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Chronic Low Back Pain and Incident Transient Ischemic Attack and Stroke in General Practices in Germany
The aim was to investigate the association between chronic low back pain (CLBP) and incident transient ischemic attack (TIA) and stroke in Germany. The present retrospective cohort study included adults aged ≥18 years who were diagnosed for the first time with CLBP in one of 1198 general practices i...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10217849/ https://www.ncbi.nlm.nih.gov/pubmed/37239785 http://dx.doi.org/10.3390/healthcare11101499 |
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author | Jacob, Louis Smith, Lee Koyanagi, Ai Haro, Josep Maria Shin, Jae Il Tanislav, Christian Schnitzler, Alexis Kostev, Karel |
author_facet | Jacob, Louis Smith, Lee Koyanagi, Ai Haro, Josep Maria Shin, Jae Il Tanislav, Christian Schnitzler, Alexis Kostev, Karel |
author_sort | Jacob, Louis |
collection | PubMed |
description | The aim was to investigate the association between chronic low back pain (CLBP) and incident transient ischemic attack (TIA) and stroke in Germany. The present retrospective cohort study included adults aged ≥18 years who were diagnosed for the first time with CLBP in one of 1198 general practices in Germany in 2005–2019 (index date). Patients without CLBP were matched to those with CLBP (1:1) using a propensity score based on age, sex, the index year, the number of medical consultations per year during the follow-up, and the number of years of follow-up. In patients without CLBP, the index date was a randomly selected visit date. Both groups were followed for up to 10 years. There were 159,440 patients included in the study (mean (SD) age: 52.1 (16.5) years; 51.5% women). Within 10 years of the index date, 6.5% and 5.9% of patients with and without CLBP were diagnosed with TIA or stroke, respectively (log-rank p-value < 0.001). The Cox regression analysis corroborated these results, as there was a significant association between CLBP and incident TIA or stroke (HR = 1.28, 95% CI = 1.22–1.35). CLBP was positively and significantly associated with incident TIA and stroke in Germany. More research is warranted to better understand this relationship. |
format | Online Article Text |
id | pubmed-10217849 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-102178492023-05-27 Chronic Low Back Pain and Incident Transient Ischemic Attack and Stroke in General Practices in Germany Jacob, Louis Smith, Lee Koyanagi, Ai Haro, Josep Maria Shin, Jae Il Tanislav, Christian Schnitzler, Alexis Kostev, Karel Healthcare (Basel) Article The aim was to investigate the association between chronic low back pain (CLBP) and incident transient ischemic attack (TIA) and stroke in Germany. The present retrospective cohort study included adults aged ≥18 years who were diagnosed for the first time with CLBP in one of 1198 general practices in Germany in 2005–2019 (index date). Patients without CLBP were matched to those with CLBP (1:1) using a propensity score based on age, sex, the index year, the number of medical consultations per year during the follow-up, and the number of years of follow-up. In patients without CLBP, the index date was a randomly selected visit date. Both groups were followed for up to 10 years. There were 159,440 patients included in the study (mean (SD) age: 52.1 (16.5) years; 51.5% women). Within 10 years of the index date, 6.5% and 5.9% of patients with and without CLBP were diagnosed with TIA or stroke, respectively (log-rank p-value < 0.001). The Cox regression analysis corroborated these results, as there was a significant association between CLBP and incident TIA or stroke (HR = 1.28, 95% CI = 1.22–1.35). CLBP was positively and significantly associated with incident TIA and stroke in Germany. More research is warranted to better understand this relationship. MDPI 2023-05-21 /pmc/articles/PMC10217849/ /pubmed/37239785 http://dx.doi.org/10.3390/healthcare11101499 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Jacob, Louis Smith, Lee Koyanagi, Ai Haro, Josep Maria Shin, Jae Il Tanislav, Christian Schnitzler, Alexis Kostev, Karel Chronic Low Back Pain and Incident Transient Ischemic Attack and Stroke in General Practices in Germany |
title | Chronic Low Back Pain and Incident Transient Ischemic Attack and Stroke in General Practices in Germany |
title_full | Chronic Low Back Pain and Incident Transient Ischemic Attack and Stroke in General Practices in Germany |
title_fullStr | Chronic Low Back Pain and Incident Transient Ischemic Attack and Stroke in General Practices in Germany |
title_full_unstemmed | Chronic Low Back Pain and Incident Transient Ischemic Attack and Stroke in General Practices in Germany |
title_short | Chronic Low Back Pain and Incident Transient Ischemic Attack and Stroke in General Practices in Germany |
title_sort | chronic low back pain and incident transient ischemic attack and stroke in general practices in germany |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10217849/ https://www.ncbi.nlm.nih.gov/pubmed/37239785 http://dx.doi.org/10.3390/healthcare11101499 |
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