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Heart Failure Post-SARS-CoV-2 Infection in Children with Duchenne Muscular Dystrophy: The Additive Value of Cardiovascular Magnetic Resonance
In this case series, we describe the diagnosis of post-COVID-19 myocarditis in asymptomatic patients with Duchenne Muscular Dystrophy (DMD) and a mild COVID-19 disease course. These patients were referred for CMR due to electrocardiographic and echocardiographic alterations, which did not exist befo...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10217500/ https://www.ncbi.nlm.nih.gov/pubmed/37238442 http://dx.doi.org/10.3390/children10050894 |
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author | Markousis-Mavrogenis, George Belegrinos, Antonios Giannakopoulou, Aikaterini Karanasios, Evangelos Vartela, Vasiliki Patsilinakou, Elephtheria Samantis, Paul Pons, Roser-Marie Papavasiliou, Antigoni Mavrogeni, Sophie I. |
author_facet | Markousis-Mavrogenis, George Belegrinos, Antonios Giannakopoulou, Aikaterini Karanasios, Evangelos Vartela, Vasiliki Patsilinakou, Elephtheria Samantis, Paul Pons, Roser-Marie Papavasiliou, Antigoni Mavrogeni, Sophie I. |
author_sort | Markousis-Mavrogenis, George |
collection | PubMed |
description | In this case series, we describe the diagnosis of post-COVID-19 myocarditis in asymptomatic patients with Duchenne Muscular Dystrophy (DMD) and a mild COVID-19 disease course. These patients were referred for CMR due to electrocardiographic and echocardiographic alterations, which did not exist before COVID-19 infection. CMR identified the presence of severe myocardial inflammation in all patients based on abnormally elevated myocardial T2 ratio, late gadolinium enhancement, native T1 mapping, T2 mapping, and extracellular volume fraction. This was paired with concurrent impairment of left ventricular function. Appropriate treatment was initiated in all cases. Two of the four patients developed episodes of ventricular tachycardia during the following 6 months, and a defibrillator was implanted. Despite the mild clinical presentation, this case series demonstrates the diagnostic strength of CMR in the diagnosis and evaluation of post-COVID-19 myocarditis and serves to increase awareness of this potential complication amongst treating physicians. |
format | Online Article Text |
id | pubmed-10217500 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-102175002023-05-27 Heart Failure Post-SARS-CoV-2 Infection in Children with Duchenne Muscular Dystrophy: The Additive Value of Cardiovascular Magnetic Resonance Markousis-Mavrogenis, George Belegrinos, Antonios Giannakopoulou, Aikaterini Karanasios, Evangelos Vartela, Vasiliki Patsilinakou, Elephtheria Samantis, Paul Pons, Roser-Marie Papavasiliou, Antigoni Mavrogeni, Sophie I. Children (Basel) Case Report In this case series, we describe the diagnosis of post-COVID-19 myocarditis in asymptomatic patients with Duchenne Muscular Dystrophy (DMD) and a mild COVID-19 disease course. These patients were referred for CMR due to electrocardiographic and echocardiographic alterations, which did not exist before COVID-19 infection. CMR identified the presence of severe myocardial inflammation in all patients based on abnormally elevated myocardial T2 ratio, late gadolinium enhancement, native T1 mapping, T2 mapping, and extracellular volume fraction. This was paired with concurrent impairment of left ventricular function. Appropriate treatment was initiated in all cases. Two of the four patients developed episodes of ventricular tachycardia during the following 6 months, and a defibrillator was implanted. Despite the mild clinical presentation, this case series demonstrates the diagnostic strength of CMR in the diagnosis and evaluation of post-COVID-19 myocarditis and serves to increase awareness of this potential complication amongst treating physicians. MDPI 2023-05-17 /pmc/articles/PMC10217500/ /pubmed/37238442 http://dx.doi.org/10.3390/children10050894 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Case Report Markousis-Mavrogenis, George Belegrinos, Antonios Giannakopoulou, Aikaterini Karanasios, Evangelos Vartela, Vasiliki Patsilinakou, Elephtheria Samantis, Paul Pons, Roser-Marie Papavasiliou, Antigoni Mavrogeni, Sophie I. Heart Failure Post-SARS-CoV-2 Infection in Children with Duchenne Muscular Dystrophy: The Additive Value of Cardiovascular Magnetic Resonance |
title | Heart Failure Post-SARS-CoV-2 Infection in Children with Duchenne Muscular Dystrophy: The Additive Value of Cardiovascular Magnetic Resonance |
title_full | Heart Failure Post-SARS-CoV-2 Infection in Children with Duchenne Muscular Dystrophy: The Additive Value of Cardiovascular Magnetic Resonance |
title_fullStr | Heart Failure Post-SARS-CoV-2 Infection in Children with Duchenne Muscular Dystrophy: The Additive Value of Cardiovascular Magnetic Resonance |
title_full_unstemmed | Heart Failure Post-SARS-CoV-2 Infection in Children with Duchenne Muscular Dystrophy: The Additive Value of Cardiovascular Magnetic Resonance |
title_short | Heart Failure Post-SARS-CoV-2 Infection in Children with Duchenne Muscular Dystrophy: The Additive Value of Cardiovascular Magnetic Resonance |
title_sort | heart failure post-sars-cov-2 infection in children with duchenne muscular dystrophy: the additive value of cardiovascular magnetic resonance |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10217500/ https://www.ncbi.nlm.nih.gov/pubmed/37238442 http://dx.doi.org/10.3390/children10050894 |
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