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Electrochemical Creatinine (Bio)Sensors for Point-of-Care Diagnosis of Renal Malfunction and Chronic Kidney Disorders

In the post-pandemic era, point-of-care (POC) diagnosis of diseases is an important research frontier. Modern portable electrochemical (bio)sensors enable the design of POC diagnostics for the identification of diseases and regular healthcare monitoring. Herein, we present a critical review of the e...

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Autores principales: Saddique, Zohaib, Faheem, Muhammad, Habib, Amir, UlHasan, Iftikhar, Mujahid, Adnan, Afzal, Adeel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10217452/
https://www.ncbi.nlm.nih.gov/pubmed/37238220
http://dx.doi.org/10.3390/diagnostics13101737
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author Saddique, Zohaib
Faheem, Muhammad
Habib, Amir
UlHasan, Iftikhar
Mujahid, Adnan
Afzal, Adeel
author_facet Saddique, Zohaib
Faheem, Muhammad
Habib, Amir
UlHasan, Iftikhar
Mujahid, Adnan
Afzal, Adeel
author_sort Saddique, Zohaib
collection PubMed
description In the post-pandemic era, point-of-care (POC) diagnosis of diseases is an important research frontier. Modern portable electrochemical (bio)sensors enable the design of POC diagnostics for the identification of diseases and regular healthcare monitoring. Herein, we present a critical review of the electrochemical creatinine (bio)sensors. These sensors either make use of biological receptors such as enzymes or employ synthetic responsive materials, which provide a sensitive interface for creatinine-specific interactions. The characteristics of different receptors and electrochemical devices are discussed, along with their limitations. The major challenges in the development of affordable and deliverable creatinine diagnostics and the drawbacks of enzymatic and enzymeless electrochemical biosensors are elaborated, especially considering their analytical performance parameters. These revolutionary devices have potential biomedical applications ranging from early POC diagnosis of chronic kidney disease (CKD) and other kidney-related illnesses to routine monitoring of creatinine in elderly and at-risk humans.
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spelling pubmed-102174522023-05-27 Electrochemical Creatinine (Bio)Sensors for Point-of-Care Diagnosis of Renal Malfunction and Chronic Kidney Disorders Saddique, Zohaib Faheem, Muhammad Habib, Amir UlHasan, Iftikhar Mujahid, Adnan Afzal, Adeel Diagnostics (Basel) Review In the post-pandemic era, point-of-care (POC) diagnosis of diseases is an important research frontier. Modern portable electrochemical (bio)sensors enable the design of POC diagnostics for the identification of diseases and regular healthcare monitoring. Herein, we present a critical review of the electrochemical creatinine (bio)sensors. These sensors either make use of biological receptors such as enzymes or employ synthetic responsive materials, which provide a sensitive interface for creatinine-specific interactions. The characteristics of different receptors and electrochemical devices are discussed, along with their limitations. The major challenges in the development of affordable and deliverable creatinine diagnostics and the drawbacks of enzymatic and enzymeless electrochemical biosensors are elaborated, especially considering their analytical performance parameters. These revolutionary devices have potential biomedical applications ranging from early POC diagnosis of chronic kidney disease (CKD) and other kidney-related illnesses to routine monitoring of creatinine in elderly and at-risk humans. MDPI 2023-05-13 /pmc/articles/PMC10217452/ /pubmed/37238220 http://dx.doi.org/10.3390/diagnostics13101737 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Saddique, Zohaib
Faheem, Muhammad
Habib, Amir
UlHasan, Iftikhar
Mujahid, Adnan
Afzal, Adeel
Electrochemical Creatinine (Bio)Sensors for Point-of-Care Diagnosis of Renal Malfunction and Chronic Kidney Disorders
title Electrochemical Creatinine (Bio)Sensors for Point-of-Care Diagnosis of Renal Malfunction and Chronic Kidney Disorders
title_full Electrochemical Creatinine (Bio)Sensors for Point-of-Care Diagnosis of Renal Malfunction and Chronic Kidney Disorders
title_fullStr Electrochemical Creatinine (Bio)Sensors for Point-of-Care Diagnosis of Renal Malfunction and Chronic Kidney Disorders
title_full_unstemmed Electrochemical Creatinine (Bio)Sensors for Point-of-Care Diagnosis of Renal Malfunction and Chronic Kidney Disorders
title_short Electrochemical Creatinine (Bio)Sensors for Point-of-Care Diagnosis of Renal Malfunction and Chronic Kidney Disorders
title_sort electrochemical creatinine (bio)sensors for point-of-care diagnosis of renal malfunction and chronic kidney disorders
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10217452/
https://www.ncbi.nlm.nih.gov/pubmed/37238220
http://dx.doi.org/10.3390/diagnostics13101737
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