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Heart Failure Post-SARS-CoV-2 Infection in Children with Duchenne Muscular Dystrophy: The Additive Value of Cardiovascular Magnetic Resonance

In this case series, we describe the diagnosis of post-COVID-19 myocarditis in asymptomatic patients with Duchenne Muscular Dystrophy (DMD) and a mild COVID-19 disease course. These patients were referred for CMR due to electrocardiographic and echocardiographic alterations, which did not exist befo...

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Autores principales: Markousis-Mavrogenis, George, Belegrinos, Antonios, Giannakopoulou, Aikaterini, Karanasios, Evangelos, Vartela, Vasiliki, Patsilinakou, Elephtheria, Samantis, Paul, Pons, Roser-Marie, Papavasiliou, Antigoni, Mavrogeni, Sophie I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10217500/
https://www.ncbi.nlm.nih.gov/pubmed/37238442
http://dx.doi.org/10.3390/children10050894
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author Markousis-Mavrogenis, George
Belegrinos, Antonios
Giannakopoulou, Aikaterini
Karanasios, Evangelos
Vartela, Vasiliki
Patsilinakou, Elephtheria
Samantis, Paul
Pons, Roser-Marie
Papavasiliou, Antigoni
Mavrogeni, Sophie I.
author_facet Markousis-Mavrogenis, George
Belegrinos, Antonios
Giannakopoulou, Aikaterini
Karanasios, Evangelos
Vartela, Vasiliki
Patsilinakou, Elephtheria
Samantis, Paul
Pons, Roser-Marie
Papavasiliou, Antigoni
Mavrogeni, Sophie I.
author_sort Markousis-Mavrogenis, George
collection PubMed
description In this case series, we describe the diagnosis of post-COVID-19 myocarditis in asymptomatic patients with Duchenne Muscular Dystrophy (DMD) and a mild COVID-19 disease course. These patients were referred for CMR due to electrocardiographic and echocardiographic alterations, which did not exist before COVID-19 infection. CMR identified the presence of severe myocardial inflammation in all patients based on abnormally elevated myocardial T2 ratio, late gadolinium enhancement, native T1 mapping, T2 mapping, and extracellular volume fraction. This was paired with concurrent impairment of left ventricular function. Appropriate treatment was initiated in all cases. Two of the four patients developed episodes of ventricular tachycardia during the following 6 months, and a defibrillator was implanted. Despite the mild clinical presentation, this case series demonstrates the diagnostic strength of CMR in the diagnosis and evaluation of post-COVID-19 myocarditis and serves to increase awareness of this potential complication amongst treating physicians.
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spelling pubmed-102175002023-05-27 Heart Failure Post-SARS-CoV-2 Infection in Children with Duchenne Muscular Dystrophy: The Additive Value of Cardiovascular Magnetic Resonance Markousis-Mavrogenis, George Belegrinos, Antonios Giannakopoulou, Aikaterini Karanasios, Evangelos Vartela, Vasiliki Patsilinakou, Elephtheria Samantis, Paul Pons, Roser-Marie Papavasiliou, Antigoni Mavrogeni, Sophie I. Children (Basel) Case Report In this case series, we describe the diagnosis of post-COVID-19 myocarditis in asymptomatic patients with Duchenne Muscular Dystrophy (DMD) and a mild COVID-19 disease course. These patients were referred for CMR due to electrocardiographic and echocardiographic alterations, which did not exist before COVID-19 infection. CMR identified the presence of severe myocardial inflammation in all patients based on abnormally elevated myocardial T2 ratio, late gadolinium enhancement, native T1 mapping, T2 mapping, and extracellular volume fraction. This was paired with concurrent impairment of left ventricular function. Appropriate treatment was initiated in all cases. Two of the four patients developed episodes of ventricular tachycardia during the following 6 months, and a defibrillator was implanted. Despite the mild clinical presentation, this case series demonstrates the diagnostic strength of CMR in the diagnosis and evaluation of post-COVID-19 myocarditis and serves to increase awareness of this potential complication amongst treating physicians. MDPI 2023-05-17 /pmc/articles/PMC10217500/ /pubmed/37238442 http://dx.doi.org/10.3390/children10050894 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Markousis-Mavrogenis, George
Belegrinos, Antonios
Giannakopoulou, Aikaterini
Karanasios, Evangelos
Vartela, Vasiliki
Patsilinakou, Elephtheria
Samantis, Paul
Pons, Roser-Marie
Papavasiliou, Antigoni
Mavrogeni, Sophie I.
Heart Failure Post-SARS-CoV-2 Infection in Children with Duchenne Muscular Dystrophy: The Additive Value of Cardiovascular Magnetic Resonance
title Heart Failure Post-SARS-CoV-2 Infection in Children with Duchenne Muscular Dystrophy: The Additive Value of Cardiovascular Magnetic Resonance
title_full Heart Failure Post-SARS-CoV-2 Infection in Children with Duchenne Muscular Dystrophy: The Additive Value of Cardiovascular Magnetic Resonance
title_fullStr Heart Failure Post-SARS-CoV-2 Infection in Children with Duchenne Muscular Dystrophy: The Additive Value of Cardiovascular Magnetic Resonance
title_full_unstemmed Heart Failure Post-SARS-CoV-2 Infection in Children with Duchenne Muscular Dystrophy: The Additive Value of Cardiovascular Magnetic Resonance
title_short Heart Failure Post-SARS-CoV-2 Infection in Children with Duchenne Muscular Dystrophy: The Additive Value of Cardiovascular Magnetic Resonance
title_sort heart failure post-sars-cov-2 infection in children with duchenne muscular dystrophy: the additive value of cardiovascular magnetic resonance
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10217500/
https://www.ncbi.nlm.nih.gov/pubmed/37238442
http://dx.doi.org/10.3390/children10050894
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