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Dosimetric Predictors of Toxicity after Prostate Stereotactic Body Radiotherapy: A Single-Institutional Experience of 145 Patients

The indications for stereotactic body radiotherapy (SBRT) for prostate cancer have increased. However, the relationships between adverse events and risk factors remain unclear. This study aimed to clarify associations between adverse events and dose index for prostate SBRT. Participants comprised 14...

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Autores principales: Fujii, Kyohei, Nakano, Masahiro, Kawakami, Shogo, Tanaka, Yuichi, Kainuma, Takuro, Tsumura, Hideyasu, Tabata, Ken-ichi, Satoh, Takefumi, Iwamura, Masatsugu, Ishiyama, Hiromichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10217554/
https://www.ncbi.nlm.nih.gov/pubmed/37232841
http://dx.doi.org/10.3390/curroncol30050383
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author Fujii, Kyohei
Nakano, Masahiro
Kawakami, Shogo
Tanaka, Yuichi
Kainuma, Takuro
Tsumura, Hideyasu
Tabata, Ken-ichi
Satoh, Takefumi
Iwamura, Masatsugu
Ishiyama, Hiromichi
author_facet Fujii, Kyohei
Nakano, Masahiro
Kawakami, Shogo
Tanaka, Yuichi
Kainuma, Takuro
Tsumura, Hideyasu
Tabata, Ken-ichi
Satoh, Takefumi
Iwamura, Masatsugu
Ishiyama, Hiromichi
author_sort Fujii, Kyohei
collection PubMed
description The indications for stereotactic body radiotherapy (SBRT) for prostate cancer have increased. However, the relationships between adverse events and risk factors remain unclear. This study aimed to clarify associations between adverse events and dose index for prostate SBRT. Participants comprised 145 patients irradiated with 32–36 Gy in 4 fractions. Radiotherapy-related risk factors such as dose-volume histogram parameters and patient-related risk factors such as T stage and Gleason score were evaluated in a competing risk analysis. Median follow-up duration was 42.9 months. A total of 9.7% had acute Grade ≥ 2 GU toxicities and 4.8% had acute Grade ≥ 2 GI toxicities. A total of 11.1% had late Grade ≥ 2 GU toxicities and 7.6% had late Grade ≥ 2 GI toxicities. Two (1.4%) patients suffered from late Grade 3 GU toxicities. Similarly, two (1.4%) patients suffered from late Grade 3 GI toxicities. Acute GU and GI events correlated with prostate volume and dose to the hottest 10 cc volume (D10cc)/volumes receiving a minimum of 30 Gy (V30 Gy) of rectum, respectively. Late GI toxicity, frequency, and rectal hemorrhage correlated with rectal D0.1 cc/D1 cc, maximum dose to the bladder, and rectal D0.1 cc, respectively. Toxicities after prostate SBRT using 32–36 Gy/4 fractions were acceptable. Our analysis showed that acute toxicities correlated with volume receiving a medium dose level, and late toxicities correlated with highest point dose of organs at risk.
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spelling pubmed-102175542023-05-27 Dosimetric Predictors of Toxicity after Prostate Stereotactic Body Radiotherapy: A Single-Institutional Experience of 145 Patients Fujii, Kyohei Nakano, Masahiro Kawakami, Shogo Tanaka, Yuichi Kainuma, Takuro Tsumura, Hideyasu Tabata, Ken-ichi Satoh, Takefumi Iwamura, Masatsugu Ishiyama, Hiromichi Curr Oncol Article The indications for stereotactic body radiotherapy (SBRT) for prostate cancer have increased. However, the relationships between adverse events and risk factors remain unclear. This study aimed to clarify associations between adverse events and dose index for prostate SBRT. Participants comprised 145 patients irradiated with 32–36 Gy in 4 fractions. Radiotherapy-related risk factors such as dose-volume histogram parameters and patient-related risk factors such as T stage and Gleason score were evaluated in a competing risk analysis. Median follow-up duration was 42.9 months. A total of 9.7% had acute Grade ≥ 2 GU toxicities and 4.8% had acute Grade ≥ 2 GI toxicities. A total of 11.1% had late Grade ≥ 2 GU toxicities and 7.6% had late Grade ≥ 2 GI toxicities. Two (1.4%) patients suffered from late Grade 3 GU toxicities. Similarly, two (1.4%) patients suffered from late Grade 3 GI toxicities. Acute GU and GI events correlated with prostate volume and dose to the hottest 10 cc volume (D10cc)/volumes receiving a minimum of 30 Gy (V30 Gy) of rectum, respectively. Late GI toxicity, frequency, and rectal hemorrhage correlated with rectal D0.1 cc/D1 cc, maximum dose to the bladder, and rectal D0.1 cc, respectively. Toxicities after prostate SBRT using 32–36 Gy/4 fractions were acceptable. Our analysis showed that acute toxicities correlated with volume receiving a medium dose level, and late toxicities correlated with highest point dose of organs at risk. MDPI 2023-05-16 /pmc/articles/PMC10217554/ /pubmed/37232841 http://dx.doi.org/10.3390/curroncol30050383 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Fujii, Kyohei
Nakano, Masahiro
Kawakami, Shogo
Tanaka, Yuichi
Kainuma, Takuro
Tsumura, Hideyasu
Tabata, Ken-ichi
Satoh, Takefumi
Iwamura, Masatsugu
Ishiyama, Hiromichi
Dosimetric Predictors of Toxicity after Prostate Stereotactic Body Radiotherapy: A Single-Institutional Experience of 145 Patients
title Dosimetric Predictors of Toxicity after Prostate Stereotactic Body Radiotherapy: A Single-Institutional Experience of 145 Patients
title_full Dosimetric Predictors of Toxicity after Prostate Stereotactic Body Radiotherapy: A Single-Institutional Experience of 145 Patients
title_fullStr Dosimetric Predictors of Toxicity after Prostate Stereotactic Body Radiotherapy: A Single-Institutional Experience of 145 Patients
title_full_unstemmed Dosimetric Predictors of Toxicity after Prostate Stereotactic Body Radiotherapy: A Single-Institutional Experience of 145 Patients
title_short Dosimetric Predictors of Toxicity after Prostate Stereotactic Body Radiotherapy: A Single-Institutional Experience of 145 Patients
title_sort dosimetric predictors of toxicity after prostate stereotactic body radiotherapy: a single-institutional experience of 145 patients
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10217554/
https://www.ncbi.nlm.nih.gov/pubmed/37232841
http://dx.doi.org/10.3390/curroncol30050383
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