Mitochondrial Cholesterol Metabolites in a Bile Acid Synthetic Pathway Drive Nonalcoholic Fatty Liver Disease: A Revised “Two-Hit” Hypothesis

The rising prevalence of nonalcoholic fatty liver disease (NAFLD)-related cirrhosis highlights the need for a better understanding of the molecular mechanisms responsible for driving the transition of hepatic steatosis (fatty liver; NAFL) to steatohepatitis (NASH) and fibrosis/cirrhosis. Obesity-rel...

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Detalles Bibliográficos
Autores principales: Kakiyama, Genta, Rodriguez-Agudo, Daniel, Pandak, William M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10217489/
https://www.ncbi.nlm.nih.gov/pubmed/37408268
http://dx.doi.org/10.3390/cells12101434

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10217489/
https://www.ncbi.nlm.nih.gov/pubmed/37408268
http://dx.doi.org/10.3390/cells12101434

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