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Injectable Thermoresponsive Hydrogels for Cancer Therapy: Challenges and Prospects

The enervating side effects of chemotherapeutic drugs have necessitated the use of targeted drug delivery in cancer therapy. To that end, thermoresponsive hydrogels have been employed to improve the accumulation and maintenance of drug release at the tumour site. Despite their efficiency, very few t...

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Detalles Bibliográficos
Autores principales: Tanga, Sandrine, Aucamp, Marique, Ramburrun, Poornima
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10217649/
https://www.ncbi.nlm.nih.gov/pubmed/37233009
http://dx.doi.org/10.3390/gels9050418
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author Tanga, Sandrine
Aucamp, Marique
Ramburrun, Poornima
author_facet Tanga, Sandrine
Aucamp, Marique
Ramburrun, Poornima
author_sort Tanga, Sandrine
collection PubMed
description The enervating side effects of chemotherapeutic drugs have necessitated the use of targeted drug delivery in cancer therapy. To that end, thermoresponsive hydrogels have been employed to improve the accumulation and maintenance of drug release at the tumour site. Despite their efficiency, very few thermoresponsive hydrogel-based drugs have undergone clinical trials, and even fewer have received FDA approval for cancer treatment. This review discusses the challenges of designing thermoresponsive hydrogels for cancer treatment and offers suggestions for these challenges as available in the literature. Furthermore, the argument for drug accumulation is challenged by the revelation of structural and functional barriers in tumours that may not support targeted drug release from hydrogels. Other highlights involve the demanding preparation process of thermoresponsive hydrogels, which often involves poor drug loading and difficulties in controlling the lower critical solution temperature and gelation kinetics. Additionally, the shortcomings in the administration process of thermosensitive hydrogels are examined, and special insight into the injectable thermosensitive hydrogels that reached clinical trials for cancer treatment is provided.
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spelling pubmed-102176492023-05-27 Injectable Thermoresponsive Hydrogels for Cancer Therapy: Challenges and Prospects Tanga, Sandrine Aucamp, Marique Ramburrun, Poornima Gels Review The enervating side effects of chemotherapeutic drugs have necessitated the use of targeted drug delivery in cancer therapy. To that end, thermoresponsive hydrogels have been employed to improve the accumulation and maintenance of drug release at the tumour site. Despite their efficiency, very few thermoresponsive hydrogel-based drugs have undergone clinical trials, and even fewer have received FDA approval for cancer treatment. This review discusses the challenges of designing thermoresponsive hydrogels for cancer treatment and offers suggestions for these challenges as available in the literature. Furthermore, the argument for drug accumulation is challenged by the revelation of structural and functional barriers in tumours that may not support targeted drug release from hydrogels. Other highlights involve the demanding preparation process of thermoresponsive hydrogels, which often involves poor drug loading and difficulties in controlling the lower critical solution temperature and gelation kinetics. Additionally, the shortcomings in the administration process of thermosensitive hydrogels are examined, and special insight into the injectable thermosensitive hydrogels that reached clinical trials for cancer treatment is provided. MDPI 2023-05-16 /pmc/articles/PMC10217649/ /pubmed/37233009 http://dx.doi.org/10.3390/gels9050418 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Tanga, Sandrine
Aucamp, Marique
Ramburrun, Poornima
Injectable Thermoresponsive Hydrogels for Cancer Therapy: Challenges and Prospects
title Injectable Thermoresponsive Hydrogels for Cancer Therapy: Challenges and Prospects
title_full Injectable Thermoresponsive Hydrogels for Cancer Therapy: Challenges and Prospects
title_fullStr Injectable Thermoresponsive Hydrogels for Cancer Therapy: Challenges and Prospects
title_full_unstemmed Injectable Thermoresponsive Hydrogels for Cancer Therapy: Challenges and Prospects
title_short Injectable Thermoresponsive Hydrogels for Cancer Therapy: Challenges and Prospects
title_sort injectable thermoresponsive hydrogels for cancer therapy: challenges and prospects
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10217649/
https://www.ncbi.nlm.nih.gov/pubmed/37233009
http://dx.doi.org/10.3390/gels9050418
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