, but this goal was not met. Recently, many papers have highlighted the prognostic significance of the RRI in chronic kidney disease: specifically, in estimating the revascularization su...

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Autores principales: Darabont, Roxana, Mihalcea, Diana, Vinereanu, Dragos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10217442/
https://www.ncbi.nlm.nih.gov/pubmed/37238172
http://dx.doi.org/10.3390/diagnostics13101687
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author Darabont, Roxana
Mihalcea, Diana
Vinereanu, Dragos
author_facet Darabont, Roxana
Mihalcea, Diana
Vinereanu, Dragos
author_sort Darabont, Roxana
collection PubMed
description Initially, the renal resistive index (RRI) was investigated with the aim of improving diagnosis in kidney diseases, but this goal was not met. Recently, many papers have highlighted the prognostic significance of the RRI in chronic kidney disease: specifically, in estimating the revascularization success of renal artery stenoses or the evolution of the graft and the recipients in renal transplantation. Moreover, the RRI has become significant in the prediction of acute kidney injury in critically ill patients. Studies in renal pathology have revealed correlations of this index with parameters of systemic circulation. The theoretical and experimental premises of this connection were then reconsidered, and studies analyzing the link between RRI and arterial stiffness, central and peripheral pressure, and left ventricular flow were conducted with this purpose. Many data currently indicate that RRI is influenced more by pulse pressure and vascular compliance than by renal vascular resistance—assuming that RRI reflects the complex interplay between systemic circulation and renal microcirculation and should be considered a marker of systemic cardiovascular risk beyond its prognostic relevance for kidney disease. In this review, we overview the clinical research that reveals the implications of RRI in renal and cardiovascular disease.
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spelling pubmed-102174422023-05-27 Current Insights into the Significance of the Renal Resistive Index in Kidney and Cardiovascular Disease Darabont, Roxana Mihalcea, Diana Vinereanu, Dragos Diagnostics (Basel) Review Initially, the renal resistive index (RRI) was investigated with the aim of improving diagnosis in kidney diseases, but this goal was not met. Recently, many papers have highlighted the prognostic significance of the RRI in chronic kidney disease: specifically, in estimating the revascularization success of renal artery stenoses or the evolution of the graft and the recipients in renal transplantation. Moreover, the RRI has become significant in the prediction of acute kidney injury in critically ill patients. Studies in renal pathology have revealed correlations of this index with parameters of systemic circulation. The theoretical and experimental premises of this connection were then reconsidered, and studies analyzing the link between RRI and arterial stiffness, central and peripheral pressure, and left ventricular flow were conducted with this purpose. Many data currently indicate that RRI is influenced more by pulse pressure and vascular compliance than by renal vascular resistance—assuming that RRI reflects the complex interplay between systemic circulation and renal microcirculation and should be considered a marker of systemic cardiovascular risk beyond its prognostic relevance for kidney disease. In this review, we overview the clinical research that reveals the implications of RRI in renal and cardiovascular disease. MDPI 2023-05-10 /pmc/articles/PMC10217442/ /pubmed/37238172 http://dx.doi.org/10.3390/diagnostics13101687 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Darabont, Roxana
Mihalcea, Diana
Vinereanu, Dragos
Current Insights into the Significance of the Renal Resistive Index in Kidney and Cardiovascular Disease
title Current Insights into the Significance of the Renal Resistive Index in Kidney and Cardiovascular Disease
title_full Current Insights into the Significance of the Renal Resistive Index in Kidney and Cardiovascular Disease
title_fullStr Current Insights into the Significance of the Renal Resistive Index in Kidney and Cardiovascular Disease
title_full_unstemmed Current Insights into the Significance of the Renal Resistive Index in Kidney and Cardiovascular Disease
title_short Current Insights into the Significance of the Renal Resistive Index in Kidney and Cardiovascular Disease
title_sort current insights into the significance of the renal resistive index in kidney and cardiovascular disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10217442/
https://www.ncbi.nlm.nih.gov/pubmed/37238172
http://dx.doi.org/10.3390/diagnostics13101687
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