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Antimicrobial Preservatives for Protein and Peptide Formulations: An Overview
Biological drugs intended for multi-dose application require the presence of antimicrobial preservatives to avoid microbial growth. As the presence of certain preservatives has been reported to increase protein and peptide particle formation, it is essential to choose a preservative compatible with...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10217790/ https://www.ncbi.nlm.nih.gov/pubmed/36839885 http://dx.doi.org/10.3390/pharmaceutics15020563 |
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author | Stroppel, Luisa Schultz-Fademrecht, Torsten Cebulla, Martin Blech, Michaela Marhöfer, Richard J. Selzer, Paul M. Garidel, Patrick |
author_facet | Stroppel, Luisa Schultz-Fademrecht, Torsten Cebulla, Martin Blech, Michaela Marhöfer, Richard J. Selzer, Paul M. Garidel, Patrick |
author_sort | Stroppel, Luisa |
collection | PubMed |
description | Biological drugs intended for multi-dose application require the presence of antimicrobial preservatives to avoid microbial growth. As the presence of certain preservatives has been reported to increase protein and peptide particle formation, it is essential to choose a preservative compatible with the active pharmaceutical ingredient in addition to its preservation function. Thus, this review describes the current status of the use of antimicrobial preservatives in biologic formulations considering (i) appropriate preservatives for protein and peptide formulations, (ii) their physico-chemical properties, (iii) their in-/compatibilities with other excipients or packaging material, and (iv) their interactions with the biological compound. Further, (v) we present an overview of licensed protein and peptide formulations. |
format | Online Article Text |
id | pubmed-10217790 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-102177902023-05-27 Antimicrobial Preservatives for Protein and Peptide Formulations: An Overview Stroppel, Luisa Schultz-Fademrecht, Torsten Cebulla, Martin Blech, Michaela Marhöfer, Richard J. Selzer, Paul M. Garidel, Patrick Pharmaceutics Review Biological drugs intended for multi-dose application require the presence of antimicrobial preservatives to avoid microbial growth. As the presence of certain preservatives has been reported to increase protein and peptide particle formation, it is essential to choose a preservative compatible with the active pharmaceutical ingredient in addition to its preservation function. Thus, this review describes the current status of the use of antimicrobial preservatives in biologic formulations considering (i) appropriate preservatives for protein and peptide formulations, (ii) their physico-chemical properties, (iii) their in-/compatibilities with other excipients or packaging material, and (iv) their interactions with the biological compound. Further, (v) we present an overview of licensed protein and peptide formulations. MDPI 2023-02-07 /pmc/articles/PMC10217790/ /pubmed/36839885 http://dx.doi.org/10.3390/pharmaceutics15020563 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Stroppel, Luisa Schultz-Fademrecht, Torsten Cebulla, Martin Blech, Michaela Marhöfer, Richard J. Selzer, Paul M. Garidel, Patrick Antimicrobial Preservatives for Protein and Peptide Formulations: An Overview |
title | Antimicrobial Preservatives for Protein and Peptide Formulations: An Overview |
title_full | Antimicrobial Preservatives for Protein and Peptide Formulations: An Overview |
title_fullStr | Antimicrobial Preservatives for Protein and Peptide Formulations: An Overview |
title_full_unstemmed | Antimicrobial Preservatives for Protein and Peptide Formulations: An Overview |
title_short | Antimicrobial Preservatives for Protein and Peptide Formulations: An Overview |
title_sort | antimicrobial preservatives for protein and peptide formulations: an overview |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10217790/ https://www.ncbi.nlm.nih.gov/pubmed/36839885 http://dx.doi.org/10.3390/pharmaceutics15020563 |
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