The Triterpenoid Nrf2 Activator, CDDO-Me, Decreases Neutrophil Senescence in a Murine Model of Joint Damage

The synthetic 2-cyano-3,12-dioxo-oleana-1,9(11)-dien-28-oic acid methyl ester (CDDO-Me) is a potent activator of the erythroid 2-p45-derived factor 2, Nrf2, a leucine-zipper regulator of the antioxidant response. Herein, we investigated the effect of CDDO-Me on neutrophil function in a murine model...

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Detalles Bibliográficos
Autores principales: Amirova, Kristiana M., Dimitrova, Petya A., Leseva, Milena N., Koycheva, Ivanka K., Dinkova-Kostova, Albena T., Georgiev, Milen I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10217923/
https://www.ncbi.nlm.nih.gov/pubmed/37240121
http://dx.doi.org/10.3390/ijms24108775

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10217923/
https://www.ncbi.nlm.nih.gov/pubmed/37240121
http://dx.doi.org/10.3390/ijms24108775

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