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An International Investigation of Molar Incisor Hypomineralisation (iMIH) and Its Association with Dental Anomalies: Development of a Protocol

Background: Molar incisor hypomineralisation (MIH) is a common disorder of tooth development, which has recently been found to be associated with a higher prevalence of hypodontia. The aim of this international multicentre study is to determine the association between MIH and other developmental ano...

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Autores principales: Rodd, Helen D., Nazzal, Hani, Bonifacio, Clarissa Calil, Ruth, Choe Wei, Crombie, Felicity, El Shahawy, Osama, Folayan, Morenike Oluwatoyin, Gambetta-Tessini, Karla, Goyal, Ashima, Hasmun, Noren, Issa, Ahmad I., Jundi, Suhad, Manton, David J., Narasimhan, Srinivasan, Omar, Samah, Parekh, Susan, Popoola, Bamidele O, Silva, Mihiri, Taylor, Greig, Naomi, Yang Qiyue
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10217515/
https://www.ncbi.nlm.nih.gov/pubmed/37232768
http://dx.doi.org/10.3390/dj11050117
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author Rodd, Helen D.
Nazzal, Hani
Bonifacio, Clarissa Calil
Ruth, Choe Wei
Crombie, Felicity
El Shahawy, Osama
Folayan, Morenike Oluwatoyin
Gambetta-Tessini, Karla
Goyal, Ashima
Hasmun, Noren
Issa, Ahmad I.
Jundi, Suhad
Manton, David J.
Narasimhan, Srinivasan
Omar, Samah
Parekh, Susan
Popoola, Bamidele O
Silva, Mihiri
Taylor, Greig
Naomi, Yang Qiyue
author_facet Rodd, Helen D.
Nazzal, Hani
Bonifacio, Clarissa Calil
Ruth, Choe Wei
Crombie, Felicity
El Shahawy, Osama
Folayan, Morenike Oluwatoyin
Gambetta-Tessini, Karla
Goyal, Ashima
Hasmun, Noren
Issa, Ahmad I.
Jundi, Suhad
Manton, David J.
Narasimhan, Srinivasan
Omar, Samah
Parekh, Susan
Popoola, Bamidele O
Silva, Mihiri
Taylor, Greig
Naomi, Yang Qiyue
author_sort Rodd, Helen D.
collection PubMed
description Background: Molar incisor hypomineralisation (MIH) is a common disorder of tooth development, which has recently been found to be associated with a higher prevalence of hypodontia. The aim of this international multicentre study is to determine the association between MIH and other developmental anomalies in different populations. Methods: Investigators were trained and calibrated for the assessment of MIH and dental anomalies and ethical approvals obtained in each participating country. The study aimed to recruit 584 children with MIH and 584 children without MIH. Patients aged 7–16 years who attend specialist clinics will be invited to participate. Children will undergo a clinical examination to determine the presence and severity of MIH, using an established index. The presence of any other anomalies, affecting tooth number, morphology, or position, will be documented. Panoramic radiographs will be assessed for dental anomalies and the presence of third permanent molars. Statistical analysis, using a chi squared test and regression analysis, will be performed to determine any differences in dental anomaly prevalence between the MIH and non-MIH group and to determine any association between dental anomalies and patient characteristics. Conclusion: This large-scale study has the potential to improve understanding about MIH with benefits for patient management.
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spelling pubmed-102175152023-05-27 An International Investigation of Molar Incisor Hypomineralisation (iMIH) and Its Association with Dental Anomalies: Development of a Protocol Rodd, Helen D. Nazzal, Hani Bonifacio, Clarissa Calil Ruth, Choe Wei Crombie, Felicity El Shahawy, Osama Folayan, Morenike Oluwatoyin Gambetta-Tessini, Karla Goyal, Ashima Hasmun, Noren Issa, Ahmad I. Jundi, Suhad Manton, David J. Narasimhan, Srinivasan Omar, Samah Parekh, Susan Popoola, Bamidele O Silva, Mihiri Taylor, Greig Naomi, Yang Qiyue Dent J (Basel) Protocol Background: Molar incisor hypomineralisation (MIH) is a common disorder of tooth development, which has recently been found to be associated with a higher prevalence of hypodontia. The aim of this international multicentre study is to determine the association between MIH and other developmental anomalies in different populations. Methods: Investigators were trained and calibrated for the assessment of MIH and dental anomalies and ethical approvals obtained in each participating country. The study aimed to recruit 584 children with MIH and 584 children without MIH. Patients aged 7–16 years who attend specialist clinics will be invited to participate. Children will undergo a clinical examination to determine the presence and severity of MIH, using an established index. The presence of any other anomalies, affecting tooth number, morphology, or position, will be documented. Panoramic radiographs will be assessed for dental anomalies and the presence of third permanent molars. Statistical analysis, using a chi squared test and regression analysis, will be performed to determine any differences in dental anomaly prevalence between the MIH and non-MIH group and to determine any association between dental anomalies and patient characteristics. Conclusion: This large-scale study has the potential to improve understanding about MIH with benefits for patient management. MDPI 2023-04-28 /pmc/articles/PMC10217515/ /pubmed/37232768 http://dx.doi.org/10.3390/dj11050117 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Protocol
Rodd, Helen D.
Nazzal, Hani
Bonifacio, Clarissa Calil
Ruth, Choe Wei
Crombie, Felicity
El Shahawy, Osama
Folayan, Morenike Oluwatoyin
Gambetta-Tessini, Karla
Goyal, Ashima
Hasmun, Noren
Issa, Ahmad I.
Jundi, Suhad
Manton, David J.
Narasimhan, Srinivasan
Omar, Samah
Parekh, Susan
Popoola, Bamidele O
Silva, Mihiri
Taylor, Greig
Naomi, Yang Qiyue
An International Investigation of Molar Incisor Hypomineralisation (iMIH) and Its Association with Dental Anomalies: Development of a Protocol
title An International Investigation of Molar Incisor Hypomineralisation (iMIH) and Its Association with Dental Anomalies: Development of a Protocol
title_full An International Investigation of Molar Incisor Hypomineralisation (iMIH) and Its Association with Dental Anomalies: Development of a Protocol
title_fullStr An International Investigation of Molar Incisor Hypomineralisation (iMIH) and Its Association with Dental Anomalies: Development of a Protocol
title_full_unstemmed An International Investigation of Molar Incisor Hypomineralisation (iMIH) and Its Association with Dental Anomalies: Development of a Protocol
title_short An International Investigation of Molar Incisor Hypomineralisation (iMIH) and Its Association with Dental Anomalies: Development of a Protocol
title_sort international investigation of molar incisor hypomineralisation (imih) and its association with dental anomalies: development of a protocol
topic Protocol
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10217515/
https://www.ncbi.nlm.nih.gov/pubmed/37232768
http://dx.doi.org/10.3390/dj11050117
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