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The Influence of Early Onset Preeclampsia on Perinatal Red Blood Cell Characteristics of Neonates

Preeclampsia is the leading cause of complicated neonatal adaptation. The present investigation aimed to study the hemorheological factors during the early perinatal period (cord blood, 24 and 72 h after delivery) in newborns of early-onset preeclamptic mothers (n = 13) and healthy neonates (n = 17)...

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Autores principales: Sandor, Barbara, Csiszar, Beata, Galos, Gergely, Funke, Simone, Kevey, Dora Kinga, Meggyes, Matyas, Szereday, Laszlo, Toth, Kalman
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10218013/
https://www.ncbi.nlm.nih.gov/pubmed/37239851
http://dx.doi.org/10.3390/ijms24108496
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author Sandor, Barbara
Csiszar, Beata
Galos, Gergely
Funke, Simone
Kevey, Dora Kinga
Meggyes, Matyas
Szereday, Laszlo
Toth, Kalman
author_facet Sandor, Barbara
Csiszar, Beata
Galos, Gergely
Funke, Simone
Kevey, Dora Kinga
Meggyes, Matyas
Szereday, Laszlo
Toth, Kalman
author_sort Sandor, Barbara
collection PubMed
description Preeclampsia is the leading cause of complicated neonatal adaptation. The present investigation aimed to study the hemorheological factors during the early perinatal period (cord blood, 24 and 72 h after delivery) in newborns of early-onset preeclamptic mothers (n = 13) and healthy neonates (n = 17). Hematocrit, plasma, and whole blood viscosity (WBV), red blood cell (RBC) aggregation, and deformability were investigated. There were no significant differences in hematocrit. WBV was significantly lower in preterm neonates at birth than in the term 24 and 72 h samples. Plasma viscosity was significantly lower in preterm neonates’ cord blood than in healthy controls. RBC aggregation parameters were significantly lower in preterm newborns’ cord blood than in term neonates’ cord blood 24 and 72 h samples. RBC elongation indices were significantly lower in the term group than in preterm neonates 72 h’ sample at the high and middle shear stress range. Changes in the hemorheological parameters, especially RBC aggregation properties, refer to better microcirculation of preterm neonates at birth, which could be an adaptation mechanism to the impaired uteroplacental microcirculation in preeclampsia.
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spelling pubmed-102180132023-05-27 The Influence of Early Onset Preeclampsia on Perinatal Red Blood Cell Characteristics of Neonates Sandor, Barbara Csiszar, Beata Galos, Gergely Funke, Simone Kevey, Dora Kinga Meggyes, Matyas Szereday, Laszlo Toth, Kalman Int J Mol Sci Article Preeclampsia is the leading cause of complicated neonatal adaptation. The present investigation aimed to study the hemorheological factors during the early perinatal period (cord blood, 24 and 72 h after delivery) in newborns of early-onset preeclamptic mothers (n = 13) and healthy neonates (n = 17). Hematocrit, plasma, and whole blood viscosity (WBV), red blood cell (RBC) aggregation, and deformability were investigated. There were no significant differences in hematocrit. WBV was significantly lower in preterm neonates at birth than in the term 24 and 72 h samples. Plasma viscosity was significantly lower in preterm neonates’ cord blood than in healthy controls. RBC aggregation parameters were significantly lower in preterm newborns’ cord blood than in term neonates’ cord blood 24 and 72 h samples. RBC elongation indices were significantly lower in the term group than in preterm neonates 72 h’ sample at the high and middle shear stress range. Changes in the hemorheological parameters, especially RBC aggregation properties, refer to better microcirculation of preterm neonates at birth, which could be an adaptation mechanism to the impaired uteroplacental microcirculation in preeclampsia. MDPI 2023-05-09 /pmc/articles/PMC10218013/ /pubmed/37239851 http://dx.doi.org/10.3390/ijms24108496 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Sandor, Barbara
Csiszar, Beata
Galos, Gergely
Funke, Simone
Kevey, Dora Kinga
Meggyes, Matyas
Szereday, Laszlo
Toth, Kalman
The Influence of Early Onset Preeclampsia on Perinatal Red Blood Cell Characteristics of Neonates
title The Influence of Early Onset Preeclampsia on Perinatal Red Blood Cell Characteristics of Neonates
title_full The Influence of Early Onset Preeclampsia on Perinatal Red Blood Cell Characteristics of Neonates
title_fullStr The Influence of Early Onset Preeclampsia on Perinatal Red Blood Cell Characteristics of Neonates
title_full_unstemmed The Influence of Early Onset Preeclampsia on Perinatal Red Blood Cell Characteristics of Neonates
title_short The Influence of Early Onset Preeclampsia on Perinatal Red Blood Cell Characteristics of Neonates
title_sort influence of early onset preeclampsia on perinatal red blood cell characteristics of neonates
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10218013/
https://www.ncbi.nlm.nih.gov/pubmed/37239851
http://dx.doi.org/10.3390/ijms24108496
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