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The Influence of Early Onset Preeclampsia on Perinatal Red Blood Cell Characteristics of Neonates
Preeclampsia is the leading cause of complicated neonatal adaptation. The present investigation aimed to study the hemorheological factors during the early perinatal period (cord blood, 24 and 72 h after delivery) in newborns of early-onset preeclamptic mothers (n = 13) and healthy neonates (n = 17)...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10218013/ https://www.ncbi.nlm.nih.gov/pubmed/37239851 http://dx.doi.org/10.3390/ijms24108496 |
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author | Sandor, Barbara Csiszar, Beata Galos, Gergely Funke, Simone Kevey, Dora Kinga Meggyes, Matyas Szereday, Laszlo Toth, Kalman |
author_facet | Sandor, Barbara Csiszar, Beata Galos, Gergely Funke, Simone Kevey, Dora Kinga Meggyes, Matyas Szereday, Laszlo Toth, Kalman |
author_sort | Sandor, Barbara |
collection | PubMed |
description | Preeclampsia is the leading cause of complicated neonatal adaptation. The present investigation aimed to study the hemorheological factors during the early perinatal period (cord blood, 24 and 72 h after delivery) in newborns of early-onset preeclamptic mothers (n = 13) and healthy neonates (n = 17). Hematocrit, plasma, and whole blood viscosity (WBV), red blood cell (RBC) aggregation, and deformability were investigated. There were no significant differences in hematocrit. WBV was significantly lower in preterm neonates at birth than in the term 24 and 72 h samples. Plasma viscosity was significantly lower in preterm neonates’ cord blood than in healthy controls. RBC aggregation parameters were significantly lower in preterm newborns’ cord blood than in term neonates’ cord blood 24 and 72 h samples. RBC elongation indices were significantly lower in the term group than in preterm neonates 72 h’ sample at the high and middle shear stress range. Changes in the hemorheological parameters, especially RBC aggregation properties, refer to better microcirculation of preterm neonates at birth, which could be an adaptation mechanism to the impaired uteroplacental microcirculation in preeclampsia. |
format | Online Article Text |
id | pubmed-10218013 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-102180132023-05-27 The Influence of Early Onset Preeclampsia on Perinatal Red Blood Cell Characteristics of Neonates Sandor, Barbara Csiszar, Beata Galos, Gergely Funke, Simone Kevey, Dora Kinga Meggyes, Matyas Szereday, Laszlo Toth, Kalman Int J Mol Sci Article Preeclampsia is the leading cause of complicated neonatal adaptation. The present investigation aimed to study the hemorheological factors during the early perinatal period (cord blood, 24 and 72 h after delivery) in newborns of early-onset preeclamptic mothers (n = 13) and healthy neonates (n = 17). Hematocrit, plasma, and whole blood viscosity (WBV), red blood cell (RBC) aggregation, and deformability were investigated. There were no significant differences in hematocrit. WBV was significantly lower in preterm neonates at birth than in the term 24 and 72 h samples. Plasma viscosity was significantly lower in preterm neonates’ cord blood than in healthy controls. RBC aggregation parameters were significantly lower in preterm newborns’ cord blood than in term neonates’ cord blood 24 and 72 h samples. RBC elongation indices were significantly lower in the term group than in preterm neonates 72 h’ sample at the high and middle shear stress range. Changes in the hemorheological parameters, especially RBC aggregation properties, refer to better microcirculation of preterm neonates at birth, which could be an adaptation mechanism to the impaired uteroplacental microcirculation in preeclampsia. MDPI 2023-05-09 /pmc/articles/PMC10218013/ /pubmed/37239851 http://dx.doi.org/10.3390/ijms24108496 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Sandor, Barbara Csiszar, Beata Galos, Gergely Funke, Simone Kevey, Dora Kinga Meggyes, Matyas Szereday, Laszlo Toth, Kalman The Influence of Early Onset Preeclampsia on Perinatal Red Blood Cell Characteristics of Neonates |
title | The Influence of Early Onset Preeclampsia on Perinatal Red Blood Cell Characteristics of Neonates |
title_full | The Influence of Early Onset Preeclampsia on Perinatal Red Blood Cell Characteristics of Neonates |
title_fullStr | The Influence of Early Onset Preeclampsia on Perinatal Red Blood Cell Characteristics of Neonates |
title_full_unstemmed | The Influence of Early Onset Preeclampsia on Perinatal Red Blood Cell Characteristics of Neonates |
title_short | The Influence of Early Onset Preeclampsia on Perinatal Red Blood Cell Characteristics of Neonates |
title_sort | influence of early onset preeclampsia on perinatal red blood cell characteristics of neonates |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10218013/ https://www.ncbi.nlm.nih.gov/pubmed/37239851 http://dx.doi.org/10.3390/ijms24108496 |
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