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High TLR6 Expression Status Predicts a More Favorable Prognosis after Esophagectomy for Locally Advanced Thoracic Esophageal Squamous Cell Carcinoma
Most so-called “beneficial bacteria” in gut microbiota are Gram-positive, and TLR6 recognizes the peptidoglycan (PGN) present in their cell walls. We hypothesized that a high TLR6 expression status predicts a more favorable prognosis after esophagectomy. We used an ESCC tissue microarray (TMA) to ex...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10217459/ https://www.ncbi.nlm.nih.gov/pubmed/37232814 http://dx.doi.org/10.3390/curroncol30050356 |
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author | Sato, Yusuke Wakita, Akiyuki Maeda, Eri Nagaki, Yushi Sasamori, Ryohei Kemuriyama, Kohei Nozaki, Shu Ito, Satoru Terata, Kaori Imai, Kazuhiro Nanjo, Hiroshi Nomura, Kyoko Minamiya, Yoshihiro |
author_facet | Sato, Yusuke Wakita, Akiyuki Maeda, Eri Nagaki, Yushi Sasamori, Ryohei Kemuriyama, Kohei Nozaki, Shu Ito, Satoru Terata, Kaori Imai, Kazuhiro Nanjo, Hiroshi Nomura, Kyoko Minamiya, Yoshihiro |
author_sort | Sato, Yusuke |
collection | PubMed |
description | Most so-called “beneficial bacteria” in gut microbiota are Gram-positive, and TLR6 recognizes the peptidoglycan (PGN) present in their cell walls. We hypothesized that a high TLR6 expression status predicts a more favorable prognosis after esophagectomy. We used an ESCC tissue microarray (TMA) to examine TLR6 expression status in ESCC patients and to determine whether TLR6 expression status correlates with prognosis after curative esophagectomy. We also examined whether PGN influences the cell proliferation activity of ESCC lines. Clinical ESCC samples from 177 patients tested for the expression of TLR6 were categorized as 3+ (n = 17), 2+ (n = 48), 1+ (n = 68), or 0 (n = 44). High TLR6 expression (3+ and 2+) correlated with significantly more favorable 5-year overall survival (OS) and disease-specific survival (DSS) after esophagectomy than a lower TLR6 expression (1+ and 0). Univariate and multivariate analyses showed that TLR6 expression status is an independent prognostic factor that affects 5-year OS. PGN significantly inhibited the cell proliferation activity of ESCC lines. This is the first study to show that high TLR6 expression status predicts a more favorable prognosis in locally advanced thoracic ESCC patients after curative esophagectomy. PGN released from “beneficial bacteria” seems to have potential to inhibit the cell proliferation activity of ESCC. |
format | Online Article Text |
id | pubmed-10217459 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-102174592023-05-27 High TLR6 Expression Status Predicts a More Favorable Prognosis after Esophagectomy for Locally Advanced Thoracic Esophageal Squamous Cell Carcinoma Sato, Yusuke Wakita, Akiyuki Maeda, Eri Nagaki, Yushi Sasamori, Ryohei Kemuriyama, Kohei Nozaki, Shu Ito, Satoru Terata, Kaori Imai, Kazuhiro Nanjo, Hiroshi Nomura, Kyoko Minamiya, Yoshihiro Curr Oncol Article Most so-called “beneficial bacteria” in gut microbiota are Gram-positive, and TLR6 recognizes the peptidoglycan (PGN) present in their cell walls. We hypothesized that a high TLR6 expression status predicts a more favorable prognosis after esophagectomy. We used an ESCC tissue microarray (TMA) to examine TLR6 expression status in ESCC patients and to determine whether TLR6 expression status correlates with prognosis after curative esophagectomy. We also examined whether PGN influences the cell proliferation activity of ESCC lines. Clinical ESCC samples from 177 patients tested for the expression of TLR6 were categorized as 3+ (n = 17), 2+ (n = 48), 1+ (n = 68), or 0 (n = 44). High TLR6 expression (3+ and 2+) correlated with significantly more favorable 5-year overall survival (OS) and disease-specific survival (DSS) after esophagectomy than a lower TLR6 expression (1+ and 0). Univariate and multivariate analyses showed that TLR6 expression status is an independent prognostic factor that affects 5-year OS. PGN significantly inhibited the cell proliferation activity of ESCC lines. This is the first study to show that high TLR6 expression status predicts a more favorable prognosis in locally advanced thoracic ESCC patients after curative esophagectomy. PGN released from “beneficial bacteria” seems to have potential to inhibit the cell proliferation activity of ESCC. MDPI 2023-05-04 /pmc/articles/PMC10217459/ /pubmed/37232814 http://dx.doi.org/10.3390/curroncol30050356 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Sato, Yusuke Wakita, Akiyuki Maeda, Eri Nagaki, Yushi Sasamori, Ryohei Kemuriyama, Kohei Nozaki, Shu Ito, Satoru Terata, Kaori Imai, Kazuhiro Nanjo, Hiroshi Nomura, Kyoko Minamiya, Yoshihiro High TLR6 Expression Status Predicts a More Favorable Prognosis after Esophagectomy for Locally Advanced Thoracic Esophageal Squamous Cell Carcinoma |
title | High TLR6 Expression Status Predicts a More Favorable Prognosis after Esophagectomy for Locally Advanced Thoracic Esophageal Squamous Cell Carcinoma |
title_full | High TLR6 Expression Status Predicts a More Favorable Prognosis after Esophagectomy for Locally Advanced Thoracic Esophageal Squamous Cell Carcinoma |
title_fullStr | High TLR6 Expression Status Predicts a More Favorable Prognosis after Esophagectomy for Locally Advanced Thoracic Esophageal Squamous Cell Carcinoma |
title_full_unstemmed | High TLR6 Expression Status Predicts a More Favorable Prognosis after Esophagectomy for Locally Advanced Thoracic Esophageal Squamous Cell Carcinoma |
title_short | High TLR6 Expression Status Predicts a More Favorable Prognosis after Esophagectomy for Locally Advanced Thoracic Esophageal Squamous Cell Carcinoma |
title_sort | high tlr6 expression status predicts a more favorable prognosis after esophagectomy for locally advanced thoracic esophageal squamous cell carcinoma |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10217459/ https://www.ncbi.nlm.nih.gov/pubmed/37232814 http://dx.doi.org/10.3390/curroncol30050356 |
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