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Vascular Normalization Caused by Short-Term Lenvatinib Could Enhance Transarterial Chemoembolization in Hepatocellular Carcinoma

We describe the clinical effects of short-term lenvatinib administration prior to conventional transarterial chemoembolization (cTACE) on tumor vasculature. Two patients with unresectable hepatocellular carcinoma underwent high-resolution digital subtraction angiography (DSA) and perfusion four-dime...

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Autores principales: Tachiiri, Tetsuya, Nishiofuku, Hideyuki, Maeda, Shinsaku, Sato, Takeshi, Toyoda, Shohei, Matsumoto, Takeshi, Chanoki, Yuto, Minamiguchi, Kiyoyuki, Taiji, Ryosuke, Kunichika, Hideki, Yamauchi, Satoshi, Ito, Takahiro, Marugami, Nagaaki, Tanaka, Toshihiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10217704/
https://www.ncbi.nlm.nih.gov/pubmed/37232818
http://dx.doi.org/10.3390/curroncol30050360
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author Tachiiri, Tetsuya
Nishiofuku, Hideyuki
Maeda, Shinsaku
Sato, Takeshi
Toyoda, Shohei
Matsumoto, Takeshi
Chanoki, Yuto
Minamiguchi, Kiyoyuki
Taiji, Ryosuke
Kunichika, Hideki
Yamauchi, Satoshi
Ito, Takahiro
Marugami, Nagaaki
Tanaka, Toshihiro
author_facet Tachiiri, Tetsuya
Nishiofuku, Hideyuki
Maeda, Shinsaku
Sato, Takeshi
Toyoda, Shohei
Matsumoto, Takeshi
Chanoki, Yuto
Minamiguchi, Kiyoyuki
Taiji, Ryosuke
Kunichika, Hideki
Yamauchi, Satoshi
Ito, Takahiro
Marugami, Nagaaki
Tanaka, Toshihiro
author_sort Tachiiri, Tetsuya
collection PubMed
description We describe the clinical effects of short-term lenvatinib administration prior to conventional transarterial chemoembolization (cTACE) on tumor vasculature. Two patients with unresectable hepatocellular carcinoma underwent high-resolution digital subtraction angiography (DSA) and perfusion four-dimensional computed tomography during hepatic arteriography (4D-CTHA) before and after administration of lenvatinib treatment. The doses and periods of lenvatinib administration were, respectively, 12 mg/day for 7 days and 8 mg/day for 4 days. In both cases, high-resolution DSA revealed a decrease in dilatation and tortuosity of the tumor vessels. Furthermore, the tumor staining became more refined, and newly formed tiny tumor vessels were observed. Perfusion 4D-CTHA revealed a decrease in arterial blood flow to the tumor by 28.6% (from 487.9 to 139.5 mL/min/100 mg) and 42.5% (from 288.2 to 122.6 mL/min/100 mg) in the two cases, respectively. The cTACE procedure resulted in good lipiodol accumulation and complete response. Patients have remained recurrence-free for 12 and 11 months after the cTACE procedure, respectively. The administration of short-term lenvatinib in these two cases resulted in the normalization of tumor vessels, which likely led to improved lipiodol accumulation and a favorable antitumor effect.
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spelling pubmed-102177042023-05-27 Vascular Normalization Caused by Short-Term Lenvatinib Could Enhance Transarterial Chemoembolization in Hepatocellular Carcinoma Tachiiri, Tetsuya Nishiofuku, Hideyuki Maeda, Shinsaku Sato, Takeshi Toyoda, Shohei Matsumoto, Takeshi Chanoki, Yuto Minamiguchi, Kiyoyuki Taiji, Ryosuke Kunichika, Hideki Yamauchi, Satoshi Ito, Takahiro Marugami, Nagaaki Tanaka, Toshihiro Curr Oncol Case Report We describe the clinical effects of short-term lenvatinib administration prior to conventional transarterial chemoembolization (cTACE) on tumor vasculature. Two patients with unresectable hepatocellular carcinoma underwent high-resolution digital subtraction angiography (DSA) and perfusion four-dimensional computed tomography during hepatic arteriography (4D-CTHA) before and after administration of lenvatinib treatment. The doses and periods of lenvatinib administration were, respectively, 12 mg/day for 7 days and 8 mg/day for 4 days. In both cases, high-resolution DSA revealed a decrease in dilatation and tortuosity of the tumor vessels. Furthermore, the tumor staining became more refined, and newly formed tiny tumor vessels were observed. Perfusion 4D-CTHA revealed a decrease in arterial blood flow to the tumor by 28.6% (from 487.9 to 139.5 mL/min/100 mg) and 42.5% (from 288.2 to 122.6 mL/min/100 mg) in the two cases, respectively. The cTACE procedure resulted in good lipiodol accumulation and complete response. Patients have remained recurrence-free for 12 and 11 months after the cTACE procedure, respectively. The administration of short-term lenvatinib in these two cases resulted in the normalization of tumor vessels, which likely led to improved lipiodol accumulation and a favorable antitumor effect. MDPI 2023-05-05 /pmc/articles/PMC10217704/ /pubmed/37232818 http://dx.doi.org/10.3390/curroncol30050360 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Tachiiri, Tetsuya
Nishiofuku, Hideyuki
Maeda, Shinsaku
Sato, Takeshi
Toyoda, Shohei
Matsumoto, Takeshi
Chanoki, Yuto
Minamiguchi, Kiyoyuki
Taiji, Ryosuke
Kunichika, Hideki
Yamauchi, Satoshi
Ito, Takahiro
Marugami, Nagaaki
Tanaka, Toshihiro
Vascular Normalization Caused by Short-Term Lenvatinib Could Enhance Transarterial Chemoembolization in Hepatocellular Carcinoma
title Vascular Normalization Caused by Short-Term Lenvatinib Could Enhance Transarterial Chemoembolization in Hepatocellular Carcinoma
title_full Vascular Normalization Caused by Short-Term Lenvatinib Could Enhance Transarterial Chemoembolization in Hepatocellular Carcinoma
title_fullStr Vascular Normalization Caused by Short-Term Lenvatinib Could Enhance Transarterial Chemoembolization in Hepatocellular Carcinoma
title_full_unstemmed Vascular Normalization Caused by Short-Term Lenvatinib Could Enhance Transarterial Chemoembolization in Hepatocellular Carcinoma
title_short Vascular Normalization Caused by Short-Term Lenvatinib Could Enhance Transarterial Chemoembolization in Hepatocellular Carcinoma
title_sort vascular normalization caused by short-term lenvatinib could enhance transarterial chemoembolization in hepatocellular carcinoma
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10217704/
https://www.ncbi.nlm.nih.gov/pubmed/37232818
http://dx.doi.org/10.3390/curroncol30050360
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